Month: November 2022

Zhu, Bo; Yan, Lin; Pan, Yuanhang; Lee, Richmond; Liu, Hongjun; Han, Zhiqiang; Huang, Kuo-Wei; Tan, Choon-Hong; Jiang, Zhiyong published the artcile< Lewis base catalyzed enantioselective allylic hydroxylation of Morita-Baylis-Hillman carbonates with water>, Electric Literature of 112-63-0, the main research area is alc enantioselective synthesis; Morita Baylis Hillman carbonate allylic hydroxylation Lewis base catalyst.

A Lewis base catalyzed allylic hydroxylation of Morita-Baylis-Hillman (MBH) carbonates has been developed. Various chiral MBH alcs. can be synthesized in high yields (up to 99%) and excellent enantioselectivities (up to 94% ee). This is the first report using water as a nucleophile in asym. organocatalysis. The nucleophilic role of water has been verified using 18O-labeling experiments

Journal of Organic Chemistry published new progress about Allylic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yanyan; Yin, Shaojie; Chen, Xiaolan; Shi, Feifei; Wang, Jing; Yang, Haifeng published the artcile< The inhibitory effect of paeoniflorin on reactive oxygen species alleviates the activation of NF-κB and MAPK signalling pathways in macrophages.>, SDS of cas: 112-63-0, the main research area is MAPK; NF-κB; ROS; inflammation; macrophages; paeoniflorin.

Paeoniflorin (PF) has been proven to possess a protective effect in some inflammatory diseases, but the underlying mechanism remains unclear. Macrophages play central roles in inflammatory responses and LPS-stimulated RAW264.7 macrophage is an ideal model for studying the anti-inflammatory effects and mechanisms of drugs. Thus, it was used to explore the anti-inflammatory mechanism of PF in this study. The results showed that PF markedly attenuated the activation of NF-κB, extracellular signal-regulated kinase (ERK1/2) and p38 mitogen activated protein kinase (p38) signalling pathways induced by LPS exposure. In addition, PF pretreatment dose-dependently suppressed the production of cytokines and the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Concomitantly, PF pretreatment dramatically inhibited the accumulation of intracellular reactive oxygen species (ROS) without affecting the phagocytosis of macrophages. Furthermore, it has proved the scavenging effect of PF on ROS was involved in the anti-inflammatory process. This study provides a novel aspect to the understanding of the anti-inflammatory mechanism of PF.

Microbiology (Reading, England) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alekseyev, Roman S.; Amirova, Sabina R.; Terenin, Vladimir I. published the artcile< Synthesis of 5-chloro-7-azaindoles by Fischer reaction>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azaindole preparation; hydrazinopyridine polyphosphoric acid Fischer cyclization.

A simple and effective method on the basis of Fischer reaction in polyphosphoric acid is proposed for the synthesis of previously unknown heterocyclic structures that contain the 5-chloro-1H-pyrrolo[2,3-b]pyridine system. This method can be used for the synthesis of 3-substituted and 2,3-disubstituted 5-chloro-7-azaindoles, e.g., I, with alkyl and aryl substituents.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lokhov, R. E. published the artcile< Kinetics of N-oxidation of compounds of the quinoline series and isomeric benzoquinolines by perbenzoic acid in chloroform and aqueous dioxane>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oxidation quinoline benzoquinoline peroxybenzoic acid.

Rate constants and activation parameters were determined for the title reactions; a bimol. mechanism was indicated. Annelation of pyridine lowered its oxidation rate. The rate constant for oxidation of 4-amino-2,3-benzoquinoline was nearly an order of magnitude higher in CHCl3 than in aqueous dioxane. Correlations with nucleophilicity parameters and half-wave potentials for the reduction of the azine cations were discussed. The electron d. at N had a small effect; π conjugation between the substituent and the reaction center was an important factor.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Nucleophilicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amey, Ronald L.; Martin, J. C. published the artcile< Synthesis and reactions of stable alkoxyaryltrifluoroperiodinanes. A ""tamed"" analog of iodine pentafluoride for use in oxidations of amines, alcohols, and other species>, Synthetic Route of 112-63-0, the main research area is iodinane per alkoxyaryl trifluoro; periodinane alkoxyaryl trifluoro; oxidation periodinane alc amine; iodine pentafluoride analog; benziodoxole preparation reaction.

Stable alkoxyaryltrifluoroperiodinanes I and II were prepared by oxidation of the resp. parent iodo alcs. 5,2-MeIC6H3C(CF3)2OH and 2-IC6H4CMe2OH with excess CF3OF. The stability and low reactivity of I and II are ascribed to the strong stabilizing influence of the 5-membered ring. The reaction of I with Me3SiCl gives the corresponding iodine(III) species, III, and chlorine. I is hydrolyzed with aqueous base to give a species thought to be iodinane oxide (IV). I is a selective reagent for the oxidation of primary and secondary amines or alcs. bearing α hydrogens to the corresponding aldehyde or ketone. In contrast to iodine pentafluoride, I does not further oxidize the product aldehydes to acids. tert-Butylamine is oxidized by I to give 1,1,1′,1′-tetramethylazoethane. PhMgBr reacts with I to give PhF. Possible mechanisms for these selective oxidations are discussed. It is suggested that the stabilizing structural features of I make it a tamed analog of IF5.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamazaki, Shigeo; Nagaya, Shoko; Saito, Katsunori; Tanimura, Takenori published the artcile< Enantiomeric separation of underivatized aliphatic β-amino alcohols by ligand-exchange chromatography using barbital as an additive to the mobile phase>, Reference of 112-63-0, the main research area is enantiomer separation aliphatic amino alc HPLC; ligand exchange chromatog amino alc enantiomer; barbital additive HPLC mobile phase; copper additive HPLC mobile phase; HPLC amino alc enantiomer; liquid chromatog amino alc enantiomer.

Underivatized aliphatic β-amino alcs. with a secondary alc. moiety were separated into enantiomers by HPLC using octadecylsilanized silica coated with N-n-dodecyl-L-hydroxyproline as the stationary phase and an aqueous solution containing copper(II) and barbital as the mobile phase.

Journal of Chromatography A published new progress about Amino alcohols Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schoene, Jens; Gazzi, Thais; Lindemann, Peter; Christmann, Mathias; Volkamer, Andrea; Nazare, Marc published the artcile< Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors>, Computed Properties of 112-63-0, the main research area is nitrogen heterocycle indazole synthesis SGK1 Tie2 SRC kinase; docking; drug design; focused library; kinase inhibition; nitrogen heterocycles; scaffolds.

The broader and systematic application of a novel scaffold is often hampered by the unavailability of a short and reliable synthetic access. We investigated a new strategy for the design and synthesis of an array of N2-substituted aza-2H-indazole derivatives as potential kinase inhibitors. Guided by a rational ligand alignment approach to qualify the so-far underrepresented aza-2H-indazole scaffold, indazoles were connected at the N2 position with a Ph spacer and an arylsulfonamide or amide linkage. Initial profiling against a panel of 30 kinases confirmed the in silico predicted selectivity bias. A synthesized focused library of 52 different aza-2H-indazole derivatives showed good initial selective inhibition against SGK1, Tie2, and SRC kinases, with the best representatives having IC50 values in the range of 500 nM. In a comparative computational study, these data were analyzed and rationalized in light of docking studies.

ChemMedChem published new progress about Drug targets. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schleicher, Kristin D.; Jamison, Timothy F. published the artcile< A reductive coupling strategy towards ripostatin A>, COA of Formula: C6H10O5, the main research area is ripostatin A synthesis reductive coupling enyne epoxide; catalysis; natural product; nickel; reductive coupling; ripostatin A; synthesis.

Synthetic studies on the antibiotic natural product ripostatin A have been carried out with the aim to construct the C9-C10 bond by a nickel(0)-catalyzed coupling reaction of an enyne and an epoxide, followed by rearrangement of the resulting dienylcyclopropane intermediate to afford the skipped 1,4,7-triene. A cyclopropyl enyne fragment, I, corresponding to C1-C9 has been synthesized in high yield and demonstrated to be a competent substrate for the nickel(0)-catalyzed coupling with a model epoxide. Several synthetic approaches toward the C10-C26 epoxide have been pursued. The C13 stereocenter can be set by allylation and reductive decyanation of a cyanohydrin acetonide. A mild, fluoride-promoted decarboxylation enables construction of the C15-C16 bond by an aldol reaction. The product of this transformation, ketone II, is of the correct oxidation state and potentially three steps removed from the targeted epoxide fragment.

Beilstein Journal of Organic Chemistry published new progress about Reductive coupling reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, COA of Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhihua; Zhu, Guofeng; Sheng, Chunpeng; Lei, Jianwei; Song, Sihui; Zhu, Jianming published the artcile< Hispidulin Enhances Temozolomide (TMZ)-Induced Cytotoxicity against Malignant Glioma Cells In Vitro by Inhibiting Autophagy.>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Temozolomide (TMZ), an oral alkylating agent, is the widely used first-line chemotherapeutic reagent for glioma in clinical practice. However, TMZ-induced autophagy is another cellular process favoring glioma cell survival. This study aimed to explore whether hispidulin can facilitate TMZ-induced cell death of glioma. The MTT assay showed that coadministration with hispidulin and TMZ could significantly decrease the viability of glioma U87MG cells. Meanwhile, hispidulin administration was also observed to promote TMZ-induced apoptosis. Furthermore, additional hispidulin treatment further elevated TMZ-induced expression of Bax, cleaved-caspase-9, and cleaved-caspase-3 protein but decreased Bcl-2 protein expression in U87MG cells. We also observed that hispidulin suppressed TMZ-induced autophagy to promote apoptosis, as showed by decreased AVOs and LC3B-I/II protein expression. These results collectively suggested that the combination of hispidulin and TMZ could improve the antitumor efficiency of TMZ against malignant gliomas.

Computational intelligence and neuroscience published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Xin; Cui, Lijuan; Zhang, Yushan; Guo, Chao; Deng, Lijiao; Wen, Zhitong; Lu, Zhihong; Shi, Xiaoyuan; Xing, Haojie; Liu, Yunfeng; Zhang, Yi published the artcile< Screening for potential therapeutic agents for non-small cell lung cancer by targeting ferroptosis>, COA of Formula: C15H22N2O2, the main research area is NSCLC ferroptosis therapeutic agent screening target.

Ferroptosis is a form of non-apoptotic and iron-dependent cell death originally identified in cancer cells. Recently, emerging evidence showed that ferroptosis-targeting therapy could be a novel promising anti-tumor treatment. However, systematic analyses of ferroptosis-related genes for the prognosis of non-small cell lung cancer (NSCLC) and the development of antitumor drugs exploiting the ferroptosis process remain rare. This study aimed to identify genes related to ferroptosis and NSCLC and to initially screen lead compounds that induce ferroptosis in tumor cells. We downloaded mRNA expression profiles and NSCLC clin. data from The Cancer Genome Atlas database to explore the prognostic role of ferroptosis-related genes. Four prognosis-associated ferroptosis-related genes were screened using univariate Cox regression anal. and the lasso Cox regression anal., which could divide patients with NSCLC into high- and low-risk groups. Then, based on differentially expressed risk- and ferroptosis-related genes, the neg. correlated lead compound flufenamic acid (FFA) was screened through the Connective Map database. This project confirmed that FFA induced ferroptosis in A549 cells and inhibited growth and migration in a dose-dependent manner through CCK-8, scratch, and immunofluorescence assays. In conclusion, targeting ferroptosis might be a therapeutic alternative for NSCLC.

Frontiers in Molecular Biosciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (CISD1). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, COA of Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics