Month: November 2022

Stalinska, Joanna; Vittori, Cecilia; Ingraham, Charles H. IV; Carson, Sean C.; Plaisance-Bonstaff, Karlie; Lassak, Adam; Faia, Celeste; Colley, Susan B.; Peruzzi, Francesca; Reiss, Krzysztof; Jursic, Branko S. published the artcile< Anti-glioblastoma effects of phenolic variants of benzoylphenoxyacetamide (BPA) with high potential for blood brain barrier penetration>, HPLC of Formula: 112-63-0, the main research area is human glioblastoma benzoylphenoxyacetamide blood brain barrier anticancer.

Glioblastomas are the most aggressive brain tumors for which therapeutic options are limited. Current therapies against glioblastoma include surgical resection, followed by radiotherapy plus concomitant treatment and maintenance with temozolomide (TMZ), however, these standard therapies are often ineffective, and average survival time for glioblastoma patients is between 12 and 18 mo. We have previously reported a strong anti-glioblastoma activity of several metabolic compounds, which were synthesized based compounds, which were synthesized based on the chem. structure of a common lipid-lowering drug, fenofibrate, and share a general mol. skeleton of benzoylphenoxyacetamide (BPA). Extensive computational analyses of phenol and naphthol moieties added to the BPA skeleton were performed in this study with the objective of selecting new BPA variants for subsequent compound preparation and anti-glioblastoma testing. Initially, 81 structural variations were considered and their phys. properties such as solubility (logS), blood-brain partitioning (logBB), and probability of entering the CNS calculated by the Central Nervous System-Multiparameter Optimization (MPO-CNS) algorithm were evaluated. From this initial list, 18 compounds were further evaluated for anti-glioblastoma activity in vitro. Nine compounds demonstrated desirable glioblastoma cell toxicity in cell culture, and two of them, HR51, and HR59 demonstrated significantly improved capability of crossing the model blood-brain-barrier (BBB) composed of endothelial cells, astrocytes and pericytes.

Scientific Reports published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Yu-Ye; Lu, Yun-Yang; Sun, Guang-Qiang; Fang, Fei; Ji, Yu-Qiang; Tang, Hai-Feng; Qiu, Peng-Cheng; Cheng, Guang published the artcile< CN-3 increases TMZ sensitivity and induces ROS-dependent apoptosis and autophagy in TMZ-resistance glioblastoma>, HPLC of Formula: 112-63-0, the main research area is temozolomide CN3 anticancer ROS apoptosis autophagy glioblastoma; ROS; TMZ; asterosaponin; glioblastoma; resistance; starfish Culcita novaeguineae.

Many glioma patients develop resistance to temozolomide (TMZ) treatment, resulting in reduced efficacy and survival rates. TMZ-resistant cell lines SHG44R and U87R, which highly express O6-methylguanine DNA methyltransferase (MGMT) and P-gp, were established. CN-3, a new asterosaponin, showed cytotoxic effects on TMZ-resistant cells in a dose- and time-dependent manner via reactive oxygen species (ROS)-mediated apoptosis and autophagy. Transmission electron microscopy and monodansylcadaverine (MDC) staining showed turgidity of the mitochondria and autophagosomes in CN-3-treated SHG44R and U87R cells. The autophagy inhibitor 3-methyladenine was used to confirm the important role of autophagy in CN-3 cytotoxicity in TMZ-resistant cells. The ROS scavenger N-acetyl- L-cysteine (NAC) attenuated the levels of ROS induced by CN-3 and, therefore, rescued the CN-3 cytotoxic effect on the viability of SHG44R and U87R cells by Cell Counting Kit-8 assays and JuLI-Stage videos. MDC staining also confirmed that NAC rescued an autophagosome increase in CN-3-treated SHG44R and U87R cells. Western blotting revealed that CN-3 increased Bax, cleaved-caspase 3, cytochrome C, PARP-1, LC3-II, and Beclin1, and decreased P-AKT, Bcl-2, and p62. Further rescue experiments revealed that CN-3 induced apoptosis and autophagy through ROS-mediated cytochrome C, cleaved-caspase 3, Bcl-2, P-AKT, PARP-1, and LC3-II. In addition, CN-3 promoted SHG44R and U87R cells sensitive to TMZ by reducing the expression of P-gp, MGMT, and nuclear factor kappa B p65, and it had a synergistic cytotoxic effect with TMZ. Moreover, CN-3 disrupted the natural cycle arrest and inhibited the migration of SHG44R and U87R cells by promoting cyclin E1 and D1, and by decreasing P21, P27, N-cadherin, β-catenin, transforming growth factor beta 1, and Smad2.

Journal of Biochemical and Molecular Toxicology published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Zhuoran; Zhao, Yue; Zhang, Shuai; Chen, Xuehui; Sun, Guoming; Zhang, Baoli; Jiang, Bing; Yang, Yili; Yan, Xiyun; Fan, Kelong published the artcile< Re-engineering the inner surface of ferritin nanocage enables dual drug payloads for synergistic tumor therapy>, Quality Control of 112-63-0, the main research area is ferritin nanocage drug synergistic tumor therapy liver cancer; dual drug payloads; hydrophobic drugs loading; inner surface engineering; re-design of ferritin nanocage; synergistic tumor therapy.

With the advantages of tumor-targeting, pH-responsive drug releasing, and biocompatibility, ferritin nanocage emerges as a promising drug carrier. However, its wide applications were significantly hindered by the low loading efficiency of hydrophobic drugs. Herein, we redesigned the inner surface of ferritin drug carrier (ins-FDC) by fusing the C- terminus of human H ferritin (HFn) subunit with optimized hydrophobic peptides. Hydrophobic and hydrophilic drugs were encapsulated into the ins-FDC through the urea-dependent disassembly/reassembly strategy and the natural drug entry channel of the protein nanocage. The morphol. and drug loading/releasing abilities of the drug-loaded nanocarrier were then examined Its tumor targeting character, system toxicity, application in synergistic therapy, and anti-tumor action were further investigated. After optimization, 39 hydrophobic Camptothecin and 150 hydrophilic Epirubicin were encapsulated onto one ins-FDC nanocage. The ins-FDC nanocage exhibited programed drug release pattern and increased the stability and biocompatibility of the loaded drugs. Furthermore, the ins-FDC possesses tumor targeting property due to the intrinsic CD71-binding ability of HFn. The loaded drugs may penetrate the brain blood barrier and accumulate in tumors in vivo more efficiently. As a result, the drugs loaded on ins-FDC showed reduced side effects and significantly enhanced efficacy against glioma, metastatic liver cancer, and chemo-resistant breast tumors. The ins-FDC nanocarrier offers a promising novel means for the delivery of hydrophobic compounds in cancer treatments, especially for the combination therapies that use both hydrophobic and hydrophilic chemotherapeutics.

Theranostics published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Kejiao; Qi, Yuhong; Zhou, Yingju; Sun, Xiaoyu; Zhang, Zhanping published the artcile< Microstructure and properties of poly(ethylene glycol)-segmented polyurethane antifouling coatings after immersion in seawater>, Related Products of 112-63-0, the main research area is polyethylene glycol polyurethane antifouling coating seawater immersion microstructure property; microstructure; poly(ethylene glycol)-segmented polyurethane coating; properties; seawater immersion.

Polyurethane has a microphase separation structure, while polyethylene glycol (PEG) can form a hydrated layer to resist protein adsorption. In this paper, PEG was introduced to polyurethane to improve the antifouling properties of the polyurethane, providing a new method and idea for the preparation of new antifouling polyurethane materials. The mech. properties, hydrophilicity, swelling degree, microphase separation and antifouling performance of the coatings were evaluated. The response characteristics of the polyurethane coatings in a seawater environment were studied, and the performance changes of coatings in seawater were tested. The results showed that the crystallized PEG soft segments increased, promoting microphase separation The stress at 100% and the elasticity modulus of the polyurethane material also markedly increased, in addition to increases in the swelling degree in seawater, the water contact angle decreased. A total of 25% of PEG incorporated into a soft segment can markedly improve the antibacterial properties of the coatings, but adding more PEG has little significant effect. After immersion in seawater, the coatings became softer and more elastic. This is because water mols. formed hydrogen bonding with the amino NH, which resulted in a weakening effect being exerted on the carbonyl C=O hydrogen bonding and ether oxygen group crystallization

Polymers (Basel, Switzerland) published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Joyce H.; Mosher, Eric P.; Lee, Young-Sam; Bumpus, Namandje N.; Berger, James M. published the artcile< Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is topoisomerase chemotherapeutic inhibition TCA cycle metabolite; DNA topology; ICRF-187; TCA cycle; cancer; chemotherapy; dexrazoxane; etoposide; metabolism; topoisomerase.

Topoisomerase II (topo II) is essential for disentangling newly replicated chromosomes. DNA unlinking involves the phys. passage of one duplex through another and depends on the transient formation of double-stranded DNA breaks, a step exploited by frontline chemotherapeutics to kill cancer cells. Although anti-topo II drugs are efficacious, they also elicit cytotoxic side effects in normal cells; insights into how topo II is regulated in different cellular contexts is essential to improve their targeted use. Using chem. fractionation and mass spectrometry, we have discovered that topo II is subject to metabolic control through the TCA cycle. We show that TCA metabolites stimulate topo II activity in vitro and that levels of TCA flux modulate cellular sensitivity to anti-topo II drugs in vivo. Our work reveals an unanticipated connection between the control of DNA topol. and cellular metabolism, a finding with ramifications for the clin. use of anti-topo II therapies.

Cell Chemical Biology published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bouayad-Gervais, Samir; Nielsen, Christian D.-T.; Turksoy, Abdurrahman; Sperger, Theresa; Deckers, Kristina; Schoenebeck, Franziska published the artcile< Access to Cyclic N-Trifluoromethyl Ureas through Photocatalytic Activation of Carbamoyl Azides>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is cyclic trifluoromethyl urea preparation; carbamoyl azide potocatalytic activation.

Mild activation of carbamoyl azides to the corresponding nitrenes using a blue light/[Ir]-catalyzed strategy, which enabled stereospecific access to N-trifluoromethyl imidazolidinones and benzimidazolones was reported. These novel structural motifs proved to be highly robust, allowing their downstream diversification. On the basis of combined computational and exptl. studies, it was proposed that an electron rebound with the excited metal catalyst was undergone, involving a reduction-triggered nitrogen loss, followed by oxidation to the corresponding carbamoyl nitrene and subsequent C-H functionalization.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chopin, Jean; Durand, Roger published the artcile< Action of pyridinium perbromide and trimethylphenylammonium perbromide on several 2'-hydroxychalcones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

The action of the title perbromide compounds in AcOH on I (R = R1 = H) gave I (R = H, R1 = Br), m. 183-5°(BuOH). I (R = H, R1 = Br) was shown to be identical to the product obtained by condensing II (R = H, R1 = Br) with BzH. Treatment of I (R = OMe, R1 = H) under the same conditions with the title perbromide compounds gave almost quant. III (R = Br, R1 = Me), m. 173-5° (benzene), λ (alc.) 294 mμ. Inertness of the bromine indicated nuclear substitution and absence of reaction with FeCl3, cyclization at the phenyl hydroxy group, but neg. reaction with Mg in HCl excluded formation of a heterocyclic 6-membered ring. The action of Br in CCl4 on 2-hydroxy-ω,4,6-trimethoxyacetophenone gave II (R = OMe, R1 = Br), m. 195° (EtOH), λ (alc.) 290 mμ, which, when condensed with BzH, gave I (R = OMe, R1 = Br), m. 149-50° (alc.), λ (alc.) 305 mμ. Thermal cyclization of I (R = OMe, R1 = Br) by the method of Molho, et al. (CA 53, 20043g), gave III (R = Br, R1 = Me), also obtained by action of pyridinium perbromide or of N-bromosuccinimide on III(R = H, R1 = Me). I(R = OMe, R1 = H) was treated with dry HBr gas in AcOH to give starting material, but with I (R = OMe, R1 = Br) there was obtained III (R = Br, R1 = Me), showing that the presence of the nuclear Br was necessary for cyclization. If an AcOH solution of I (R = OMe, R1 = H) is treated in the cold with 40% HBr, there is obtained III (R = R1 = H). Under the same conditions I (R = OMe, R1 = Br) gave III (R = Br, R1 = H). In the presence of 40% HBr in the cold both demethylation and cyclization occur together whether the α-methoxychalcone starting material was brominated or not.

Compt. Rend. published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Suzuki, Shuichi; Nagata, Atsuki; Kuratsu, Masato; Kozaki, Masatoshi; Tanaka, Rika; Shiomi, Daisuke; Sugisaki, Kenji; Toyota, Kazuo; Sato, Kazunobu; Takui, Takeji; Okada, Keiji published the artcile< Trinitroxide-Trioxytriphenylamine: Spin-State Conversion from Triradical Doublet to Diradical Cation Triplet by Oxidative Modulation of a π-Conjugated System>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is trinitroxide trioxytriphenylamine oxidation triradical doublet diradical cation triplet.

Herein, we report an oxidative spin-state conversion from a triradical doublet ground state trinitroxide substituted trioxytriphenylamine (6) (I) to diradical cation triplet ground states (6+) (II). We also determined the crystal structures of 6 and 6+. The spin properties of these compounds were extensively clarified with theor. analyses of zero-field splitting and g tensors.

Angewandte Chemie, International Edition published new progress about Antiferromagnetic exchange. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chatzopoulou, Maria; Emer, Enrico; Lecci, Cristina; Rowley, Jessica A.; Casagrande, Anne-Sophie; Moir, Lee; Squire, Sarah E.; Davies, Stephen G.; Harriman, Shawn; Wynne, Graham M.; Wilson, Francis X.; Davies, Kay E.; Russell, Angela J. published the artcile< Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators>, Computed Properties of 112-63-0, the main research area is benzoxazolephosphinate ester synthesis lipophilicity hepatotoxicity utrophin Duchenne muscular dystrophy.

Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular dystrophy that would be applicable to all patient populations. To improve the suboptimal profile of ezutromid, the first-in-class clin. candidate, a second generation of utrophin modulators bearing a phosphinate ester moiety was developed. This modification significantly improved the physicochem. and ADME properties, but one of the main lead mols. was found to have dose-limiting hepatotoxicity. In this work we describe how less lipophilic analogs retained utrophin modulatory activity in a reporter gene assay, up-regulated utrophin protein in dystrophic mouse muscle cells, but also had improved physicochem. and ADME properties. Notably, ClogP was found to directly correlate with pIC50 in HepG2 cells, hence leading to a potentially safer toxicol. profiles in this series. Compound 21 showed a balanced profile (H2K EC50: 4.17μM, solubility: 477μM, mouse hepatocyte T1/2 > 240 min) and increased utrophin protein 1.6-fold in a Western blot assay.

ACS Medicinal Chemistry Letters published new progress about Cytotoxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boyer, Cyrille; Whittaker, Michael; Liu, Jinna; Davis, Thomas P. published the artcile< Synthesis and post-functionalization of well-defined star polymers via ""double"" click chemistry>, Safety of Perfluorophenyl acrylate, the main research area is functionalization perfluorophenyl acrylate star polymer click chem.

In this communication, the synthesis and the functionalization of well-defined, narrow polydispersity (PDI < 1.2) star polymers via RAFT polymerization is detailed. In this arm first approach, the initial synthesis of a poly(pentafluorophenyl acrylate) arm and subsequent crosslinking using bis-acrylamide to prepare star polymers, was achieved by RAFT polymerization These star polymers were functionalized using a variety of amino functional groups via nucleophilic substitution to yield star polymers with predesigned chem. functionality. Finally, the core of the stars was modified via thiol-ene click chem. reaction using fluorescein-o-acrylate and DyLight 633 Maleimide. PMSE Preprints published new progress about Branched polymers, star-branched Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics