Month: November 2022

Fan, Yuzhen; Scafaro, Andrew P.; Asao, Shinichi; Furbank, Robert T.; Agostino, Antony; Day, David A.; von Caemmerer, Susanne; Danila, Florence R.; Rug, Melanie; Webb, Daryl; Lee, Jiwon; Atkin, Owen K. published the artcile< Dark respiration rates are not determined by differences in mitochondrial capacity, abundance and ultrastructure in C4 leaves>, Synthetic Route of 112-63-0, the main research area is C4 photosynthesis leaf bundle sheath mitochondria light respiration; C4 photosynthetic pathway; C4 plants; bundle sheath; mitochondria; mitochondrial ultrastructure; respiration.

Our understanding of the regulation of respiration in C4 plants, where mitochondria play different roles in the different types of C4 photosynthetic pathway, remains limited. We examined how leaf dark respiration rates (Rdark), in the presence and absence of added malate, vary in monocots representing the three classical biochem. types of C4 photosynthesis (NADP-ME, NAD-ME and PCK) using intact leaves and extracted bundle sheath strands. In particular, we explored to what extent rates of Rdark are associated with mitochondrial number, volume and ultrastructure. Based on examination of a single species per C4 type, we found that the respiratory response of NAD-ME and PCK type bundle sheath strands to added malate was associated with differences in mitochondrial number, volume, and/or ultrastructure, while NADP-ME type bundle sheath strands did not respond to malate addition In general, mitochondrial traits reflected the contributions mitochondria make to photosynthesis in the three C4 types. However, despite the obvious differences in mitochondrial traits, no clear correlation was observed between these traits and Rdark. We suggest that Rdark is primarily driven by cellular maintenance demands and not mitochondrial composition per se, in a manner that is somewhat independent of mitochondrial organic acid cycling in the light.

Plant, Cell & Environment published new progress about Leaf. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seki, Masahiko; Kondo, Kazuhiko published the artcile< A facile synthesis of (S)-4-hydroxypyrrolidin-2-one from (S)-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxypyrrolidinone preparation; pyrrolidinone hydroxy preparation.

The chiral diol (S)-HOCH2CHOHCH2CO2Me obtained from (S)-malate was subjected to regioselective tosylation to give the terminal tosylate in good yield. Subsequent treatment with aqueous NH3 afforded (S)-4-hydroxypyrrolidin-2-one through 3 steps in 32% overall yield.

Synthesis published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

DiMauro, Erin F.; Newcomb, John; Nunes, Joseph J.; Bemis, Jean E.; Boucher, Christina; Chai, Lilly; Chaffee, Stuart C.; Deak, Holly L.; Epstein, Linda F.; Faust, Ted; Gallant, Paul; Gore, Anu; Gu, Yan; Henkle, Brad; Hsieh, Faye; Huang, Xin; Kim, Joseph L.; Lee, Josie H.; Martin, Matthew W.; McGowan, David C.; Metz, Daniela; Mohn, Deanna; Morgenstern, Kurt A.; Oliveira-dos-Santos, Antonio; Patel, Vinod F.; Powers, David; Rose, Paul E.; Schneider, Stephen; Tomlinson, Susan A.; Tudor, Yan-Yan; Turci, Susan M.; Welcher, Andrew A.; Zhao, Huilin; Zhu, Li; Zhu, Xiaotian published the artcile< Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure-Activity Relationships, and Inhibition of in Vivo T Cell Activation>, Product Details of C19H34O2, the main research area is aminopyrimidine amide preparation selective inhibitor lymphocyte specific kinase; T cell activation proliferation inhibitor aminopyrimidine amide; crystal structure lymphocyte specific kinase cocrystal aminopyrimidine amide; mol structure lymphocyte specific kinase cocrystal aminopyrimidine amide.

The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activity is critical for normal T cell development, activation, and signaling. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. With the aid of x-ray structure-based anal., aminopyrimidine amides were designed from aminoquinazolines, which had previously been demonstrated to exhibit potent inhibition of Lck and T cell proliferation. The authors describe the synthesis and structure-activity relations of novel aminopyrimidine amides possessing improved cellular potency and selectivity profiles relative to their aminoquinazoline predecessors. Orally bioavailable compound 2-methyl-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-pyrimidinyl]-5-[[[3-(trifluoromethyl)phenyl]carbonyl]amino]benzamide inhibited the anti-CD3-induced production of interleukin-2 (IL-2) in mice in a dose-dependent manner (ED50 = 9.4 mg/kg). The crystal and mol. structures of cocrystals of Lck kinase with 4-methyl-N3-[2-[4-(4-methylpiperazin-1-yl)phenylamino]pyrimidin-5-yl]-N1-[3-(trifluoromethyl)phenyl]isophthalamide and 2-methyl-N-[4-methyl-3-[[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-pyrimidinyl]amino]carbonyl]phenyl]-3-(trifluoromethyl)benzamide were determined by x-ray crystallog.

Journal of Medicinal Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

DesMarteau, Darryl D.; Petrov, Viacheslav A.; Montanari, Vittorio; Pregnolato, Massimo; Resnati, Giuseppe published the artcile< Mild and Selective Oxygenation of Sulfides to Sulfoxides and Sulfones by Perfluoro-cis-2,3-dialkyloxaziridines>, Related Products of 112-63-0, the main research area is sulfide oxidation perfluorodialkyloxaziridine; oxaziridine perfluorodialkyl oxidation sulfide; sulfone aliphatic aromatic; sulfoxide preparation oxidation.

Sulfides are oxidized to sulfoxides by stoichiometric amounts of perfluoro-cis-2,3-dialkyloxaziridines I (Rf1, Rf2 = n-C4F9, n-C3F7 or n-C6F13, n-C5F11). The reactions proceed at -40° with nearly complete selectivity and very good yields. Sulfoxides are also oxidized easily by I under mild conditions to corresponding sulfones. The oxidation of some bioactive sulfides (promazine, albendazole, biotin, and others) is also reported.

Journal of Organic Chemistry published new progress about Chemoselectivity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kabilan, S.; Girija, R. published the artcile< Kinetics and mechanism of the oxidation of ortho-substituted benzyl alcohols by pyridinium dichromate>, Category: esters-buliding-blocks, the main research area is oxidation benzyl alc ortho substituted pyridinium dichromate kinetics mechanism; LFER oxidation benzyl alc ortho substituted pyridinium dichromate.

The kinetics and mechanism of the oxidation of benzyl alc. and some ortho-substituted benzyl alcs. by pyridinium dichromate (PDC) in the presence of trichloroacetic acid (TCA) in 100% acetonitrile medium have been studied. The product of oxidation has been identified as the corresponding benzaldehyde. The stoichiometry of the reaction is found to be 1.5:1. The reaction is first order each in substrate and oxidant concentrations The mechanism of oxidation varies with the nature of the chromium (VI) species and the solvent used.

Oxidation Communications published new progress about Activation enthalpy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V.; Stemmler, Tobias; Surkus, Annette-Enrica; Junge, Henrik; Junge, Kathrin; Beller, Matthias published the artcile< Hydrogenation using iron oxide-based nanocatalysts for the synthesis of amines>, HPLC of Formula: 112-63-0, the main research area is aryl amine preparation chemoselective; nitro arene iron oxide nanocatalyst hydrogenation; secondary aryl amine preparation; aromatic amine aldehyde iron oxide nanocatalyst reductive amination; iron oxide nitrogen doped graphene layer nanocatalyst preparation.

In this protocol, the preparation of nanoscale iron oxide-based materials and their use in the catalysis of different hydrogenation reactions was described. Pyrolysis of a Fe(OAc)2-phenanthroline complex on carbon at 800 °C under argon atm. results in the formation of nanoscale Fe2O3 particles surrounded by nitrogen-doped graphene layers. By applying these catalysts, the hydrogenation of structurally diverse and functionalized nitroarenes to anilines proceeds with excellent selectivity. Furthermore, it was shown that one-pot reductive amination of carbonyl compounds with nitroarenes was also possible in the presence of these iron oxide catalysts. Herein, the synthesis of more than 40 amines, which are important feedstocks and key intermediates for pharmaceuticals, agrochems. and polymers was also reported. The detailed preparation of the catalysts and the procedures for the hydrogenation processes were presented. The overall time required for the catalyst preparation and for the hydrogenation reactions are 35 h and 20-35 h, resp.

Nature Protocols published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nardeli, Jessica V.; Fugivara, Cecilio S.; Taryba, Maryna; Montemor, M. F.; Benedetti, Assis V. published the artcile< Self-healing ability based on hydrogen bonds in organic coatings for corrosion protection of AA1200>, Formula: C19H34O2, the main research area is aluminum alloy corrosion resistant coating polyurethane microstructure.

Biobased polyurethane coatings derived from vegetable oils, with 2 different compositions, were prepared and applied on the AA1200 aluminum alloy to confer corrosion protection. The influence of the ratio between the polyester (flexible segment) and the prepolymer (rigid segment) was investigated. IR spectroscopy studies evidenced the difference between the areas of the bands (-NH) and optical and SEM evidenced the morphol. features of the coating surface before and after immersion in aggressive medium. The barrier properties and anti-corrosion performance of the coatings were evaluated by electrochem. impedance spectroscopy and the results revealed an increase of impedance over the immersion time. Localized corrosion studies confirmed the self-healing effect in coatings formulated with the highest content of polyester.

Corrosion Science published new progress about Anticorrosive coating materials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Konyukhova, T. M.; Abramenko, P. I.; Kurkina, L. G. published the artcile< Indolomonomethinecyanines, their spectral and polarographic properties>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is indolocyanine monomethine spectra polarog; substituent effect polarog reduction potential.

Twelve indolomonomethinecyanies (I; R = H, Ph; R1 = H, Me; R2 = H, CO2H, CO2Et; R3 = H, Cl, NO2, CO2H) were prepared by condensation of 1-methyl-3-formylindoles with indoles unsubstituted in the 3 position in MeNO2 in the presence of HBr. For R = H, R3 has little effect on the position of the absorption maximum; introduction of R = Ph causes a hypsochromic shift due to steric hindrance. All the I exhibit a low polarog. reduction potential, which is lower for R = Ph than for R = H.

Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D. I. Mendeleeva published new progress about Cyanine dyes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Bit; Sun, Wei; Lee, Hyungjun; Basavarajappa, Halesha; Sulaiman, Rania S.; Sishtla, Kamakshi; Fei, Xiang; Corson, Timothy W.; Seo, Seung-Yong published the artcile< Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids>, Category: esters-buliding-blocks, the main research area is photoaffinity probe antiangiogenic homoisoflavonoid; Antiangiogenic agents; Homoisoflavonoids; Human retinal microvascular endothelial cells; Photoaffinity probes; Wet age-related macular degeneration.

A naturally occurring homoisoflavonoid cremastranone (1) inhibited angiogenesis in vitro and in vivo. The authors developed an analog SH-11037 (2) which is more potent than cremastranone in human retinal microvascular endothelial cells (HRECs) and blocks neovascularization in animal models. Despite their efficacy, the mechanism of these compounds is not yet fully known. In building on a strong foundation of SAR and creating a novel chem. tool for target identification of homoisoflavonoid-binding proteins, various types of photoaffinity probes were designed and synthesized in which benzophenone and biotin were attached to homoisoflavanonoids using PEG linkers on either the C-3′ or C-7 position. Notably, the photoaffinity probes linking on the phenol group of the C-3′ position retain excellent activity of inhibiting retinal endothelial cell proliferation with up to 72 nM of GI50.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiangiogenic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Specklin, Simon; Cossy, Janine published the artcile< Chemoselective Synthesis of β-Ketophosphonates Using Lithiated α-(Trimethylsilyl)methylphosphonate>, Synthetic Route of 71195-85-2, the main research area is lithiated methylsilylmethyl phosphonate preparation coupling pentafluorophenyl ester; ketophosphonate preparation.

A highly chemoselective synthesis of β-ketophosphonates from pentafluorophenyl esters and lithiated Me α-(trimethylsilyl)methylphosphonate was developed. This mild lithiated phosphonate reagent gave functionalized β-ketophosphonates, e.g., PhC(O)CH2P(O)(OMe)2, in the presence of unactivated esters with high yields. This method was compared with the standard lithiated methylphosphonate reagent.

Journal of Organic Chemistry published new progress about Esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (pentafluorophenyl esters). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Synthetic Route of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics