Month: November 2022

Serafim, Rodolfo Bortolozo; Cardoso, Cibele; Arfelli, Vanessa Cristina; Valente, Valeria; Archangelo, Leticia Frohlich published the artcile< PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is GLI1 PIMERG DNA damage glioblastoma; ATM; ATR; DNA damage response; GBM; Gliomas; Temozolomide resistance.

PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, PIMREG expression is prominent in the central nervous system. Recent studies have described elevated PIMREG expression in different types of tumors, which correlates with patient survival and tumor aggressiveness. Given the emerging significance of PIMREG in carcinogenesis and its putative role in the context of the nervous system, we investigated the expression and function of PIMREG in gliomas, the most common primary brain tumors. We performed an extensive anal. of PIMREG expression in tumors samples from glioma patients. We then assessed the effects of PIMREG silencing and overexpression on the sensitivity of glioblastoma cell lines treated with genotoxic agents commonly used for treating patients and assessed for treatment response, proliferation and migration. Our anal. shows that glioblastoma exhibits the highest levels of PIMREG expression among all cancers analyzed and that elevated PIMREG expression is a biomarker for glioma progression and patient outcome. Moreover, PIMREG is induced by genotoxic agents, and its silencing renders glioblastoma cells sensitive to temozolomide treatment and affects ATR- and ATM-dependent signaling. Our data demonstrate that PIMREG is involved in DNA damage response and temozolomide resistance of glioblastoma cells and further supports a role for PIMREG in tumorigenesis.

Biochimica et Biophysica Acta, Molecular Basis of Disease published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jonsson, Erlendur; Ellison, James H. J.; Wang, Evelyna; Kunz, Vera; Liu, Tao; Temprano, Israel; Grey, Clare P. published the artcile< On the solvation of redox mediators and implications for their reactivity in Li-air batteries>, Reference of 112-63-0, the main research area is triethylphosphine oxide tetraglyme solvation lithium air battery.

Lithium-air batteries are a promising energy storage technol. for transport applications, given their exceptionally high energy d. However, their development is significantly hampered by high overpotentials, which lead to poor efficiency and short lifetimes. Redox mediators provide a solution to this problem by shuttling electrons from the electrode to the active species at just above the redox potential of the mediator. Thus, knowing the redox potential and having the ability to tune it are critical to electrochem. performance. We focus on LiI as a model mediator-given its addnl. role in controlling LiOH vs Li2O2 chem.-and use cyclic voltammetry (CV), NMR, UV/Vis spectrometry, and mol. dynamics (MD) simulations to monitor the effects of electrolyte composition on solvation. Li+ and I- solvation in common Li-air solvents, the electrochem. implications, and the applicability of each technique to probe the nature of the solvation shell and its effect on the electrochem. properties are explored. Starting with a simple thermodn. model, we then used UV/Vis spectrometry to probe I- solvation, 1H NMR spectroscopy to study water solvation and 31P of the probe mol. triethylphosphine oxide (TEPO) to explore Li+ solvation; we find that no single descriptor can provide an accurate description of the solvation environment. Instead, we use all these methods in combination with the MD results to help rationalize the CV data. We find that the I- solvation improves significantly in tetraglyme (G4), with increasing salt and water concentration, but minimal effects on changing salt/water concentrations are seen in DMSO. In contrast, increasing salt concentration increases the Li+ activity in DMSO but not in G4. Furthermore, a simple model considering the equilibrium between the different species was used to explain the 1H NMR data.

Journal of the Electrochemical Society published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Flores-Romero, Hector; Hohorst, Lisa; John, Malina; Albert, Marie-Christine; King, Louise E.; Beckmann, Laura; Szabo, Tamas; Hertlein, Vanessa; Luo, Xu; Villunger, Andreas; Frenzel, Lukas P.; Kashkar, Hamid; Garcia-Saez, Ana J. published the artcile< BCL-2-family protein tBID can act as a BAX-like effector of apoptosis>, Application of C15H22N2O2, the main research area is tBID BAX BCL2 BCL2A1 TRAIL immunity Shigella necrosulfonamide apoptosis; BCL-2 proteins; apoptosis; mitochondrial permeabilization; pore formation.

During apoptosis, the BCL-2-family protein tBID promotes mitochondrial permeabilization by activating BAX and BAK and by blocking anti-apoptotic BCL-2 members. Here, we report that tBID can also mediate mitochondrial permeabilization by itself, resulting in release of cytochrome c and mitochondrial DNA, caspase activation and apoptosis even in absence of BAX and BAK. This previously unrecognized activity of tBID depends on helix 6, homologous to the pore-forming regions of BAX and BAK, and can be blocked by pro-survival BCL-2 proteins. Importantly, tBID-mediated mitochondrial permeabilization independent of BAX and BAK is physiol. relevant for SMAC release in the immune response against Shigella infection. Furthermore, it can be exploited to kill leukemia cells with acquired venetoclax resistance due to lack of active BAX and BAK. Our findings define tBID as an effector of mitochondrial permeabilization in apoptosis and provide a new paradigm for BCL-2 proteins, with implications for anti-bacterial immunity and cancer therapy.

EMBO Journal published new progress about Ablation (genetic ablation). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhaoyan; Tian, Fangyuan; Chen, Xi published the artcile< Cost-Effectiveness Analysis of a Three-Drug Regimen Containing Bevacizumab for the Treatment of Recurrent Pediatric Medulloblastoma in China: Based on a COG Randomized Phase II Screening Trial.>, Application of C19H34O2, the main research area is bevacizumab; cost-effectiveness; irinotecan; recurrent pediatric medulloblastoma; temozolomide.

Background: Medulloblastoma is the most common malignant brain tumor of childhood, accounting for 6 to 7 percent of all childhood CNS tumors. The purpose of this study was to evaluate the economic efficacy of a bevacizumab combined with temozolomide + irinotecan regimen for the treatment of recurrent pediatric medulloblastoma in China. Methods: The data analyzed were from a randomized phase II screening trial that showed an improved survival benefit in child patients with recurrent medulloblastoma treated with a T+I+B combination regimen. A Markov model is constructed to estimate the incremental cost-effectiveness ratio (ICER) from the perspective of Chinese society. The uncertainty in the model is solved by one-way certainty and probabilistic sensitivity analysis. Results: Our base case analysis showed that the total costs of treatment increased from $8,786.403 to $27,603.420 with the combination bevacizumab vs. the two-agent chemotherapy regimen. Treatment with T+I+B combination therapy was associated with an increase in effectiveness of 0.280 QALYs from 0.867 to 1.147 QALYs T+I regimen. The incremental cost-effectiveness ratio was $67,203.632/QALY, which exceeded our pre-specified willingness-to-pay threshold ($38,136.26/QALY). Cost changes associated with grade 3-4 AE management, tests used, or hospitalization costs had little effect on the ICER values predicted by sensitivity analysis. Conclusions: Taken together, the results of this study suggest that the combination of bevacizumab with temozolomide and irinotecan is not a cost-effective option from the perspective of Chinese payers as a first-line treatment option for children with recurrent medulloblastoma in China.

Frontiers in public health published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palomba, Martina; Sancineto, Luca; Marini, Francesca; Santi, Claudio; Bagnoli, Luana published the artcile< A domino approach to pyrazino-indoles and -pyrroles using vinyl selenones>, Category: esters-buliding-blocks, the main research area is indolecarboxamide pyrrolocarboxamide chemoselective regioselective Michael reaction cyclization vinyl selenone; pyrazinoindolone dihydro preparation; pyrrolopyrazinone dihydro preparation.

An efficient and flexible approach to biol. relevant 3,4-dihydropyrazino[1,2-a]indol-1(2H)ones I [R1 = H, F, Cl, MeO, R2 = H; R1 = R2 = MeO; R3 = n-Bu, Ph, PhCH2, (R)-PhCHMe, etc.; R4 = H, Me, n-Bu, n-hexyl] and 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)ones through a domino Michael/intramol. nucleophilic substitution pathway using potassium hydroxide in dichloromethane is disclosed. Variously substituted vinyl selenones R4CH:CHSeO2Ph and 1H-indole-2-carboxamides II or 1H-pyrrole-2-carboxamides were employed with success in chemo- and regioselective processes. The introduction of an amino acid portion on the amidic function is well tolerated without racemization.

Tetrahedron published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Long; Wei, Yin; Shi, Min published the artcile< Asymmetric substitutions of O-Boc-protected Morita-Baylis-Hillman adducts with pyrrole and indole derivatives>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Boc Morita Baylis Hillman adduct pyrrole indole asym substitution.

An efficient asym. substitution process of O-Boc-protected Morita-Baylis-Hillman adducts with various pyrrole and indole derivatives has been developed in the presence of (DHQD)2PYR in THF, affording the corresponding products, e.g. I, in good to high yields (up to 99% yield) and moderate to high ee values (up to 92 and 96% ee) under mild conditions.

Organic & Biomolecular Chemistry published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iliyasov, Taigib M.; Karpenko, Kirill A.; Akulinin, Alexander S.; Fakhrutdinov, Artem N.; Korolev, Viktor A.; Elinson, Michail N.; Vereshchagin, Anatoly N. published the artcile< Stereoselective one-pot five-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines with two and three stereocenters>, Name: Ethyl 3-oxo-3-phenylpropanoate, the main research area is polysubstituted tetrahydropyridine preparation stereoselective; aldehyde ester oxocarboxylic acid one pot five component reaction.

A novel five-component stereoselective synthesis of polysubstituted tetrahydropyridines is reported. The Knoevenagel condensation – Michael addition – Mannich reaction – cyclization – dehydration cascade of aldehydes, esters of 3-oxocarboxylic acids C-H acids and ammonium acetate provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine-3-carboxylates with two stereocenters and 3,5-dialkyl (4RS,5SR,6RS)-5-cyano-2,4,6-triaryl-1,4,5,6-tetrahydropyridine-5,3-carboxylates with three stereocenters in 57-84% yields. It was established that formation of products proceeds via substituted 2-hydroxypiperidines with four stereocenters. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Five bonds are formed as a result of multicomponent process. The formation of single diastereomers was confirmed by singe crystal X-ray diffraction studies and 2D-NMR spectroscopy.

ARKIVOC (Gainesville, FL, United States) published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Name: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Xing; Shan, Chunhui; Chen, Zhihao; Liu, Yan; Zhao, Xia; Zhang, Ao; Yu, Peng; Galons, Herve; Lan, Yu; Lu, Kui published the artcile< One-pot synthesis of β-lactams by the Ugi and Michael addition cascade reaction>, Application In Synthesis of 112-63-0, the main research area is lactam beta preparation chemoselective diastereoselective; heterocyclic aldehyde amine isocyanide maleic fumaric acid; tandem Ugi Michael addition.

Synthesis of β-lactams I (R1 = COOMe, COOEt; R2 = n-Pr, 4-MeC6H4, 4-O2NC6H4, 4-ClC6H4; R3 = COOEt, COPh, 2-pyridyl, etc.; R4 = n-Bu, t-Bu, c-hexyl, Bn) was achieved via Ugi/Michael reaction cascades under mild conditions. The intramol. hydrogen bonding between the heteroatom from an aldehyde component and the amide NH group controls the chemoselectivity of the Michael reaction vs. the aza-Michael reaction. DFT calculation was performed to clarify the mechanism, chemo-selectivity and diastereoselectivity of this work. This one-pot protocol offers a straightforward method to build a diversified β-lactam library for drug discovery.

Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia da Silva, Artur Christian; Rodrigues, Bruna dos Santos; Andrade, Wanessa Machado; Marques dos Santos, Thais Rosa; de Carvalho, Flavio Silva; Sanz, German; Vaz, Boniek G.; Liao, Luciano M.; Menegatti, Ricardo; Valadares, Marize Campos published the artcile< Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells>, COA of Formula: C19H34O2, the main research area is Nutlin analog antiangiogenic antitumoral agent melanoma cell; Antitumor drugs; Apoptosis; LQFM126; Melanoma; Molecular simplification; Nutlins.

Inhibition of mouse double minute 2 homolog (MDM2)-p53 interaction and reactivation of p53 signaling have been explored as effective anticancer therapeutic strategy. The potent and specific antitumor activity shown by Nutlins, first class of MDM2-p53 inhibitors discovered, has made these compounds potential antitumor candidates. To this end, we synthesized Nutlin-1 and Nutlin-2 analogs through mol. simplification and selected the compound with the most efficient antitumoral activity. Cytotoxicity of Nutlin-2 analog LQFM126 on B16F10 melanoma cells induced intense cytoplasmic vacuolization, reduction of cell size, chromatin condensation, cytoplasmic degeneration and nuclear fragmentation. LQFM126 antiproliferative effects mediated cell cycle retention in G0/G1 phase and increased the levels of cell cycle regulatory proteins p21 and p27. This Nutlin analog increased mitochondrial membrane potential, activated caspase-8, -9 and -3/7 and reduced VEGF levels in B16F10 cells. Therefore, LQFM126 promoted alterations suggestive of apoptosis, G0/G1 cell cycle arrest and suppression of angiogenesis through modulation of VEGF expression in B16F10 cells. Addnl., LQFM126 was classified as UN GHS category 4 (LD50 > 300-2000 mg/kg), suggesting it has low acute systemic toxicity. LQFM126 can be a promising prototype for anticancer therapy.

Chemico-Biological Interactions published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Weihua; Jiang, Zhigan; He, Haiying; Xiao, Fubiao; Lin, Fusen; Sun, Ya; Hou, Lijuan; Shen, Liang; Han, Lixia; Zeng, Minggao; Lai, Kunmin; Gu, Zhengxian; Chen, Xinsheng; Zhao, Tao; Guo, Li; Yang, Chun; Li, Jian; Chen, Shuhui published the artcile< Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection>, Electric Literature of 30095-98-8, the main research area is spiro azetidine indoline fusion inhibitor respiratory syncytial virus.

A new series of 3,3′-spirocyclic 2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which exhibited excellent in vitro potency with an EC50 value of 0.8 nM and demonstrated 71% oral bioavailability in mice. In a mouse challenge model of RVS infection, 14h demonstrated superior efficacy with a 3.9log RSV virus load reduction in the lung following an oral dose of 50 mg/kg.

ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics