Month: November 2022

On December 3, 2009, Matsukawa, Tatsuya; Masuzaki, Kazuhiro; Kawasaki, Akiko; Akasaka, Akiko; Kawai, Yosuke published a patent.Computed Properties of 86239-00-1 The title of the patent was Preparation of benzene or thiophene compounds as VAP-1 inhibitors for disease treatment. And the patent contained the following:

The present invention provides a novel benzene derivative or thiophene derivative of general formula I (wherein A1 is a residue derived from benzene or a heterocycle containing at least one nitrogen atom or sulfur atom; A2 is a divalent residue derived from optionally substituted benzene or optionally substituted thiophene; B1 is H, OH, halo, etc.; B2 is H or a functional group containing at least one nitrogen atom; or B1 and B2 together form a cyclic structure; Y is J-L-M; J is a bond, lower alkylene, etc.; L is a bond, O, etc.; M is a bond, lower alkylene, etc.; X is -(CH2)m-, -(CH2)m-O-, etc.; m is 0-6; D is -NR3-; R3 is H, lower alkyl, etc.; and E is optionally substituted amino) useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like. Synthetic procedures for preparing I are exemplified. Example compound II-2HCl, prepared in a multistep synthesis using 4-(5-bromopyridin-2-yl)morpholine as a starting material, had IC50 values of 20.8 and 1.1 nM in radiochem. enzyme assays that measured inhibitory effect on human and rat VAP-1 enzymes, resp. The experimental process involved the reaction of Ethyl 3-fluoro-4-methylbenzoate(cas: 86239-00-1).Computed Properties of 86239-00-1

The Article related to benzene thiophene compound preparation therapeutic vap1 inhibitor, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Computed Properties of 86239-00-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 29, 2019, Trivedi, Meeta; Peng, Fang; Xia, Xuhui; Sepulveda-Medina, Pablo I.; Vogt, Bryan D. published an article.Application of 3319-31-1 The title of the article was Control of pore size in ordered mesoporous carbon-silica by Hansen solubility parameters of swelling agent. And the article contained the following:

The cooperative assembly of functional precursors with block copolymers (BCPs) is a powerful, general route to fabricate ordered mesoporous materials, but the precise tuning of the mesopore size generally requires trial and error to obtain the correct BCP template or appropriate swelling agent. Here, we demonstrate the ability to effectively modulate both expansion and contraction of the ordered cylindrical mesopores relative to those obtained from cooperatively assembled Pluronic F127, resol, and tetraethylorthosilicate. The two key phys. parameters for the swelling agents are their hydrophobicity, as quantified by the octanol-water partition coefficient (Kow), and Hansen solubility parameters that describe the interactions of the solvent with the different components of the BCP template. Four low volatility solvents are examined that span a wide Kow with up to 90 wt % solvent relative to the Pluronic F127. Glycerol triacetate (Kow < 1) can decrease the average mesopore size from 5.9 to 4.8 nm due to segmental screening of the interactions in the Pluronic F127 to decrease chain stretching at intermediate loadings. A modest increase in mesopore size to 8.1 nm can be achieved with trimethylbenzene (TMB, Kow = 3.42). Dioctyl phthalate (DOP), which is slightly more hydrophobic (Kow = 8.1), is more effective than TMB at expanding the pore size (maximum: 13.5 nm) without loss of ordered structure. A more hydrophobic solvent, tris (2-ethylhexyl) trimellitate (Kow = 12.5), is less effective at increasing the pore size (maximum: 8.2 nm). The Hansen solubility parameters for DOP most closely match those of the hydrophobic segment in the Pluronic F217 template. We attribute this similarity, which is related to the solvent quality, to the improved efficacy of DOP in increasing the pore size. These results illustrate that both the Hansen solubility parameters (relative to the hydrophobic segment of the template) and relative hydrophobicity of the swelling agent determine the obtainable pore sizes in cooperatively assembled ordered mesoporous materials. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Application of 3319-31-1

The Article related to pore size mesoporous carbon silica hansen solubility swelling agent, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Application of 3319-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 1, 2020, Ye, Jianlong; Chu, Jiachen; Yin, Jian; Zhang, Yufeng; Meng, Jianqiang published an article.SDS of cas: 6038-19-3 The title of the article was Surface modification of regenerated cellulose membrane based on thiolactone chemistry – A novel platform for mixed mode membrane adsorbers. And the article contained the following:

Mixed-mode membrane chromatog. (MMC) is an efficient separation technol. for protein purification However, tedious preparation methods and difficulty on ligand d. control for its stationary phase limit the application of MMC. Herein we explored a one-pot multistep reaction based on the thiolactone chem. as a platform for membrane surface modification design toward mixed mode membrane adsorbers. The regenerated cellulose (RC) membrane was modified by the atom transfer radical polymerization (ATRP) of styrene-thiolactone (St-Tla), followed by the amine-thiol-ene conjugation. N-butylamine/methacrylic acid and octylamine/methacrylic acid were selected as the modifier to prepare two different mixed mode membrane adsorbers, RC-HIC/IEC (hydrophobic/ion-exchange) and RC-RPC/IEC (reversed phase/ion-exchange). SEM, FT-IR and XPS results showed that the membrane adsorbers were successfully prepared The RC-HIC/IEC membrane had a statistic adsorption capacity of 73.5μg/cm2 for human IgG (IgG) under the conditions of pH = 8 and 0.5 mol/L NaCl in PB buffer. The RC-RPC/IEC membrane showed a capacity of 70μg/cm2 for α-chymotrypsin (α-CTP) under the conditions of pH = 6.5 in PB buffer. The feasibility of tethering multi functions onto membrane surface via the thiolactone chem. was demonstrated in this work. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).SDS of cas: 6038-19-3

The Article related to surface modification cellulose membrane thiolactone adsorption adsorbent, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.SDS of cas: 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 8, 2015, Campos, Sebastien Andre; Harling, John David; Miah, Afjal Hussain; Smith, Ian Edward David published a patent.Computed Properties of 882518-89-0 The title of the patent was Benzothiophene derivatives as estrogen receptor inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to benzothiophene derivatives of formula I, which are estrogen receptor inhibitors and which are useful in the treatment of diseases mediated by the estrogen receptor. Compounds of formula I wherein R1 is H, OH, C1-3 alkoxy and halo; R2 is OH and C1-3 alkoxy; X is O and CO; L is a linker; R3 is (un)branched C1-6 alkyl and C3-6 cycloalkyl; R4 is 4-methylthiazol-5-yl, oxazol-5-yl and halo; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their estrogen receptor alpha (ERa) degradation (data not given). The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Computed Properties of 882518-89-0

The Article related to benzothiophene preparation estrogen receptor inhibitor treatment disease, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Computed Properties of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2018, Simonet-Davin, Raphael; Zard, Samir Z. published an article.Related Products of 6038-19-3 The title of the article was A Direct Xanthate-Based Route to γ-Thiolactones. And the article contained the following:

The first examples of direct synthesis of γ-thiolactones, e.g., I by addition of a thiolactone-based radical are described. Mono- and bis-γ-thiolactones can be obtained by a dilauroyl peroxide initiated addition of thiolactone xanthate to various alkenes such as hex-5-en-2-one, 2-allylmalonate, acrolein diethylacetal, etc. and α,ω-dienes such as 1,7-octadiene and diallyl carbonate. The process is modular and exhibits a high functional group tolerance. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

The Article related to thiolactone preparation diastereoselective, xanthate thiolactone alkene radical addition, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Related Products of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2017, Bernard, L.; Bourdeaux, D.; Pereira, B.; Azaroual, N.; Barthelemy, C.; Breysse, C.; Chennell, P.; Cueff, R.; Dine, T.; Eljezi, T.; Feutry, F.; Genay, S.; Kambia, N.; Lecoeur, M.; Masse, M.; Odou, P.; Radaniel, T.; Simon, N.; Vaccher, C.; Verlhac, C.; Yessad, M.; Decaudin, B.; Sautou, V. published an article.Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods. And the article contained the following:

A wide variety of medical devices (MDs) used in hospitals are made of flexible plasticized polyvinylchloride (PVC). Different plasticizers are present in variable amounts in the PVC matrix of the devices and can leach out into the infused solutions and may enter into contact with the patients. The ARMED1ARMED: Assessment and Risk Management of Medical Devices in Plasticized Polyvinylchloride. project aims to assess the migration of these plasticizers from medical devices and therefore the level of exposure in patients. For the first task of the project, eight methods were developed to directly detect and quantify the plasticizers in the PVC matrix of the MDs. We compared the overall performances of the anal. methods using standardized and validated criteria in order to provide the scientific community with the guidance and the tech. specifications of each method for the intended application. We have shown that routine rapid screening could be performed directly on the MDs using the FTIR technique, with cost-effective analyses. LC techniques may also be used, but with limits and only with individual quantification of the main plasticizers expected in the PVC matrix. GC techniques, especially GC-MS, are both more specific and more sensitive than other techniques. NMR is a robust and specific technique to precisely discriminate all plasticizers in a MD but is limited by its cost and its low ability to detect and quantify plasticizer contamination, e.g. by DEHP. All these results have been confirmed by a real test, called the ” blind test ” carried out on 10 MD samples. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to plasticizer polyvinyl chloride medical device analysis method, analytical methods, comparison, medical devices, plasticizers, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 25, 2016, Bourdeaux, Daniel; Yessaad, Mouloud; Chennell, Philip; Larbre, Virginie; Eljezi, Teuta; Bernard, Lise; Sautou, Valerie published an article.Safety of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Analysis of PVC plasticizers in medical devices and infused solutions by GC-MS. And the article contained the following:

In 2008, di-(2-ethylhexyl) phthalate (DEHP), was categorized as CMR 1B under the CLP regulations and its use in PVC medical devices (MD) was called into question by the European authorities. This resulted in the commercialization of PVC MDs plasticized with the DEHP alternative plasticizers tri-octyl trimellitate (TOTM), di-(2-ethylhexyl) terephthalate (DEHT), di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di-isononyl phthalate (DINP), di-(2-ethylhexy) adipate (DEHA), and Acetyl tri-Bu citrate (ATBC). The data available on the migration of these plasticizers from the MDs are too limited to ensure their safe use. We therefore developed a versatile GC-MS method to identify and quantify both these newly used plasticizers and DEHP in MDs and to assess their migration abilities in simulant solution The use of cubic calibration curves and the optimization of the anal. method by an exptl. plan allowed us to lower the limit of plasticizer quantification. It also allowed wide calibration curves to be established that were adapted to this quantification in MDs during migration tests, irresp. of the amount present, and while maintaining good precision and accuracy. We then tested the developed method on 32 PVC MDs used in our hospital and evaluated the plasticizer release from a PVC MD into a simulant solution during a 24 h migration test. The results showed a predominance of TOTM in PVC MDs accompanied by DEHP (<0.1% weight/weight), DEHT, and sometimes DEHA. The migration tests showed a difference in the migration ability between the plasticizers and a non-linear kinetic release. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Safety of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to polyvinyl chloride plasticizer medical device migration, dehp alternatives, gc–ms, medical devices, migration tests, plasticizers, polyvinyl chloride, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Safety of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 21, 2015, Vlahov, Iontcho R.; Leamon, Christopher P.; Low, Philip S.; Parham, Garth L.; Chen, Qingshou published a patent.Application of 53838-27-0 The title of the patent was Compounds for positron emission tomography. And the patent contained the following:

Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomog. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application of 53838-27-0

The Article related to pet contrast agent conjugate, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Application of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2017, Afroz, Tariq; Hock, Eva-Maria; Ernst, Patrick; Foglieni, Chiara; Jambeau, Melanie; Gilhespy, Larissa A. B.; Laferriere, Florent; Maniecka, Zuzanna; Pluckthun, Andreas; Mittl, Peer; Paganetti, Paolo; Allain, Frederic H. T.; Polymenidou, Magdalini published an article.Synthetic Route of 79642-50-5 The title of the article was Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. And the article contained the following:

TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiol. nuclear TDP-43 in mouse and human brain forms homo-oligomers that are resistant to cellular stress. Physiol. TDP-43 oligomerization is mediated by its N-terminal domain, which can adopt dynamic, solenoid-like structures, as revealed by a 2.1 Å crystal structure in combination with NMR spectroscopy and electron microscopy. These head-to-tail TDP-43 oligomers are unique among known RNA-binding proteins and represent the functional form of the protein in vivo, since their destabilization results in loss of alternative splicing regulation of known neuronal RNA targets. Our findings indicate that N-terminal domain-driven oligomerization spatially separates the adjoining highly aggregation-prone, C-terminal low-complexity domains of consecutive TDP-43 monomers, thereby preventing low-complexity domain inter-mol. interactions and antagonizing the formation of pathol. aggregates. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5

The Article related to tdp43 als rna protein structure brain, General Biochemistry: Proteins and Their Constituents and other aspects.Synthetic Route of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 15, 2008, Riss, Patrick J.; Kroll, Carsten; Nagel, Verena; Roesch, Frank published an article.Formula: C12H15NO4 The title of the article was NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. And the article contained the following:

This report concerns synthesis, 68Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothio-cyanatophenyl-acetic acid (NODAPA-NCS), 1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenyl-acetic acid (NODAPA-(NCS)2) and 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid (NODAPA-OH), versatile bifunctional chelators with potential for mol. imaging. Protein binding and exemplified conjugation are also reported. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4

The Article related to nodapa oh ncs preparation chelator gallium 68 imaging, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Formula: C12H15NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics