Month: November 2022

Fuladi, Shadi; Gholivand, Hamed; Ahmadiparidari, Alireza; Curtiss, Larry A.; Salehi-Khojin, Amin; Khalili-Araghi, Fatemeh published the artcile< Multicomponent Phase Separation in Ternary Mixture Ionic Liquid Electrolytes>, SDS of cas: 112-63-0, the main research area is phase separation mixture ionic liquid solvent lithium salt MD.

We investigate the phase behavior of ternary mixtures of ionic liquid, organic solvent, and lithium salt by mol. dynamics simulations. We find that at room temperature, the electrolyte separates into distinct phases with specific compositions; an ion-rich domain that contains a fraction of solvent mols. and a second domain of pure solvent. The phase separation is shown to be entropy-driven and is independent of lithium salt concentration Phase separation is only observed at microsecond time scales and greatly affects the transport properties of the electrolyte.

Journal of Physical Chemistry B published new progress about Diffusion (of Li+). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ye, Yang; Li, Xue; Feng, Guoquan; Ma, Ying; Ye, Fen; Shen, Haijun; Sun, Kang; Lu, Rongzhu; Miao, Shuhan published the artcile< 3,3'-Diindolylmethane induces ferroptosis by BAP1-IP3R axis in BGC-823 gastric cancer cells>, Formula: C15H22N2O2, the main research area is BAP1 IP3R anticancer agent gastric cancer.

To investigate the effect and potential mechanism of 3,3-diindolylmethane (DIM) on ferroptosis against gastric cancer, cells proliferation, lipid reactive oxygen species (ROS) and GSH level were measured in the BGC-823 gastric cancer cells after DIM treatment. Western blotting was used to detect the expression of SLC7A11, GPX4, IP3R and BAP1. Results showed that DIM could induce ferroptosis in the BGC-823 gastric cancer cells via upregulating lipid-ROS level and decreasing GSH generation. Besides, DIM also significantly reduced the protein level of SLC7A11 and GPX4, which was an important regulator of ferroptosis. In addition, DIM promoted the protein level of BAP1 and IP3R in a concentration-dependent manner in the BGC-823 gastric cancer cells. The knockdown of BAP1 could reduce IP3R level and DIM-induced ferroptosis of gastric cancer cells. Taken together, these results indicated that DIM could induce ferroptosis to exert anti-cancer effects via BAP1-IP3R axis, suggesting its effective therapeutic potential in gastric cancer.

Anti-Cancer Drugs published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Costales, Paula; Rios-Lombardia, Nicolas; Lorenzo-Herrero, Seila; Moris, Francisco; Gonzalez-Sabin, Javier published the artcile< Novel chiral naphthalimide-cycloalkanediamine conjugates: Design, synthesis and antitumor activity>, Category: esters-buliding-blocks, the main research area is naphthalimide cycloalkanediamine conjugate diastereoselective preparation DNA photocleavage antitumor SAR; apoptosis naphthalimide cycloalkanediamine conjugate diastereoselective preparation; Apoptosis; Cycloalkanediamine; Cytotoxicity; Naphthalimide; Structure-activity relationship.

A novel series of enantiopure naphthalimide-cycloalkanediamine conjugates I [n = 1,2], II [R = H, NO2; X = 2,4], III, IV were designed, synthesized starting from 1,8-naphthalic anhydride and evaluated for in vitro cytotoxicity against human colon adenocarcinoma (LoVo), human lung adenocarcinoma (A549), human cervical carcinoma (Hela) and human promyelocytic leukemia cell lines (HL-60). The cytotoxicity of the compounds I, II, III and IV was highly dependent on size and relative stereochem. of the cycloalkyl ring as well as length of the spacer. By contrast, any kind of enantioselection was observed for each pair of enantiomers. Flow cytometric anal. indicated that compounds II [R = NO2; n = 2] could effectively induced G2/M arrest in the four previous cell lines despite a mild apoptotic effect.

Bioorganic Chemistry published new progress about Antitumor agents. 364385-54-6 belongs to class esters-buliding-blocks, and the molecular formula is C11H22N2O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Jianjian; Wang, Bo; Hao, Aiyou; Xing, Pengyao published the artcile< Arene-perfluoroarene interaction induced chiroptical inversion and precise ee% detection of chiral acids in a benzimidazole-involved ternary coassembly>, HPLC of Formula: 112-63-0, the main research area is pyrenecarboxylate octafluoronaphthalene hydrogen bond chiral recognition CD.

Flexible regulation of chirality and handedness of chiral functional materials and quant. sensing of natural chiral compounds remains a considerable challenge. Herein, an achiral fluorescent 1-pyrenecarboxylic acid-benzimidazole derivative (PBI) was synthesized and its chiroptical properties upon coassembly with chiral acids (TA and MA) and octafluoronaphthalene (OFN) through hydrogen bonds between benzimidazole and chiral acids as well as an arene-perfluoroarene (AP) interaction between a pyrene moiety and OFN were systemically studied. The binary assemblies of PBI/TA and PBI/MA displayed opposite chiroptical properties including CD and circularly polarized luminescence (CPL) signals. Interestingly, the handedness of CPL was further inverted in ternary assemblies due to the synergistic effect of the AP interaction and hydrogen bonds. Besides, the highly accurate chiral sensing of chiral acids via binary assemblies was successfully achieved with a high correlation coefficient This work provides a simple method for regulating the handedness of chiroptical active materials and quant. sensing of chiral acids through orthogonal multiple component coassemblies.

Nanoscale published new progress about Binary systems. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bates, Gareth W.; Triyanti; Light, Mark E.; Albrecht, Markus; Gale, Philip A. published the artcile< 2,7-Functionalized Indoles as Receptors for Anions>, Product Details of C19H34O2, the main research area is indole carboxamide amido ureido thioureido preparation structure anion complexation; stability constant phosphate carboxylate chloride amido ureido thioureido indolecarboxamide; titration NMR anion complexation indolecarboxamide amido ureido thioureido derivative; hydrogen bond phosphate carboxylate indolecarboxamide amido ureido thioureido derivative; crystal structure indolecarboxamide amido ureido thioureido derivative; mol structure indolecarboxamide amido ureido thioureido derivative.

A series of 7-amido- and 7-ureido- and 7-thioureido-1H-indole-2-carboxamide derivatives were prepared by reduction and acylation of the corresponding 7-nitro-1H-indolecarboxamides; the compounds exhibit binding properties towards dihydrophosphate, acetate, benzoate and chloride ions. Amidation of 7-nitro-1H-indole-2-carboxylic acid by amines RNH2 gave N-R-7-nitro-1H-indole-2-carboxamides (8a,b; R = Bu, Ph), which were reduced to the corresponding N-R-7-amino-1H-indole-2-carboxamides (9a,b). Reaction of 9a,b with BuCOCl, PhCOCl, PhCH2COCl, BuNCO, PhNCO and PhNCS gave N-R-7-R1NH-1H-indole-2-carboxamides (1 R = Bu, R1 = BuCO; 2 R = Ph, R1 = PhCO; 3 R = Ph, R1 = PhCH2CO; 4 R = Bu, R1 = BuNHCO; 5 R = Ph, R1 = PhNHCO, 6 R = Ph, R1 = PhNHCS). Stability constants were measured in aqueous solution for complexation of 1-6 with H2PO4-, MeCO2-, PhCO2- and Cl- anions. Anion complexation studies show a marked difference in the mode of interaction of carboxylates with indole-ureas vs. indole-amides.

Journal of Organic Chemistry published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reinerte, Sanita; Avotina, Liga; Zarins, Arturs; Cabulis, Ugis; Viksna, Arturs published the artcile< TG/DTA-FTIR as a method for analysis of tall oil based rigid polyurethane foam decomposition gaseous products in a low oxygen environment>, HPLC of Formula: 112-63-0, the main research area is tall oil rigid polyurethane foam decomposition gaseous oxygen.

This study is an investigation of the suitability of the thermogravimetry and DTA method coupled with Fourier Transform IR spectrometry (TG/DTA-FTIR) for a thermal degradation gaseous product anal. of a rigid polyurethane-polyisocyanurate (PU-PIR) foam synthesized from high functionality tall oil fatty acids (TOFA) based polyols. The FTIR spectra of the TG-generated gaseous thermal degradation products of three PU-PIR formulations with varied high functionality TO based polyol content (45, 75 and 95 pbw) and a different tier of isocyanate (NCO) indexes (110, 150, 200, 300 and 400) for each formulation were compared to the spectra of a formulation developed using conventional raw materials. The chem. bands of known chem. compounds and unknown compounds containing specific groups for the foams were evaluated; the focus was on the maximum release rate for specific chem. compounds (CO2; -NCO; H2O; C=O) to determine the temperature zone values of the main thermal degradation phases. The experiments were carried out at a low oxygen environment, providing valuable data on the trends for the excretion of specific gaseous substances from the rigid PU-PUR foam that could be released in a real fire, where organic building materials that possess a porous matrix might be present and the nature of the combustion process is predominantly heterogeneous oxidation

Polymer Degradation and Stability published new progress about Combustion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Durie, Karson; Razavi, Mir Jalil; Wang, Xianqiao; Locklin, Jason published the artcile< Nanoscale Surface Creasing Induced by Post-polymerization Modification>, Computed Properties of 71195-85-2, the main research area is fluoro containing polymer brush postmodification creasing; nanoscale creasing; polymer brushes; post-polymerization modification.

Creasing in soft polymeric films is a result of substantial compressive stresses that trigger instability beyond a critical strain and have been directly related to failure mechanisms in different materials. However, it has been shown that programming these instabilities into soft materials can lead to new applications, such as particle sorting, deformable capillaries, and stimuli-responsive interfaces. In this work, we present a method for fabricating reproducible nanoscale surface instabilities using reactive microcontacting printing (μCP) on activated ester polymer brush layers of poly(pentafluorophenyl acrylate). The sizes and structures of the nanoscale creases can be modulated by varying the grafting d. of the brush substrate and pressure applied during μCP. Stress is generated in the film under confinement due to the mol. weight increase of the side chains during post-polymerization modification, which results in substantial in-plane growth in the film and leads to the observed nanoscale creases.

ACS Nano published new progress about Adhesion, physical. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Qiling; Hao, Nan; Zhao, Lili; Yang, Xiangke; Yuan, Yuxin; Zhao, Yuzhu; Wang, Fu; Qiu, Zuobing; He, Ling; Shi, Kan; Liu, Shuwen published the artcile< Comparative functional analysis of malate metabolism genes in Oenococcus oeni and Lactiplantibacillus plantarum at low pH and their roles in acid stress response>, SDS of cas: 112-63-0, the main research area is Oenococcus Lactiplantibacillus pH acid stress response malate metabolism gene; Lactiplantibacillus plantarum; Malate metabolism; Malic enzyme; Malolactic enzyme; Oenococcus oeni.

Oenococcus oeni and Lactiplantibacillus plantarum are major wine-associated lactic acid bacteria that pos. influence wine by carrying out malolactic fermentation O. oeni is the most widely used com. starter in winemaking because of its fast and efficient malate metabolism capacity under harsh wine conditions. To date, very little is known about the specific mol. mechanism underlying the differences in malate metabolism between O. oeni and L. plantarum under harsh wine conditions. Therefore, in this study, the functions of genes encoding malic enzyme (ME) and malolactic enzyme (MLE) under acid stress in O. oeni and L. plantarum, previously described to have the ability to direct malate metabolism, were comparatively verified through genetic manipulation in L. plantarum. Results showed that the MLE was the only enzyme responsible for direct malate metabolism under acid stress in O. oeni and L. plantarum. In addition, the MLEs in O. oeni and L. plantarum were pos. related to acid tolerance by metabolizing malate and increasing the medium pH. Furthermore, the MLE in O. oeni exhibited significantly higher malate metabolism activity than that in L. plantarum under acid stress.

Food Research International published new progress about Cell viability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Zhiwei; Liu, Xiaofeng; Liu, Juntao; Tao, Jingchao published the artcile< Highly enantioselective Michael addition catalyzed by new primary amine-squaramide organocatalysts>, Electric Literature of 112-63-0, the main research area is enantioselective Michael addition primary amine squaramide organocatalyst.

The asym. Michael addition reaction of α,α-disubstituted aldehydes to maleimides catalyzed by new bifunctional primary amine-squaramides has been developed. This organocatalytic asym. reaction provides easy access to functionalized succinimides with a broad substrate scope. Both enantiomers of desired succinimide derivatives were obtained in good to excellent yields (up to 98%) with excellent enantioselectivities (up to > 99% ee).

Youji Huaxue published new progress about Michael reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rehman, Fawad Ur; Liu, Yang; Yang, Qingshan; Yang, Haoying; Liu, Runhan; Zhang, Dongya; Muhammad, Pir; Liu, Yanjie; Hanif, Sumaira; Ismail, Muhammad; Zheng, Meng; Shi, Bingyang published the artcile< Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma synergistic therapy heme oxygenase exosome; Exosome; Glioblastoma; HMOX1; Temozolomide resistance; siRNA.

Glioblastoma (GBM) is a highly fatal and recurrent brain cancer without a complete prevailing remedy. Although the synthetic nanotechnol.-based approaches exhibit excellent therapeutic potential, the associated cytotoxic effects and organ clearance failure rest major obstacles from bench to clinics. Here, we explored allogeneic bone marrow mesenchymal stem cells isolated exosomes (BMSCExo) decorated with heme oxygenase-1 (HMOX1) specific short peptide (HSSP) as temozolomide (TMZ) and small interfering RNA (siRNA) nanocarrier for TMZ resistant glioblastoma therapy. The BMSCExo had excellent TMZ and siRNA loading ability and could traverse the blood-brain barrier (BBB) by leveraging its intrinsic brain accumulation property. Notably, with HSSP decoration, the TMZ or siRNA encapsulated BMSCExo exhibited excellent TMZ resistant GBM targeting ability both in vitro and in vivo due to the overexpression of HMOX1 in TMZ resistant GBM cells. Further, the HSSP decorated BMSCExo delivered the STAT3 targeted siRNA to the TMZ resistant glioma and restore the TMZ sensitivity, consequently achieved the synergistically drug resistant GBM treatment with TMZ. Our results showed this biomimetic nanoplatform can serve as a flexible, robust and inert system for GBM treatment, especially emphasizing the drug resistant challenge.

Journal of Controlled Release published new progress about Antibiotic resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics