Month: November 2022

dos Santos Pedroso-Fidelis, Giulia; de Melo, Maria Eduarda; Possato, Jonathann Correa; Fernandes, Bruna Barros; De Pieri, Ellen; Cercena, Rodrigo; Dal-Bo, Alexandre Goncalves; Feuser, Paulo Emilio; Machado-de-Avila, Ricardo Andrez published the artcile< Temozolomide associated to gold nanoparticles promoted a synergic effect and apoptosis when exposed to melanoma cells>, Application In Synthesis of 112-63-0, the main research area is temozolomide gold nanoparticle synergic effect apoptosis melanoma.

Temozolomide (TMZ) is prescribed primarily because of its known ability to cross the blood-brain barrier, being a potentially chemotherapic drug for cancer treatment. However, it has dose-limiting hemotoxicity and rapid hydrolysis, which limits its anti-tumor efficacy. On the other hand, recent studies have shown that gold nanoparticles (GNPs) with their biocompatibility and cytotoxic potential in tumor cells can be combined with chemotherapy leading to an improvement in the existing treatment. Thus, this work aimed to evaluate the cytotoxic effects of TMZ associated with GNPs (T-GNPs) on B16F10 cells. Different GNPs were successfully synthesized, and the results showed that there was an electrostatic interaction between TMZ and GNPs, not changing their physicochem. properties. TMZ associated with GNPs exposed on B16F10 cells presented a cytotoxic effect even more pronounced than free TMZ. In addition, different T-GNPs did not induced cytotoxic effect on non-tumor cells (NIH3T3 and red blood cells). A synergism between TMZ and GNPs was observed, inducing B16F10 cell death by apoptosis.

Journal of Nanoparticle Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xingkuan; Fang, Xinqiang; Chi, Yonggui Robin published the artcile< cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity>, Reference of 112-63-0, the main research area is enal imine cyclization heterocyclic carbene; cyclic ketone stereoselective preparation; heterocyclic carbene stereoselective cyclization catalyst.

The first successful generation of cis-homoenolate equivalent from cis-enals under the catalysis of N-heterocyclic carbenes (NHCs) has been realized. The cis-homoenolate intermediates undergo effective reactions with α,β-unsaturated imines to afford chiral cyclic ketone products, e.g., I and II. Compared to the trans-enals, cis-enals show different stereoselectivities and new reactivity patterns.

Chemical Science published new progress about Cyclic ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alsubaiei, Sana Razhan M.; Alfawaz, Hanan A.; Amina, Musarat; Al Musayeib, Nawal M.; El-Ansary, Afaf; Ahamad, Syed Rizwan; Noman, Omar M.; Maini, Jaber A. published the artcile< Comparative chemical profiling and biological potential of essential oils of petal, choke, and heart parts of Cynara scolymus L. head>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cynara essential oil petal choke heart part antibacterial antioxidant.

The essential oil and macroelemental composition of different parts of flower bud (petal, choke, and heart) of Cynara scolymus L. were explored and compared using gas chromatog. mass spectrometry (GC-MS) and inductively coupled plasma mass spectrometry (ICP-MS). Overall, 62 organic components were detected in the flower bud based on mass spectra characteristics and retention indexes. The essential oil extracted from the petals, choke, and bud showed the presence of thirty-one, twenty-one, and twenty-one compounds, resp., with linoleic acid and palmitic acid as the major components. 21 components were identified in the oil of the petals, comprising 94.45% of the total oil, in which linoleic acid Me ester, palmitic acid Me ester, octadecanoic acid Me ester, O-α-d-glucopyranoside, and heptyl oct-3-yl ester were the major constituents. Twenty-one compounds, representing 89.13% of the total oil, were detected in the choke oil. Linoleic acid Me ester, palmitic acid Me ester, and 2-methyl-1-hexadecanol were the main components. However, the edible heart oil contains twenty compounds, comprising 86.84% of the total oil. Cyclopropane butanoic acid, linoleic acid, Me ester, and palmitic acid were the major constituents. The anal. executed by ICP-MS revealed the presence of significant amounts of various inorganic elements in all the three samples. The extracted essential oils were tested for antibacterial, antioxidant, and anticancer activities. The results showed that the oil extracted from the petals of C. scolymus flower bud displayed the highest antibacterial, antioxidant, anti-inflammatory, and anticancer effects, as compared to choke and heart oils.

Journal of Chemistry published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumari, P. Krishna; Rao, B. Srinivasa; Mallesh, D.; Lingaiah, N. published the artcile< Niobium exchanged tungstophosphoric acid supported on titania catalysts for selective synthesis of 5-ethoxymethylfurfural from fructose>, Application In Synthesis of 112-63-0, the main research area is ethoxymethylfurfural preparation titania support tungstophosphoric acid catalyst property.

Various niobium contained tungstophosphoric acid (NbTPA) supported on titania catalysts were prepared and investigated their activity for selective synthesis of 5-ethoxymethylfurfural (EMF) from fructose in ethanol/THF solvent system. Physico-chem. properties of the catalysts were assessed by different spectroscopic approaches like X-ray diffraction, Laser Raman, BET-surface area, FT-IR, pyridine adsorbed FT-IR and temperature programmed desorption of ammonia. The results of characterization direct the existence of firm Keggin ion structure of Nb exchanged TPA and its well dispersed state on support. Lewis acidic sites were induced with the existence of Nb ions. The catalytic activity was interrelated to the catalyst acidity which was liable on the number of Nb ions present in TPA and the amount of NbxTPA supported on TiO2. Among all catalysts 20wt% Nb0.4TPA/TiO2 catalyst showed best catalytic performance toward EMF with a yield of 76% at 130°C after 6 h. The catalyst is recyclable without any depletion of activity.

Molecular Catalysis published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhiqing; Lv, Junshuai; Xie, Guanglin; Wang, Su; Ye, Yanshuai; Huang, Gaohua; Tan, Donlgi published the artcile< Effect of assisted hydrogen on combustion and emission characteristics of a diesel engine fueled with biodiesel>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is methyl ester diesel engine fuel combustion emission simulation.

In this paper, the effects of hydrogen assisted biodiesel with different fatty acid Me esters (FAMEs) proportion on cylinder pressure, cylinder temperature, indicated thermal efficiency (ITE), NOx emission, HC emission and CO emission of a marine medium speed diesel engine are studied. The corresponding CFD model is executed by CONVERGE coupled to CHEMKIN, and a chem. kinetic mechanism with 314 reactions and 98 species is developed to accurately simulate the fuel injection and combustion processes. The results show that cylinder pressure, cylinder temperature and ITE increased with increasing HEF. Compared with rapeseed Me ester (RME) and cottonseed Me ester (CSME), the cylinder pressures are increased by 16.39% and 16.30% for CSME-6%H2 and RME-6%H2 at 100% load, resp. The cylinder temperatures are increased by 7.42% and 7.14%, and ITE increased by 3.73% and 3.9%, resp. In addition, the HC and CO emissions decreased significantly with the increase in HEF, while NOx emission increased. Compared with pure CSME and RME, HC emissions are reduced by 70.97% and 72.22% for CSME-6%H2 and RME-6% H2, and CO emissions are reduced by 41.89% and 38.12% for CSME-6%H2 and RME-6% H2 at 100% load, resp. Overall, the strategy of using CSME-6% H2 mixed fuel for engine is not only economical and practical, but also can prevent performance loss and reduce emissions.

Energy (Oxford, United Kingdom) published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Peng; Wang, Handong; Pan, Hao; Chen, Jiakai; Deng, Chulei published the artcile< Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway>, SDS of cas: 112-63-0, the main research area is glioblastoma anlotinib temozolomide JAK2 STAT3 signal transduction; Anlotinib; Glioblastoma; Invasion; JAK2/STAT3/VEGFA signaling pathway; Migration; Proliferation.

Anlotinib protects against carcinogenesis through the induction of autophagy and apoptosis. The current study evaluated the role and mol. mechanisms of anlotinib in glioblastoma, and the effects of anlotinib in combination with temozolomide (TMZ). Cell Counting Kit-8 and colony-forming assays were used to evaluate cell viability. Cell migration and invasion were assessed by wound-healing, Transwell migration, and Matrigel invasion assays. Cellular apoptosis and cell cycle anal. were determined by flow cytometry. Angiogenesis was assessed using human umbilical vein endothelial cells (HUVECs). Vascular endothelial growth factor A (VEGFA) was measured by ELISA. Protein expression was determined by western blotting or immunofluorescence staining. The in vivo anti-glioblastoma effect was assessed with live imaging of tumor xenografts in nude mice. Anlotinib restricted the proliferation, migration, and invasion of glioblastoma cells in a dose-dependent manner. Tumor supernatant from glioblastoma cells treated with anlotinib inhibited angiogenesis in HUVECs. Anlotinib induced autophagy in glioblastoma cells by increasing Beclin-1 and microtubule-associated protein 1 light chain 3B (LC3B) levels. Mechanistically, anlotinib inhibited the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3)/VEGFA signaling pathway. STAT3 inhibition by S3I-201 decreased VEGFA and suppressed cellular proliferation and movement. TMZ enhanced the anti-glioblastoma ability of anlotinib. Finally, anlotinib inhibited tumor growth and JAK2/STAT3/VEGFA signaling in xenografts. Anlotinib exerts anti-glioblastoma activity possibly through the JAK2/STAT3/VEGFA signaling pathway. TMZ potentiated the anti-glioblastoma effect of anlotinib via the same signaling pathway, indicating the potential application of anlotinib as a treatment option for glioblastoma.

Cancer Chemotherapy and Pharmacology published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Di Iorio, Nicola; Champavert, Florian; Erice, Agostino; Righi, Paolo; Mazzanti, Andrea; Bencivenni, Giorgio published the artcile< Targeting remote axial chirality control of N-(2-tert-butylphenyl)succinimides by means of Michael addition type reactions>, Quality Control of 112-63-0, the main research area is remote axial chirality control Michael addition tertbutylphenylsuccinimide.

The efficient desymmetrization of N-(2-tert-butylphenyl)maleimides was realized by means of a Michael addition reaction of a series of carbon nucleophiles generating the corresponding axially chiral succinimides in high yields. The use of (DHQD)2Pyr as catalyst was fundamental to achieve the remote control of the stereogenic chiral axis with the concurrent construction of adjacent quaternary and tertiary stereocenters.

Tetrahedron published new progress about Atropisomers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kazmierczak, Jean C.; Cargnelutti, Roberta; Barcellos, Thiago; Silveira, Claudio C.; Schumacher, Ricardo F. published the artcile< Selective synthesis of α-organylthio esters and α-organylthio ketones from β-keto esters and sodium S-organyl sulfurothioates under basic conditions>, Formula: C11H12O3, the main research area is alpha organylthio ester preparation; preparation alpha organylthio ketone; beta keto ester sodium organyl sulfurothioate CS bond formation; Bunte salts; C–C bond cleavage; α-alkylthio esters; α-alkylthio ketones; β-keto esters.

A selective method to prepare α-organylthio esters RSCH2C(O)OR1 [R = (CH2)3CH3, Bn, 4-MeC6H4CH2, etc.; R1 = Me, Et, cyclohexyl, etc.] and α-organylthio ketones R2C(O)CH2SCH2R3 [R2 = Me, Ph; R3 = Bn, 2-MeC6H4CH2, 2-ClC6H4CH2, 4-ClC6H4CH2, 4-F3CC6H4CH2] by the reaction of β-keto esters with sodium S-benzyl sulfurothioate or sodium S-alkyl sulfurothioate (Bunte salts) under basic conditions in toluene as the solvent at 100°C was developed. When 4 equiv of a base were used, a series of differently substituted α-thio esters were obtained with up to 90% yield. On the other hand, employing 2 equiv of a base, α-thio ketones were achieved after 18 h under air. Furthermore, after a shorter reaction time, the isolation of keto-enol tautomers was possible, revealing them as significant intermediates for the mechanism elucidation.

Beilstein Journal of Organic Chemistry published new progress about C-C bond cleavage. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qiang; Tang, Xiang-Ying; Shi, Min published the artcile< Metal-Free Cross-Coupling of Arylboronic Acids and Derivatives with DAST-Type Reagents for Direct Access to Diverse Aromatic Sulfinamides and Sulfonamides>, Reference of 112-63-0, the main research area is aromatic sulfinamide sulfonamide preparation; arylboronic acid ester aminosulfur trifluoride cross coupling; arylboronic acids; cross-coupling; sulfinamides; sulfonamides; synthetic methods.

We have developed a simple and convenient method for the cross-coupling of arylboronic acids and their derivatives with DAST-type reagents under mild and metal-free conditions to directly afford sulfinamides in moderate to good yields. Moreover, sulfonamides were obtained after a simple oxidation reaction. The reaction mechanism was investigated by 18O-labeling experiments, and the synthetic utility was demonstrated by the sulfoxidation of natural products.

Angewandte Chemie, International Edition published new progress about Arenesulfonamides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; Rabeah, Jabor; Huan, Heming; Schuenemann, Volker; Brueckner, Angelika; Beller, Matthias published the artcile< Nanoscale Fe2O3-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iron oxide catalyst nitroarene selective hydrogenation recycling.

Production of anilines-key intermediates for the fine chem., agrochem., and pharmaceutical industries relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe2O3)-based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe2O3 particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.

Science (Washington, DC, United States) published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics