Month: November 2022

Cheng, Jie; Liu, Ying; Yan, Jinxin; Zhao, Lina; Zhou, Yinglin; Shen, Xuyang; Chen, Yunan; Chen, Yining; Meng, Xianbin; Zhang, Xinxiang; Jiang, Peng published the artcile< Fumarate suppresses B-cell activation and function through direct inactivation of LYN>, Computed Properties of 112-63-0, the main research area is B cell activation LYN fumarate TCA cycle.

Activated B cells increase central carbon metabolism to fulfill their bioenergetic demands, yet the mechanistic basis for this, as well as metabolic regulation in B cells, remains largely unknown. Here, we demonstrate that B-cell activation reprograms the tricarboxylic acid cycle and boosts the expression of fumarate hydratase (FH), leading to decreased cellular fumarate abundance. Fumarate accumulation by FH inhibition or dimethyl-fumarate treatment suppresses B-cell activation, proliferation and antibody production Mechanistically, fumarate is a covalent inhibitor of tyrosine kinase LYN, a key component of the BCR signaling pathway. Fumarate can directly succinate LYN at C381 and abrogate LYN activity, resulting in a block to B-cell activation and function in vitro and in vivo. Therefore, our findings uncover a previously unappreciated metabolic regulation of B cells, and reveal LYN is a natural sensor of fumarate, connecting cellular metabolism to B-cell antigen receptor signaling.

Nature Chemical Biology published new progress about Animal gene, lyn Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dienel, Kasper E. G.; van Bochove, Bas; Seppala, Jukka V. published the artcile< Additive Manufacturing of Bioactive Poly(trimethylene carbonate)/β-Tricalcium Phosphate Composites for Bone Regeneration>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is additive manufacturing polytrimethylene carbonate beta tricalcium phosphate composite bone.

Implants of bioresorbable materials combined with osteoconductive calcium phosphate ceramics show promising results to replace and repair damaged bone tissue. Here we present additive manufacturing of patient-specific porous scaffolds of poly(trimethylene carbonate) (PTMC) including high amounts of β-tricalcium phosphate (β-TCP). Tensile testing of composite networks showed that addition of β-tricalcium phosphate reinforces the composites significantly. Three-dimensional structures containing up to 60 weight % β-TCP could be built by stereolithog. By lowering the content to 51 weight %, manufacturing of a large-sized patient-specific prototype was possible at high resolution Closer examination revealed that the created scaffolds contained more β-TCP on the surface of the builds. Stereolithog. therefore provides a manufacturing technique where the bioactive agent is directly available for creating an enhanced microenvironment for cell growth. The biocompatibility and bioresorption of PTMC coupled with the osteocond. of β-TCP are an important candidate to consider in additive manufacturing of bone regeneration implants.

Biomacromolecules published new progress about Biocompatibility. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peters, Katherine B; Affronti, Mary L; Woodring, Sarah; Lipp, Eric; Healy, Patrick; Herndon, James E 2nd; Miller, Elizabeth S; Freeman, Maria W; Randazzo, Dina M; Desjardins, Annick; Friedman, Henry S published the artcile< Effects of low-dose naltrexone on quality of life in high-grade glioma patients: a placebo-controlled, double-blind randomized trial.>, Application In Synthesis of 112-63-0, the main research area is Fatigue; Glioma; High-grade; Low-dose; Naltrexone; Quality of life.

PURPOSE: At diagnosis and throughout the disease course, patients with high-grade glioma (HGG) experience a diminished quality of life (QOL) and increased fatigue. Naltrexone, an orally semisynthetic opiate antagonist, is FDA-approved for the treatment of heroin/alcohol addiction, and low-dose naltrexone (LDN) has been observed to improve QOL and lower fatigue in other neurological illnesses, such as multiple sclerosis. LDN is believed to function as a partial agonist and can lead to shifts in neurochemicals that reduce fatigue. Based on this, we sought to study whether LDN has an impact on QOL and fatigue in patients with HGG. METHODS: In a placebo-controlled, double-blind study, we randomized 110 HGG patients to receive placebo (N = 56) or LDN 4.5 mg orally at night (N = 54). Subjects received LDN or placebo at day 1 of concurrent radiation and temozolomide therapy and continued for 16 weeks. Change from baseline in patient-reported outcomes of QOL (Functional Assessment of Cancer Therapy-Brain) and fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue) was assessed. RESULTS: Demographics were WHO grade IV (85%), male (56%), KPS 90-100 (51%), grossly resected (55%), and mean age of 56 years. QOL and fatigue changes between baseline and post concurrent chemotherapy and radiation therapy were not significantly different between patients receiving LDN or placebo. The adverse event profiles for LDN and placebo were similar and attributed to concomitant use of temozolomide. CONCLUSIONS: LDN has no effect on QOL and fatigue in HGG patients during concurrent chemotherapy and radiation therapy. TRIAL REGISTRATION: United States National Library of Medicine Clinical Trials.gov NCT01303835, Date 2/25/2011.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bogyo, Matthew; Mcmaster, John S.; Gaczynska, Maria; Tortorella, Domenico; Goldberg, Alfred L.; Ploegh, Hidde published the artcile< Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HslV by a new class of inhibitors>, Application In Synthesis of 112-63-0, the main research area is proteasome peptide vinylsulfone threonine active site; HslV peptide vinylsulfone inhibitor Escherichia ATP; Non-programmatic.

The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl sulfone, carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L3VS) covalently inhibits the trypsin-like, chymotrypsin-like and, unlike lactacystin, also the peptidyl-glutamyl peptidase activity in isolated proteasomes, and blocks their function in living cells. Although described as a class of mechanism-based inhibitors for cysteine proteases, the peptide vinyl sulfone Z-L3VS and a 125I-labeled nitrophenol derivative (125I-NIP-L3VS) covalently modify the active site threonine of the catalytic β subunits of the proteasome. Modification of Thermoplasma proteasomes demonstrates the requirement for a hydroxyl amino acid (threonine, serine) as nucleophile at the β subunit’s NH2 terminus. 125I-NIP-L3VS covalently modifies the HslV subunit of the Escherichia coli protease complex HslV/HslU, a reaction that requires ATP, and supports a catalytic mechanism shared with that of the eukaryotic proteasome.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Enzyme functional sites, active. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Warashina, Takuya; Matsuura, Daisuke; Sengoku, Tetsuya; Takahashi, Masaki; Yoda, Hidemi; Kimura, Yoshikazu published the artcile< Regioselective Formylation of Pyrrole-2-Carboxylate: Crystalline Vilsmeier Reagent vs Dichloromethyl Alkyl Ether>, SDS of cas: 7126-50-3, the main research area is regioselective formylation pyrrolecarboxylate; crystalline Vilsmeier reagent dichloromethyl alkyl ether preparation; formyl pyrrolecarboxylate preparation.

New preparations of crystalline Vilsmeier reagent (VR) and dichloromethyl Pr or Bu ether were developed. The methods are environmentally benign and applicable to large-scale synthesis. Formylations of 1H-pyrrole-2-carboxylates were achieved with these reagents, regioselectively affording the 4-formyl and 5-formyl derivatives in nearly quant. yields.

Organic Process Research & Development published new progress about Ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (dichloromethyl alkyl). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, SDS of cas: 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

McKenzie, Alec I.; Mahmassani, Ziad S.; Petrocelli, Jonathan J.; de Hart, Naomi M. M. P.; Fix, Dennis K.; Ferrara, Patrick J.; LaStayo, Paul C.; Marcus, Robin L.; Rondina, Matthew T.; Summers, Scott A.; Johnson, Jordan M.; Trinity, Joel D.; Funai, Katsuhiko; Drummond, Micah J. published the artcile< Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial>, Category: esters-buliding-blocks, the main research area is skeletal muscle mitochondrial H2O2 metformin clin dose healthy adult; Aging; Complex I respiration; Free radicals; Insulin sensitizers; Metabolism; Mitochondria; Muscle stem cells.

Metformin is the most commonly prescribed medication to treat diabetes. Emerging evidence suggests that metformin could have off target effects that might help promote healthy muscle aging, but these effects have not been thoroughly studied in glucose tolerant older individuals. The purpose of this study was to investigate the short-term effects of metformin consumption on skeletal muscle mitochondrial bioenergetics in healthy older adults. We obtained muscle biopsy samples from 16 healthy older adults previously naive to metformin and treated with metformin (METF; 3F, 5M), or placebo (CON; 3F, 5M), for two weeks using a randomized and blinded study design. Samples were analyzed using high-resolution respirometry, immunofluorescence, and immunoblotting to assess muscle mitochondrial bioenergetics, satellite cell (SC) content, and associated protein markers. We found that metformin treatment did not alter maximal mitochondrial respiration rates in muscle compared to CON. In contrast, mitochondrial H2O2 emission and production were elevated in muscle samples from METF vs. CON (METF emission: 2.59 ± 0.72 SE Fold, P = 0.04; METF production: 2.29 ± 0.53 SE Fold, P = 0.02). Furthermore, the change in H2O2 emission was pos. correlated with the change in type 1 myofiber SC content and this was biased in METF participants (Pooled: R2 = 0.5816, P = 0.0006; METF: R2 = 0.674, P = 0.0125). These findings suggest that acute exposure to metformin does not impact mitochondrial respiration in aged, glucose-tolerant muscle, but rather, influences mitochondrial-free radical and SC dynamics.Clin. trial registration. NCT03107884, clinicaltrials.gov.

Experimental Gerontology published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanaka, Hiroyoshi; Ratoi, Monica; Sugimura, Joichi published the artcile< The role of synthetic oils in controlling hydrogen permeation of rolling/sliding contacts>, Application of C19H34O2, the main research area is hydrogen synthetic oil permeation rolling sliding contact.

Bearing steels suffer from degradation of mech. properties when at. hydrogen diffuses into the steel from the contact surface. In rolling contact fatigue tests this can lead to a significant reduction in fatigue life of the specimens as the amount of hydrogen diffused into the steel increases. To mitigate this challenge, synthetic oils of different chem. have been studied so as to identify their efficiency and mechanism of retarding or preventing hydrogen permeation. Thrust bearing type tests were conducted with three synthetic base oils. The effect of base oil chem. on hydrogen generation and permeation in bearing steel was explored by relating the concentration of hydrogen species in specimens with changes in the surface and subsurface of the wear track and the condition of the oil.

RSC Advances published new progress about Air. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Victory, Pedro; Sempere, Julian; Borrell, Jose I.; Crespo, Ana published the artcile< Synthesis of 4-dimethoxymethyl-6-hydroxy-2-methoxynicotinonitrile: a suggested mechanism revision>, Application In Synthesis of 60705-25-1, the main research area is nicotinonitrile dimethoxymethylhydroxymethoxy.

Me 4,4-dimethoxy-3-oxobutyrate condenses with malonodinitrile in methanolic sodium methoxide to form 4-dimethoxymethyl-2-methoxypyridine-3-carbonitrile. A previously proposed interpretation of this reaction is shown to be only one of several which allow the formation of one isomer or another [6-alkoxy-2-hydroxy- or 2-alkoxy-6-hydroxy-3-cyano-pyridines] depending on the pH of the medium.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Knoevenagel reaction. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Application In Synthesis of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Byun, Hun-Soo; Kim, Chang-Ryung; Yoon, Soon-Do published the artcile< Cloud-point measurement of binary and ternary mixtures for the P(MMA-co-PnFPA) in supercritical fluoric solvents>, Related Products of 71195-85-2, the main research area is methyl methacrylate pentafluorophenyl acrylate copolymer supercritical fluorocarbon cloud point.

In this work, the poly(Me methacrylate-co-pentafluorophenyl acrylate) [P(MMA-co-PnFPA)] copolymer by dispersion polymerization in supercritical carbon dioxide was prepared The physicochem. properties for the P(MMA-co-PnFPA) were investigated with varied mole ratios of MMA vs PnFPA (20:1, 25:1 and 30:1), and 1.0 weight%, 2.0 weight% and 4.0 weight% AIBN amounts Exptl. cloud-point data up to 453 K and 220 MPa are measured for binary and ternary mixtures of P(MMA-co-PnFPA) in supercritical CH2F2, CHF3 and CHClF2. Phase behavior of binary systems for the P(MMA-co-PnFPA) [mole ratio = 25:1, AIBN: 1.0 weight% (Mw = 173,000), 2.0 weight% (Mw = 93,600), and 4.0 weight% (Mw = 74,600)] + CH2F2 (or CHF3 and CHClF2) mixtures at temperature range from 333 K to 434 K and pressure up to 153 MPa are measured the upper critical solution temperature (UCST) type behavior with neg. slope for the P(MMA-co-PnFPA) + CH2F2, and lower critical solution temperature (LCST) type curve with pos. slope for the P(MMA-co-PnFPA) + CHF3 and P(MMA-co-PnFPA) + CHClF2 mixtures Cloud-point curves for the P(MMA-co-PnFPA) [mole ratio = 20:1 (Mw = 170,000), 25:1 (Mw = 173,000), and 30:1 (Mw = 228,000); 1.0 weight% AIBN] + supercritical (CH2F2, CHF3 and CHClF2) mixtures show a neg. slope for the P(MMA-co-PnFPA) + CH2F2, and a pos. slope for the P(MMA-co-PnFPA) + CHF3 and P(MMA-co-PnFPA) + CHClF2 mixtures at temperature to 453 K and pressure up to 160 MPa. Also, the impact of MMA (or CHClF2) on phase behavior for the P(MMA-co-PnFPA) (25:1; 1.0 weight% AIBN) + CH2F2 mixtures are measured in changes of the pressure-temperature (p, T) slope from UCST behavior to LCST behavior, and with MMA (or CHClF2) co-solvent concentrations of (0.0-28.9) weight% (or CHClF2: 0.0-97.2 weight%).

Journal of Supercritical Fluids published new progress about Cloud point. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Related Products of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xuewen; Cai, Changqing; Liang, Qichang; Xia, Meng; Lai, Lihua; Wu, Xia; Jiang, Xiaoyun; Cheng, Hao; Song, Yinjing; Zhou, Qiang published the artcile< Integrated transcriptomics and metabolomics analyses of stress-induced murine hair follicle growth inhibition>, Application of C19H34O2, the main research area is hair follicle growth inhibition psychol stress transcriptome metabolome; chronic restraint stress; hair growth inhibition; hexokinase-1; metabolomics; transcriptomics.

Psychol. stress plays an important role in hair loss, but the underlying mechanisms are not well-understood, and the effective therapies available to regrow hair are rare. In this study, we established a chronic restraint stress (CRS)-induced hair growth inhibition mouse model and performed a comprehensive anal. of metabolomics and transcriptomics. Metabolomics data anal. showed that the primary and secondary metabolic pathways, such as carbohydrate metabolism, amino acid metabolism, and lipid metabolism were significantly altered in skin tissue of CRS group. Transcriptomics anal. also showed significant changes of genes expression profiles involved in regulation of metabolic processes including arachidonic acid metabolism, glutathione metabolism, glycolysis gluconeogenesis, nicotinate and nicotinamide metabolism, purine metabolism, retinol metabolism and cholesterol metabolism Furthermore, RNA-Seq analyses also found that numerous genes associated with metabolism were significantly changed, such as Hk-1, in CRS-induced hair growth inhibition. Overall, our study supplied new insights into the hair growth inhibition induced by CRS from the perspective of integrated metabolomics and transcriptomics analyses.

Frontiers in Molecular Biosciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (biosynthesis). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics