Month: November 2022

Manaila, Elena; Craciun, Gabriela; Ighigeanu, Daniel; Lungu, Ion Bogdan; Dumitru, Marius; Stelescu, Maria Daniela published the artcile< Electron beam irradiation: a method for degradation of composites based on natural rubber and plasticized starch>, Recommanded Product: 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate), the main research area is natural rubber plasticized starch composite electron beam irradiation degradation; phys structural morphol mech property; degradation; electron beam; filler; natural rubber; plasticized starch.

Polymeric composites based on natural rubber (NR) and plasticized starch (PS) obtained by peroxide crosslinking have been subjected to electron beam irradiation in order to investigate their degradation The amount of PS ranged from 10 to 50 phr and the irradiation dose from 150 to 450 kGy. Irradiation was performed in atm. conditions using a linear electron accelerator of 5.5 MeV. Changes in chem., phys., structural, and morphol. properties of composites were correlated with variables, such as PS loading and irradiation dose. Thus, mech. properties, gel fraction, crosslinking degree, water uptake, weight loss in toluene/water were compared with those obtained before irradiation The changes in structure and morphol. were studied by Fourier transform IR spectroscopy and SEM. Both PS loading and irradiation dose were found to be responsible for the degradation installing. Moreover, it has been shown that at the dose of 450 kGy, chain scission is dominant over crosslinking.

Polymers (Basel, Switzerland) published new progress about Absorption (water). 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Recommanded Product: 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crich, David; Fortt, Simon M. published the artcile< Studies on 6,7-unsaturated carbonyl radical cyclizations>, Category: esters-buliding-blocks, the main research area is selenol ester radical cyclization regiochem; ring closure radical unsaturated silenol ester; carbonyl radical unsaturated ring closure; cyclohexanone; cycloheptanone; alkyloxy selenol ester radical cyclization.

6,7-Unsaturated carbonyl radicals, generated by the action of Bu3SnH on the corresponding selenol esters, cyclize to give either cyclohexanones or cycloheptanones, depending on the nature and position of the substituents in the hydrocarbon chain. Thus, cyclization of PhSeCOCH2CHRCH2CHR1CH:CH2 (I, R = H, R1 = OEt) with Bu3SnH gave 27% cycloheptanone II, while I (R = OSiPh2CMe3, R1 = H) gave 57% cyclohexanone III and 17% cycloheptanone II. In all cases, uncyclized aldehydes were isolated as byproducts. Allyloxy selenol esters cyclized similarly to give oxacyclohexanones and oxacyclaheptanones.

Tetrahedron Letters published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Temburnikar, Kartik W.; Ross, Christina R.; Wilson, Gerald M.; Balzarini, Jan; Cawrse, Brian M.; Seley-Radtke, Katherine L. published the artcile< Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is halogenated pyrrolo pyrimidine derivative preparation antitumor cancer; Apoptosis; Cell cycle arrest; Cytostatic; Heterocyclic chemistry; Thieno[3,2-d]pyrimidine.

In vitro evaluation of the halogenated pyrrolo[3,2-d]pyrimidines identified antiproliferative activities in compounds 1 and 2 against four different cancer cell lines. Upon screening of a series of pyrrolo[3,2-d]pyrimidines, the 2,4-Cl compound 1 was found to exhibit antiproliferative activity at low micromolar concentrations Introduction of iodine at C7 resulted in significant enhancement of potency by reducing the IC50 into sub-micromolar levels, thereby suggesting the importance of a halogen at C7. This finding was further supported by an increased antiproliferative effect for 4 as compared to 3. Cell-cycle and apoptosis studies conducted on the two potent compounds 1 and 2 showed differences in their cytotoxic mechanisms in triple neg. breast cancer MDA-MB-231 cells, wherein compound 1 induced cells to accumulate at the G2/M stage with little evidence of apoptotic death. In contrast, compound 2 robustly induced apoptosis with concomitant G2/M cell cycle arrest in this cell model.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Jin; Cai, Xuhong; Liu, Junbo; Liang, Dadong; Chen, Kaiyin; Tang, Shanshan; Xu, Bao published the artcile< Study on the Preparation of Estrone Molecularly Imprinted Polymers and Their Application in a Quartz Crystal Microbalance Sensor via a Computer-Assisted Design>, Synthetic Route of 3290-92-4, the main research area is estrone estriol MIPs itaconic acid quartz crystal microbalance sensor; computational design; estrone; molecularly imprinted polymers; quartz crystal microbalance; selectivity.

Computer simulations are widely used for the selection of conditions for the synthesis of molecularly imprinted polymers and can rapidly reduce the exptl. cycle time and save labor and materials. In this paper, estrone molecularly imprinted polymers (E1-MIPs) are designed at the M062X/6-311+G(d,p) level with itaconic acid (IA) as the functional monomer. The imprinted molar ratio between E1 and IA was optimized, cross-linkers and solvents were screened, and the nature of interactions between E1 and IA was explored. The simulated results showed that pentaerythritol triacrylate was the best cross-linker. Meanwhile, when the imprinted molar ratio between E1 and IA was 1:4, the E1-IA complex had the largest amount of hydrogen bonds, the lowest binding energy, and the strongest stability. Using the simulation results as guidance, the E1-MIPs were prepared to modify the electrons of a quartz crystal microbalance (QCM) sensor. The exptl. studies showed that the E1-MIPs-QCM sensor had the highest adsorption capacity to E1 in comparison with their analogs, and the lowest detection value of the sensor was 16.00 μg/L. The computer simulations and exptl. studies could provide guidance for synthesize novel E1-MIPs materials. It also could provide important references and directions for the application of E1-MIPs.

International Journal of Molecular Sciences published new progress about Adsorption. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Synthetic Route of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pirrung, Michael C.; Liu, Yufa; Deng, Liu; Halstead, Diana K.; Li, Zhitao; May, John F.; Wedel, Michael; Austin, Darrell A.; Webster, Nicholas J. G. published the artcile< Methyl Scanning: Total Synthesis of Demethylasterriquinone B1 and Derivatives for Identification of Sites of Interaction with and Isolation of Its Receptor(s)>, Quality Control of 112-63-0, the main research area is demethylasterriquinone B1 derivative preparation; methyl scanning demethylasterriquinone B1 derivative insulin receptor binding.

The principle of Me scanning is proposed for determination of the sites of interaction between biol. active small mols. and their macromol. target(s). It involves the systematic preparation of a family of methylated derivatives of a compound and their biol. testing. As a functional assay, the method can identify the regions of a mol. that are important (and unimportant) for biol. activity against even unknown targets, and thus provides an excellent complement to structural biol. Me scanning was applied to demethylasterriquinone B1, a small-mol. mimetic of insulin. A new, optimal total synthesis of this natural product was developed that enables the family of Me scan derivatives to be concisely prepared for evaluation in a cellular assay. The results of this experiment were used to design a biotin-demethylasterriquinone conjugate for use as an affinity reagent. This compound was prepared in tens of milligram quantities in a four-step synthesis.

Journal of the American Chemical Society published new progress about Insulin receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lei; Li, Sun; Chauhan, Pankaj; Hack, Daniel; Philipps, Arne R.; Puttreddy, Rakesh; Rissanen, Kari; Raabe, Gerhard; Enders, Dieter published the artcile< Asymmetric, Three-Component, One-Pot Synthesis of Spiropyrazolones and 2,5-Chromenediones from Aldol Condensation/NHC-Catalyzed Annulation Reactions>, HPLC of Formula: 112-63-0, the main research area is pyrazolone enal NHC chiral aldol condensation annulation catalyst; spiropyrazolone stereoselective preparation; diketone cyclic enal NHC chiral aldol condensation annulation catalyst; chromenedione stereoselective preparation; N-heterocyclic carbene; asymmetric synthesis; chromenedione; multicomponent reaction; spiropyrazolone.

A novel one-pot, three-component diastereo- and enantioselective synthesis of spiropyrazolones has been developed involving the aldol condensation of an enal to generate α,β-unsaturated pyrazolones, which react with a second equivalent of enal through an N-heterocyclic carbene (NHC)-catalyzed [3+2] annulation. The desired spirocyclopentane pyrazolones I (R = Ph, 4-MeOC6H4, 2-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 2-furanyl, 3-thienyl, etc.; R1 = t-Bu, Et, 4-MeOC6H4, 2-naphthyl; R2 = Ph, 4-MeOC6H4, 4-BrC6H4, Bn, t-Bu, etc.) are obtained in moderate to good yields and good to excellent stereoselectivities. Alternatively, starting from cyclic 1,3-diketones, 2,5-chromenediones II (R = Ph, 4-MeOC6H4, 4-MeC6H4, 4-ClC6H4, 2-MeOC6H4, etc.; R1= R2= Me, H; R1= H, R2= Ph) are available through [2+4] annulation.

Chemistry – A European Journal published new progress about Aldol condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nevesely, Tomas; Molloy, John J.; McLaughlin, Calum; Bruess, Linda; Daniliuc, Constantin G.; Gilmour, Ryan published the artcile< Leveraging the n→π* Interaction in Alkene Isomerization by Selective Energy Transfer Catalysis>, Product Details of C19H34O2, the main research area is alkene isomerization energy transfer catalysis crystal structure light DFT; alkenes; bioinspired reactions; catalysis; isomerization; stereochemistry.

Examples of geometric alkene isomerization in nature are often limited to the net exergonic direction (ΔG°<0), with the antipodal net endergonic processes (ΔG°>0) comparatively under-represented. Inspired by the expansiveness of the maleate to fumarate (Z→E) isomerization in biochem., we investigated the inverse E→Z variant to validate nO→πC=O* interactions as a driving force for contra-thermodn. isomerization. A general protocol involving selective energy transfer catalysis with inexpensive thioxanthone as a sensitizer (λmax=402 nm) is disclosed. While in the enzymic process nO→πC=O* interactions commonly manifest themselves in the substrate, these same interactions are shown to underpin directionality in the antipodal reaction by shortening the product alkene chromophore. The process was validated with diverse fumarate derivatives (>30 examples, up to Z:E>99:1), including the first examples of tetrasubstituted alkenes, and the involvement of nO→πC=O* interactions was confirmed by X-ray crystallog.

Angewandte Chemie, International Edition published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Multerer, Marie-Theres; Wendler, Martina; Ruther, Joachim published the artcile< The biological significance of lipogenesis in Nasonia vitripennis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nasonia vitripennis lipogenesis biol significance; Nasonia vitripennis; biosynthesis; fatty acids; glucose; parasitic wasp.

Parasitic wasps have long been thought to be unable to synthesize fatty acids de novo, but recent 13C-labeling studies have challenged this view. It remained unclear, however, whether the reported biosynthesis rates are of biol. relevance. Here, we show in Nasonia vitripennis that ageing females with partly depleted lipid reserves produce biol. relevant amounts of fatty acids de novo. Females with varying oviposition history (0-48 h) prior to feeding 20% 13C-labeled glucose solution showed 13C-incorporation rates of (mean ± SEM) 30 ± 2%, 50 ±; 2%, 49 ±; 3% and 21 ± 2% in palmitic, stearic, oleic and linoleic acid, resp. The absolute amounts of fatty acids synthesized de novo across treatments corresponded to 28 ± 3 egg lipid equivalent Females incorporated de novo synthesized fatty acids into their eggs, and glucose-fed females laid more eggs than water-fed control females. The number of eggs laid prior to glucose feeding did not correlate with the degree of lipogenesis, but the amounts of de novo synthesized fatty acids correlated with constitutive (not synthesized de novo) fatty acids. Hence, glucose feeding has a twofold effect on the fatty acid status of N. vitripennis females by decelerating the catabolism of existing fat reserves and partially replenishing ebbing fat reserves by lipogenesis.

Proceedings of the Royal Society B: Biological Sciences published new progress about Bacteroides oleiciplenus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Colombo, Maria I.; Zinczuk, Juan; Mischne, Mirta P.; Ruveda, Edmundo A. published the artcile< Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol>, Application of C7H12O5, the main research area is asym synthesis trisporic acid White intermediate preparation; cassiol intermediate preparation asym synthesis trisporic acid; resolution chiral auxiliary asym synthesis trisporic acid intermediate preparation; Michael addition asym synthesis trisporic acid White intermediate preparation; aldol condensation asym synthesis trisporic acid White intermediate preparation; olefination asym synthesis trisporic acid White intermediate preparation.

An enantioselective synthesis and resolution of the key White intermediate I for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (II) by an olefination reaction of I and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported.

Pure and Applied Chemistry published new progress about Aldol condensation. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Application of C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jo, Hanju; Haberkorn, Niko; Pan, Jia-Ahn; Vakili, Mohammad; Nielsch, Kornelius; Theato, Patrick published the artcile< Fabrication of Chemically Tunable, Hierarchically Branched Polymeric Nanostructures by Multi-branched Anodic Aluminum Oxide Templates>, Electric Literature of 71195-85-2, the main research area is branched polymeric nanostructure multi anodic aluminum oxide template.

In this paper, a template-assisted replication method is demonstrated for the fabrication of hierarchically branched polymeric nanostructures composed of post-modifiable poly(pentafluorophenyl acrylate). Anodic aluminum oxide templates with various shapes of hierarchically branched pores are fabricated by an asym. two-step anodization process. The hierarchical polymeric nanostructures are obtained by infiltration of pentafluorophenyl acrylate with a crosslinker and photoinitiator, followed by polymerization and selective removal of the template. Furthermore, the nanostructures containing reactive pentafluorophenyl ester are modified with spiropyran amine via post-polymerization modification to fabricate UV-responsive nanostructures. This method can be readily extended to other amines and offers a generalized strategy for controlling functionality and wettability of surfaces.

Langmuir published new progress about Anodization. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics