Month: November 2022

Jansze, Suzanne M.; Ortiz, Daniel; Fadaei Tirani, Farzaneh; Scopelliti, Rosario; Menin, Laure; Severin, Kay published the artcile< Inflating face-capped Pd6L8 coordination cages>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is preparation inflating face capped palladium iron coordination cage complex; crystal structure face capped palladium iron coordination cage complex.

Tritopic metalloligands were used to form two Pd6L8-type coordination cages. With mol. weights of >15 kDa and Pd···Pd distances of up to 4.2 nm, these complexes are among the largest palladium cages described to date. The metalloligands (L1 and L2) were synthesized and characterized by single crystal structure determination One of the two cage complexed were characterized by single crystal structure determination

Chemical Communications (Cambridge, United Kingdom) published new progress about Cage compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (Crystal structure). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sugai, Tomoya; Okuyama, Yuya; Shin, Jaehyun; Usui, Shunme; Hisada, Shoko; Osanai, Ryosuke; Oishi, Takeshi; Sato, Takaaki; Chida, Noritaka published the artcile< Synthesis of kaitocephalin facilitated by three stereoselective allylic transposition reactions>, COA of Formula: C19H34O2, the main research area is kaitocephalin preparation stereoselective Overman Ichikawa rearrangement.

A stereoselective synthesis of kaitocephalin is described. The central strategy is based on chirality transfer reactions of three secondary alcs. derived from L-arabinose. The Overman rearrangement of an α,β-unsaturated ester and intramol. anti-type SN2′ reaction constructed a β-hydroxy-α,α- disubstituted amino acid moiety. The third chirality transfer reaction is the Ichikawa rearrangement. These stereoselective reactions successfully established the three contiguous stereocenters embedded in kaitocephalin.

Chemistry Letters published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Yoshihiro; Shinoda, Hiroyuki; Nakano, Taku; Kitagawa, Taiji published the artcile< Formation and Decay Behaviors of Laser-Induced Transient Species from Pyrene Derivatives 1. Spectral Discrimination and Decay Mechanisms in Aqueous Solution>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is decay mechanism transient species pyrene derivative spectra.

The UV and visible absorption spectra of laser-induced transient species from the following pyrene derivatives were measured in aqueous or aqueous ethanol solution: Na pyrenesulfonate (NaPS), tetrasodium pyrenetetrasulfonate (Na4PS4), pyrenecarboxylic acid (HPC), and pyrenebutyric acid (HPB). The major transient species contributing to the intense absorption peaks were revealed from the quenching experiments The absorption spectra of triplets, as well as cation radicals, were separable from the other transients by selecting the exptl. conditions (atm., coexisting quencher, and delay time). The cation radicals produced from PS-, PB- and PC- anions showed an absorption maximum at ∼460 nm, close to that of pyrene cation radical. Their decay behaviors in the absence of any addnl. quenchers were dominated by bimol. reaction kinetics with each parent mol., of which the rate constants were very similar. This result is consistent with the previous proposal that these cation radicals exist as zwitterions such as P•+S-. The cation radical from Na4PS4 showed a strong absorption peak at 505 nm and exhibited different decay behaviors, suggesting that this cation radical appears not to be a simple zwitterion. Three specific quenchers, I-, OH-, and SO32-, strongly accelerate the decay rates of these cation radicals. MeSO3- anion, mimicking the headgroup of tentative anionic surfactants, and several inorganic anions such as ClO4- were poor quenchers for the cation radicals even at the highest concentration The authors also discussed the origin of two addnl. peaks at 375 and 395 nm observed in the transient absorption spectra of NaPS and HPB. On the triplet-triplet absorption, the molar absorptivities of Na4PS4 and NaPS could be determined using the ground-state depletion method. These results are discussed in terms of applications to probe the micellar microenvironment.

Journal of Physical Chemistry A published new progress about Anionic surfactants (effect on decay of zwitterion of radical cation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glinsky-Olivier, Nicolas; Yang, Shengwen; Retailleau, Pascal; Gandon, Vincent; Guinchard, Xavier published the artcile< Enantioselective Gold-Catalyzed Pictet-Spengler Reaction>, SDS of cas: 112-63-0, the main research area is tetrahydro carboline enantioselective preparation gold catalyst; tryptamine arylaldehyde Pictet Spengler reaction.

Cationic chiral Au(I) complexes catalyze asym. Pictet-Spengler reactions between tryptamines and arylaldehydes. The resulting tetrahydro-β-carbolines I (R1 = H, 5-Me, 5-OMe; R2 = Allyl, Bn, CH2Mes, etc.; R3 = Ph, 4-Et-C6H4, 2-CN-C6H4, 3ClC6H4, etc.)are obtained with wide functional group tolerance in high yield and with high enantioselectivities (up to 95%). Aldehydes bearing polar or protic functions are well tolerated. The reaction features a hitherto unknown C2-auration of the indole as the key step, supported by d. functional theory calculations

Organic Letters published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peddagopu, Nishant; Sanzaro, Salvatore; Rossi, Patrizia; Paoli, Paola; Malandrino, Graziella published the artcile< A One-Pot Synthesis of ""K(hfa) glyme"" Adducts: Effect of the Polyether Length on the Ion Coordination Sphere>, Synthetic Route of 112-63-0, the main research area is potassium diketonate polyether polymeric complex preparation crystal structure; thermal stability potassium diketonate polyether polymeric complex.

Potassium complexes are starting to gather more and more interest from academia and industry because of their intriguing application possibilities. Novel adducts of potassium hexafluoroacetylacetonato [K(hfa)] with polyethers (monoglyme, diglyme, triglyme, and tetraglyme) were synthesized through a single step reaction and characterized through FTIR spectroscopy as well as 1H and 13C NMR spectroscopy. Single crystal x-ray diffraction studies enabled the identification of fascinating K coordination polymeric networks.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mo, F.; Meletti, S.; Belcastro, V.; Quadri, S.; Napolitano, M.; Bello, L.; Dainese, F.; Scarpelli, M.; Florindo, I.; Mascia, A.; Pauletto, G.; Bruno, F.; Pellerino, A.; Giovannini, G.; Polosa, M.; Sessa, M.; Conti Nibali, M.; Di Gennaro, G.; Gigli, G. L.; Pisanello, A.; Cavallieri, F.; Ruda, R. published the artcile< Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study>, Formula: C19H34O2, the main research area is lacosamide brain tumor epilepsy monotherapy population; Epilepsy; Lacosamide; Primary brain tumor; Seizure freedom; Side effects.

Lacosamide (LCM) is a third-generation anti-seizure medication (ASM) approved for focal onset epilepsy in patients aged ≥ 4.378 Previous studies have reported an efficacy of LCM as add-on treatment in brain tumor-related epilepsy (BTRE). To date, there are no studies in the literature focusing on lacosamide used in monotherapy to treat BTRE. In our retrospective study we investigated efficacy and tolerability of LCM in monotherapy in a multicenter national cohort of primary brain tumor patients. We collected from 12 Italian Centers 132 patients with primary brain tumors who were treated with LCM in monotherapy. For each patient we evaluated seizure freedom at 3 and 6 mo (primary endpoints), side effects and drop-out rate (secondary endpoints). Overall, LCM led to seizure freedom in 64.4% of patients at 3 mo and 55% at 6 mo. Patients who used two or more ASMs before LCM had a worse seizure control than patients in monotherapy with LCM as first choice. In 14 patients, we observed seizure control despite tumor progression on magnetic resonance (MRI). Multivariate anal. showed that gross-total resection at diagnosis was significantly associated with higher seizure freedom rate at 6 mo. Side effects were mainly mild (grade 1-2 according to CTCAE classification) and drop-out rate was low (1.5%). Main side effects were dizziness and somnolence. This is the first study showing a good efficacy and tolerability of LCM when used in monotherapy in BTRE. Further prospective studies are needed to confirm these preliminary data, investigating also quality of life and neurocognitive functions.

Journal of Neuro-Oncology published new progress about Anticonvulsants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Yuan; Lu, Jiliang; Zhao, Yuchen; Liao, Weilin; Xing, Enhui; Hu, Xiangguo; Ouyang, Ying; Luo, Yibin; Shu, Xingtian published the artcile< The research of palmitoyl hyperbranched polyglycerol synergized catalytic cracking reaction of hydrocarbons>, Application In Synthesis of 112-63-0, the main research area is palmitoyl hyperbranched polyglycerol catalysis hydrocarbon cracking olefin.

The polymer material palmitoyl hyperbranched polyglycerol (PHPG) was synthesized and studied as carbenium initiator in catalytic cracking reaction for the 1st time. The introduction of PHPG could significantly promote the conversions and light olefins yields in naphtha and model compounds tests (e.g., conversion and yield of light olefins from octane increased by 10.31 and 4.73 percentage points). Control experiments of thermal cracking and anal. of catalytic cracking products selectivities were supportive for the proposal that PHPG functionalized carbenium mechanism by enhancing the carbenium formation step. A 1st-order power law model was established based on the reaction rate derivation of octane and Et-cyclohexane catalytic cracking. Kinetics study revealed the reduction in activation energy (e.g., for octane by 4.2%), and therefore illustrated the alternative reaction path created by the introduced PHPG.

Fuel published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Yong; Liu, Zhiyan; Hou, Enhua; Ma, Nannan; Fan, Jiangping; Jin, Cheng-Yun; Yang, Ruige published the artcile< Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2- yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach>, SDS of cas: 112-63-0, the main research area is Chamaecyparis nootkatensis mol docking study nootkatone.

(+)-Nootkatone, a non-food bioactive natural bicyclic sesquiterpene ketone, is isolated from Chamaecyparis nootkatensis [D. Don] Spach as a renewable forest resource. In continuation of our effort to develop synthetic natural derived insecticides from non-food bioactive products, a small library of thirty N-(1,3- thiazol-2-yl)carboxamides fused (+)-nootkatone was prepared by mol. hybridization and characterized by 1H/13C NMR, HR-MS, and IR spectroscopy. Their insecticidal activities against Mythimna separata Walker and Plutella xylostella Linnaeus were evaluated. Compounds B6, B7, B9, B19-21 and B24 showed better insecticidal activity against M. separata than the botanical insecticide azadirachtin, and their LC50 values ranged from 0.55-0.68 mg/mL. Particularly, compound B9 exhibited 1.87-fold more pronounced insecticidal activity against M. separata than azadirachtin. The insecticidal activity of B21 against P. xylostella was 1.37-fold of that of azadirachtin. Through acetylcholinesterase (AChE) inhibitory activity and mol. docking studies, AChE may be the insecticidal target of B9 against M. separata. In addition, three pronounced compounds B9, B21 and B24 exhibited low hemolytic and cytotoxic activities on normal mammalian cells. These findings will give insights into the further development of (+)-nootkatone derivatives as potentially synthetic natural derived insecticides for pest management.

Industrial Crops and Products published new progress about Cupressus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghosh, Arun K.; Thompson, Wayne J.; Lee, Hee Yoon; McKee, Sean P.; Munson, Peter M.; Duong, Tien T.; Darke, Paul L.; Zugay, Joan A.; Emini, Emilio A. published the artcile< Cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors>, Application of C6H10O5, the main research area is RO 318959 analog HIV protease inhibitor; cyclic sulfonlane asym synthesis HIV inhibitor; virucide sulfolanyloxycarbonylaminohydroxypropyl isoquinolinamide preparation.

Recently the use of urethanes of 3-tetrahydrofuran as P2-ligands for the S2-substrate binding site of HIV-1 protease was reported. The urethane of (S)-3-hydroxy sulfolane substantially increased the in vitro potency of inhibitors relative to the heterocycle 3-tetrahydrofuran. Furthermore, introduction of a small 2-alkyl group cis to the 3-hydroxyl group of either heterocycle system further enhances enzyme affinity. This is consistent with modeling studies using the x-ray crystal structure of the enzyme-inhibitor complex of THF derived inhibitor I and HIV-1 protease. The cis-2-iso-Pr group thus far offers optimum enhancement of the inhibitory properties of the 3-hydroxysulfolane providing an inhibitor II; for HIV-1, IC50 3 nM; for HIV-219, IC50 17 nM) of comparable in vitro antiviral potency to present clin. candidate (3S,4aS,8aS,2’R,3’S)-N-tert-butyl-2-(2′-hydroxy-4′-phenyl-3′-[[[N-(2-quinolinylcarbonyl)-L-asparaginyl]amino]butyl]-decahydroisoquinoline-3-carboxamide (Ro 31-8959), but of reduced mol. weight due to the exclusion of the P3-quinoline ligand. A stereoselective and general synthetic route to this novel class of ligands in optically pure form was developed.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beccalli, Egle M.; Bernasconi, Alice; Borsini, Elena; Broggini, Gianluigi; Rigamonti, Micol; Zecchi, Gaetano published the artcile< Tunable Pd-Catalyzed Cyclization of Indole-2-carboxylic Acid Allenamides: Carboamination vs Microwave-Assisted Hydroamination>, Application of C19H34O2, the main research area is vinyl imidazoindole preparation; indolecarboxylic acid allenamide preparation carboamination hydroamination palladium catalyst.

A variety of 3-vinyl-substituted imidazo[1,5-a]indole derivatives were synthesized by intramol. Pd-catalyzed cyclization of the title allenamides through either a domino carbopalladation/exo-cyclization process or a novel hydroamination reaction that proceeds smoothly under microwave irradiation Both observed pathways involve a π-allyl-palladium(II) complex arising from insertion of the allene group into a palladium(II) species, the latter being formed in situ by the intervention of an aryl iodide or of the N-H group. In both cases, the role of nucleophile is covered by the indole nitrogen.

Journal of Organic Chemistry published new progress about Allenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (allenamides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics