Month: November 2022

On December 29, 2011, Deng, Yongqi; Zhu, Liang; Shipps, Gerald W., Jr.; Lo, Sie-Mun; Sun, Binyuan; Huang, Xiaohua; Beinstock, Corey; Cooper, Alan B.; Gao, Xiaolei; Yao, Xin; Zhu, Hugh Y.; Kelly, Joseph M.; Boga, Sobhana Babu; Alhassan, Abdul-Basit; Tagat, Jayaram R.; Mansoor, Umar Faruk; Wilson, Kevin; O’Boyle, Brendan M.; Daniels, Matthew; Schell, Adam; Siliphaivanh, Phieng; Fischer, Christian published a patent.Application of 872046-08-7 The title of the patent was Indazolecarboxamide derivatives as ERK inhibitors and their preparation and use for the treatment of cancer. And the patent contained the following:

The invention relates to indazolecarboxamide derivatives of formula I, which are ERK inhibitors and which are useful in the treatment of cancer. Compounds of formula I wherein R is H, alkyl and hydroxyalkyl; R1 is (un)substituted heterocyclyl, (un)substituted heterocycloalkenyl, (un)substituted aryl and (un)substituted heteroaryl; R2 is H and alkyl; R3′ is (un)substituted piperidinyl, (un)substituted azepanyl, (un)substituted oxazepanyl, etc.; and pharmaceutically acceptable salts, solvates and esters thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their ERK inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of 14.4 nM and 28.1 nM towards cERK and aERK, resp. The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).Application of 872046-08-7

The Article related to indazolecarboxamide preparation erk inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 872046-08-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2011, Cyrus, Kedra; Wehenkel, Marie; Choi, Eun-Young; Han, Hyeong-Jun; Lee, Hyosung; Swanson, Hollie; Kim, Kyung-Bo published an article.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Impact of linker length on the activity of PROTACs. And the article contained the following:

Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations, a small mol.-based novel technol. termed “PROteolysis TArgeting ChimeraS (PROTACs)” has been developed, targeting proteins for degradation at the post-translational level. Despite the promising potential of PROTACs to serve as mol. probes of complex signaling pathways, their design has not been generalized for broad application. Here, we present the first generalized approach for PROTAC design by fine-tuning the distance between the two participating partner proteins, the E3 ubiquitin ligase and the target protein. As such, we took a chem. approach to create estrogen receptor (ER)-α targeting PROTACs with varying linker lengths and the loss of the ER in cultured cells was monitored via western blot and fluorometric analyses. We found a significant effect of chain length on PROTAC efficacy, and, in this case, the optimum distance between the E3 recognition motif and the ligand was a 16 atom chain length. The information gathered from this experiment may offer a generalizable PROTAC design strategy to further the expansion of the PROTAC toolbox, opening new possibilities for the broad application of the PROTAC strategy in the study of multiple signaling pathways. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to protein linker length breast cancer protac western blot fluorometry, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 1, 2014, Patane, Michael published a patent.Product Details of 141940-37-6 The title of the patent was Compositions and methods for treating or preventing diseases or disorders associated with misregulated eIF-4E. And the patent contained the following:

Disclosed herein are compounds, compositions, formulations, kits and methods of treatment useful for treating or preventing one or more hyperproliferative disorders, e.g., cancer or a neurol. disease or disorder. Compounds of formula I wherein each R1 is independently (halo)alkyl, Cl, etc.; R2 is OH, NH2, aryl, etc.; R3 is H, alkyl, halo, etc; R4 is (un)substituted aryl, etc.; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their anti-proliferative activity (some data given). The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Product Details of 141940-37-6

The Article related to thiazolylpyrazole preparation hyperproliferative cancer neurol eif4e, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2015, Patane, Michael published a patent.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e. And the patent contained the following:

Disclosed herein are compounds, compositions, formulations, kits and methods of treatment useful for treating or preventing one or more hyperproliferative disorders, e.g., cancer or a neurol. disease or disorder. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolylpyrazole preparation hyperproliferative cancer neurol eif4e, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2017, Resetco, Cristina; Dikic, Tamara; Verbrugge, Tom; Du Prez, Filip E. published an article.Formula: C4H8ClNOS The title of the article was UV-cured multifunctional coating resins prepared from renewable thiolactone derivatives. And the article contained the following:

A set of multifunctional UV-cured thiol-ene polymer resins were systematically prepared from thiolactone containing monomers and different amine compounds Aminolysis of the thiolactone moiety enabled the introduction of different side chains and crosslinkers into the polymers. The glass transition temperature of the polymers varied between 22 and 90°C, depending on the type and molar ratio of amine-containing compounds relative to the monomer. The properties of the UV-cured thin films were screened using standard tests for coatings, including pencil hardness, impact resistance, and cross-hatch adhesion. Thiolactone-derived polymer films exhibited high transparency of 90%, pencil hardness in the range of 3B-HB, high impact resistance >2 kg m, and good adhesion to steel in dry conditions. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Formula: C4H8ClNOS

The Article related to uv cured coating thiolactone pencil hardness impact resistance property, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yuxiao; Liu, Yu; Shanahan, Charles S.; Xu, Xichen; Doyle, Michael P. published an article in 2014, the title of the article was A survey of enol-diazo nucleophilicity in selective C-C bond forming reactions for the synthesis of natural product-like frameworks.Computed Properties of 707-07-3 And the article contains the following content:

A survey of in situ, catalytically generated carbocations for coupling with enol (diazo)acetate nucleophiles was performed. This coupling reaction facilitate a rapid assembly of complex organic diazo compounds that provide a template for the synthesis of a variety of carbocyclic and heterocyclic ring systems. Under optimized conditions the synthesis of the target compounds was achieved using scandium triflate (Lewis acid) as a catalyst for a reaction of 2-diazo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butenoic acid Me ester with α-(phenyl)benzenemethanol 1-acetate derivatives and orthoformate derivatives, such as 2,2′,2”-[methylidynetris(oxy)]tris[propane], tri-Me orthovalerate. The title compounds thus formed included α-(diazo)-β-(oxo)alkanoic acid esters, such as α-diazo-β-oxo-δ-(phenyl)benzenepentanoic acid Me ester. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Computed Properties of 707-07-3

The Article related to enol diazo nucleophile coupling reaction natural product like framework, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yoneda, Kozo; Hu, Yaping; Watanabe, Rei; Kita, Masaki; Kigoshi, Hideo published an article in 2016, the title of the article was Binding position analysis of target proteins with the use of amidopyrene probes as LA-LDI enhancing tags.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate And the article contains the following content:

Amidopyrene-conjugated compounds can be detected by label-assisted laser desorption/ionization mass spectrometry (LA-LDI MS) without matrixes. When actin, a cytoskeletal protein, was labeled with an excess amount of amidopyrene N-hydroxysuccinate (apy-OSu), eight apy-labeled actin peptides were predominantly detected by LA-LDI MS. Then actin was labeled with an amidopyrene NHS ester of the antitumor marine macrolide aplyronine A (ApA-apy-OSu) to form a 1 : 1 conjugate. The sequence of an apy-labeled peptide was established as A108PLNPKANR116 by MS/MS anal., in which the NHS ester moiety specifically reacted with the ε-amino group of K113. While the fragmentation at the linker part reduces the detection sensitivity of apy-labeled peptides on LA-LDI MS, our chem. probe method is useful for analyzing the binding modes of various ligands and target biomacromols. that include multiple and weak interactions. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to binding position analysis protein amidopyrene probe affinity labeling ms, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2009, Degnan, Andrew P.; Tora, George O.; Denhart, Derek J.; Vrudhula, Vivekananda M.; Macor, John E.; Bronson, Joanne J. published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of substituted heterocyclic ethers as inhibitors of NK-1 and SERT and their use in treating CNS disorders. And the patent contained the following:

The invention encompasses compounds of Formula I (wherein R1 is H or alkyl; R2 is H, alkyl, cyanoalkyl, haloalkyl, etc.; R3 is H or alkyl; Ar1 is substituted Ph or pyridinyl; Ar2 is substituted indolyl, indazolyl, benzimidazolyl, or benzotriazolyl), including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. The compounds of Formula I demonstrate inhibition of neurokinin-1 or serotonin reuptake or both and can be used therefore to treat conditions associated with aberrant levels of tachykinins or serotonin or both. Such conditions are anxiety, depression, obsessive compulsive disorder, bulimia, panic disorder, posttraumatic stress disorder, alc. dependence, or urinary incontinence. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by removing the protecting groups from the corresponding intermediate, had an NK-1 and SERT IC50 values of 0.01-100 nM in binding assays. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to preparation heterocyclic ether nk1 sert inhibitor cns disorder treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2009, Degnan, Andrew P.; Tora, George O.; Denhart, Derek J.; Vrudhula, Vivekananda M.; Macor, John E.; Bronson, Joanne J. published a patent.Synthetic Route of 141940-37-6 The title of the patent was Preparation of substituted heterocyclic ethers as inhibitors of NK-1 and SERT and their use in treating CNS disorders. And the patent contained the following:

The invention encompasses compounds of Formula I (wherein R1 is H or alkyl; R2 is H, alkyl, cyanoalkyl, haloalkyl, etc.; R3 is H or alkyl; Ar1 is substituted Ph or pyridinyl; Ar2 is substituted indolyl, indazolyl, benzimidazolyl, or benzotriazolyl), including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. The compounds of Formula I demonstrate inhibition of neurokinin-1 or serotonin reuptake or both and can be used therefore to treat conditions associated with aberrant levels of tachykinins or serotonin or both. Such conditions are anxiety, depression, obsessive compulsive disorder, bulimia, panic disorder, posttraumatic stress disorder, alc. dependence, or urinary incontinence. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by removing the protecting groups from the corresponding intermediate, had an NK-1 and SERT IC50 values of 0.01-100 nM in binding assays. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Synthetic Route of 141940-37-6

The Article related to preparation heterocyclic ether nk1 sert inhibitor cns disorder treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2018, Xiao, Kunhong; Zhao, Yang; Choi, Minjung; Liu, Hongda; Blanc, Adi; Qian, Jiang; Cahill, Thomas J. III; Li, Xue; Xiao, Yunfang; Clark, Lisa J.; Li, Sheng published an article.Application of 79642-50-5 The title of the article was Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping. And the article contained the following:

Many cellular functions necessitate structural assemblies of two or more associated proteins. The structural characterization of protein complexes using standard methods, such as X-ray crystallog., is challenging. Herein, we describe an orthogonal approach using hydrogen-deuterium-exchange mass spectrometry (HDXMS), crosslinking mass spectrometry (CXMS), and disulfide trapping to map interactions within protein complexes. HDXMS measures changes in solvent accessibility and hydrogen bonding upon complex formation; a decrease in HDX rate could account for newly formed intermol. or intramol. interactions. To distinguish between inter- and intramol. interactions, we use a CXMS method to determine the position of direct interface regions by trapping intermol. residues in close proximity to various crosslinkers (e.g., disuccinimidyl adipate (DSA)) of different lengths and reactive groups. Both MS-based experiments are performed on high-resolution mass spectrometers (e.g., an Orbitrap Elite hybrid mass spectrometer). The physiol. relevance of the interactions identified through HDXMS and CXMS is investigated by transiently co-expressing cysteine mutant pairs, one mutant on each protein at the discovered interfaces, in an appropriate cell line, such as HEK293. Disulfide-trapped protein complexes are formed within cells spontaneously or are facilitated by addition of oxidation reagents such as H2O2 or diamide. Western blotting anal., in the presence and absence of reducing reagents, is used to determine whether the disulfide bonds are formed in the proposed complex interface in physiol. relevant milieus. The procedure described here requires 1-2 mo. We demonstrate this approach using the β2-adrenergic receptor-β-arrestin1 complex as the model system. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application of 79642-50-5

The Article related to hdxms cxms disulfide trapping combining orthogonal approach protein complex, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Application of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics