Month: November 2022

Qian, Yanzhi; Liu, Fengchao; Zhang, Wenguang; Zheng, Xi; Liao, Shengtao; Lv, Lin; Mei, Zhechuan published an article in 2020, the title of the article was AQP9 suppresses hepatocellular carcinoma cell invasion through inhibition of hypoxia-inducible factor 1α expression under hypoxia.SDS of cas: 2358-84-1 And the article contains the following content:

Background and Aim : Intratumor hypoxia is a hallmark of hepatocellular carcinoma (HCC) and is associated with an aggressive tumor phenotype. Although it has been shown that AQP9 plays an important role in HCC, the relevance between hypoxia and AQP9 is still unknown. Methods : We established in vitro normoxic or hypoxic models to investigate the role of AQP9 in the regulation of hypoxia-inducible factor 1α (HIF-1α) and hypoxia-enhanced invasion of hepatoma cells. Mol. expression was detected using western blot or quant. polymerase chain reaction. Cell invasion ability was determined using Transwell invasion assay. In vivo xenograft experiment was used to detect the role of AQP9 on tumor growth. Results : Our present study revealed a decrease in the expression levels of AQP9 in hypoxic microenvironments. Overexpression of AQP9 led to a decreased expression of HIF-1α; conversely, suppression of AQP9 in HCC cells had an opposite effect. Furthermore, up-regulated AQP9 blocked the hypoxic-enhanced invasion of HCC cells. The overexpression of AQP9 inhibited the growth of tumors and HIF-1α expression in vivo. Conclusions : These data suggest that AQP9 acts as a tumor suppressor in HCC invasion via the regulation of HIF-1α expression in the tumor hypoxic microenvironment. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).SDS of cas: 2358-84-1

The Article related to aqp9 hepatocellular carcinoma cell invasion hif1alpha hypoxia, aquaporin 9, hif-1α, hepatocellular carcinoma, hypoxia, Placeholder for records without volume info and other aspects.SDS of cas: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2022, Lin, Xian; Tao, Cheng; Zhang, Ren; Zhang, Miaomiao; Wang, Qingwen; Chen, Jian published an article.Category: esters-buliding-blocks The title of the article was N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes. And the article contained the following:

Developing alternative targets and drugs for rheumatoid arthritis (RA) treatment is currently an urgent issue. The relationship between TGM2 and the abnormal immune microenvironment in synovium tissues, as well as the specific role of TGM2 in RA are yet to be elucidated. Sarsasapogenin (Sar) is a sapogenin extracted from the Chinese medical herb Anemarrhena asphodeloides Bunge. and served as a representative anti-inflammatory drug capable of ameliorating inflammatory responses in several human diseases. However, the therapeutic effect of Sar on RA remains unknown. This investigation aims to elucidate the role of TGM2 in RA and investigate whether Sar is a candidate drug to target TGM2 of fibroblast-like synoviocytes (FLS). Bioinformatics analyses were applied for elucidating the role of N(6)-methyladenine (m6A) RNA methylation in RA and identifying the specific target regulated by m6A methylation in RA-FLS. Methylated RNA immunoprecipitation, CCK8 assay, Edu assay, flow cytometry, RT-qPCR and Western blot were utilized to investigate the function of Sar and TGM2 in RA-FLS. Bioinformatics analyses emphasized the importance of m6A RNA methylation in RA and identified an m6A methylation-mediated gene TGM2. Interestingly, both m6A RNA methylation and TGM2 expression in RA synovium tissues correlated with activated immuno-inflammatory phenotype and associated with clin. characteristics and therapy response of RA patients. TGM2 served as a promoter of RA-FLS proliferation by inducing DNA replication and cell cycle transition and inhibiting apoptosis through activating NF-κB signaling. Intriguingly, Sar could impair m6A methylation of TGM2 mRNA and downregulate TGM2 expression. Downregulated TGM2 contributed to the suppressive role of Sar in DNA replication and the stimulatory role of Sar in cell cycle arrest and apoptosis of RA-FLS. Mech., Sar inhibited the expression of key regulators in DNA replication, cell cycle, and apoptosis by impairing NF-κB signaling, thus abolishing FLS proliferation to ameliorate RA progression. This cross-validated work based on three independent datasets is detailedly delineated using cell lines and clin. samples, recognizing that TGM2 can be an attractive target and Sar might be a novel anti-RA drug. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Category: esters-buliding-blocks

The Article related to rheumatoid arthritis human sarsasapogenin synoviocytes, n6-methyladenosine, rheumatoid arthritis, sarsasapogenin, tgm2, Placeholder for records without volume info and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2022, Zohmachhuana, Alex; Malsawmdawngliana; Lalnunmawia, F.; Mathipi, Vabeiryureilai; Lalrinzuali, K.; Kumar, N. Senthil published an article.COA of Formula: C13H10O3 The title of the article was Curcuma aeruginosa Roxb. exhibits cytotoxicity in A-549 and HeLa cells by inducing apoptosis through caspase-dependent pathways. And the article contained the following:

The aim of the current study was to examine the efficacy of the leaf, stem and rhizome of Curcuma aeruginosa Roxb. for their phytochem. content, antioxidant and anti-cancer activities. The different parts of C. aeruginosa were subjected to sequential extraction to give three fractions viz., hexane, Et acetate and methanol extract The cytotoxic effect and the mode of action against A-549 human lung adenocarcinoma and HeLa cell lines were examined C. aeruginosa presented no significant toxic effect in normal human lung cells (L-132). The methanol extracts were found to be the most cytotoxic and further investigation was carried out to understand the effects. The methanol extracts induced DNA damage after 24 h with significant increase in tail DNA and tail moment when compared to untreated control. Up-regulation in the expression of the caspase – 8 and – 3 activity was observed after 48 h of treatment. The mechanism of cell death and apoptosis induced by the methanol extracts on A549 and HeLa cells were studied using fluorescent staining. Bioactive compounds detected from the HPLC revealed phenol and flavonoid compounds: Gallic acid, quercetin, caffeic acid, kaempferol, rutin, coumaric acid and naringenin. GC-MS results identified the presence of sesquiterpenoids: alpha-curcumene, curzerene curcumenol, curzerenone epicurzerenone, caryophyllene oxide and diterpenoid, andrographolide. These compounds are known for inducing apoptosis in human cancer cells through caspase – dependent pathways. Therefore, C. aeruginosa and its potential to induce apoptosis in cancer cells suggest that they have potential in medical applications. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).COA of Formula: C13H10O3

The Article related to curcuma aeruginosa a549 hela cell apoptosis cytotoxicity caspase pathway, antioxidant, apoptosis, caspase, comet assay, mtt, Placeholder for records without volume info and other aspects.COA of Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 10, 2021, Li, Wen-Long; Zhang, Zi-Feng; Li, Yi-Fan; Hung, Hayley; Yuan, Yi-Xing published an article.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Assessing the distributions and fate of household and personal care chemicals (HPCCs) in the Songhua Catchment, Northeast China. And the article contained the following:

Many household and personal care chems. (HPCCs) are of environmental concern due to their potential toxicity to humans and wildlife. However, few studies investigate the spatiotemporal variations and fate of HPCCs in large-scale river systems. Here, river water and sediment samples from the Songhua River in Northeast China were analyzed for seven classes of HPCCs. Correlation anal. suggested similar sources and environmental behavior for compounds from the same HPCC classes. In the river water, the concentrations of most HPCCs in the cold season were significantly higher than that of the warm season (p < 0.01). Significantly higher levels of target compounds were found in the downstream water samples of a city, suggesting the influence of human activities on the distributions of HPCCs. The concentrations and distributions of most HPCCs were controlled by primary emission sources. The derived dissolved concentrations of HPCCs suggested that small amounts of caffeine and parabens were partitioned onto particles, while large amounts of many other HPCCs were bound to the particle phase. Water-sediment distribution coefficients (log Kd) ranged from 1.59 for caffeine to 3.95 for benzalkonium chloride-C14. This work presents new insights into the environmental behavior of HPCCs and the factors affecting their fate in river systems. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to household personal care chem river water surface sediment, household personal care, river, sediments, solid-liquid partitioning, Placeholder for records without volume info and other aspects.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2021, Dimitriadi, M.; Petropoulou, A.; Anagnostou, M.; Zafiropoulou, M.; Zinelis, S.; Eliades, G. published an article.Electric Literature of 1985-51-9 The title of the article was Effect of curing mode on the conversion and IIT-derived mechanical properties of core build-up resin composites. And the article contained the following:

The aim of the study was to evaluate the degree of conversion and the mech. properties of five composite core build-up materials polymerized in dual-curing and self-curing modes. The materials tested were: Clearfil DC Core Plus (CF), Gradia Core (GC), Luxacore-Z Dual Smartmix (LX), Multicore Flow (MC) and Paracore (PC). Disk-shaped specimens were prepared from each material; half the specimens were light-cured, whereas the rest were only self-cured. After a 3-wk storage period (dark/dry/37 °C) the Martens Hardness, Indentation Modulus, and Elastic Index were determined by instrumented indentation testing (IIT), while the degree of conversion was assessed by ATR-FTIR spectroscopy. Statistical anal. was performed by 2-way ANOVA and post-hoc testing (α = 0.05). The dual-curing mode resulted in statistically higher Martens Hardness and Elastic Index than the self-curing mode in most materials but showed insignificant differences in Indentation Modulus. MC and PC demonstrated significantly higher degree of conversion in both curing modes. Overall, the self-curing mode was inferior to the dual-curing in conversion and mech. properties for most products, despite their differences in monomer composition and filler loading. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Electric Literature of 1985-51-9

The Article related to core buildup resin composite curing monomer compound, atr-ftir, conversion, core build-up composites, iit, mechanical properties, Placeholder for records without volume info and other aspects.Electric Literature of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tabaszewska, Malgorzata; Najgebauer-Lejko, Dorota; Zbylut-Gorska, Maria published an article in 2022, the title of the article was The Effect of Crataegus Fruit Pre-Treatment and Preservation Methods on the Extractability of Aroma Compounds during Liqueur Production.HPLC of Formula: 123-25-1 And the article contains the following content:

The leaves, inflorescences, and fruits of hawthorn have long been known for their therapeutic properties. A wide range of hawthorn products, including liqueurs, are manufactured, due to the technol. potential of the raw material as well as the richness of its volatile compounds This study aimed to determine the effect of the liqueur production method and various methods of fruit preservation on the quant. and qual. composition of volatile compounds in the liqueurs produced. Hawthorn fruits saturated with sucrose and non-saturated with sucrose, fresh or preserved through one of three methods: freezing, air-drying, and freeze-drying, were used for liqueur preparation The samples were analyzed using a gas chromatograph-mass spectrometer. They were found to contain 54 volatile compounds classified into 12 groups of chems. All 54 identified volatile compounds were detected in the liqueur made from hawthorn fruits non-saturated with sucrose and preserved by freeze-drying. In this liqueur type, 12 of the identified volatile compounds occurred in the highest concentration when compared to the other treatments. Among all volatiles, the following compounds were present in the analyzed liqueurs in the highest concentrations: dodecanoic acid Et ester (11.782 g/100 g), lactones (6.954 g/100 g), five monoterpenes (3.18 g/100 g), two aromatic hydrocarbons (1.293 g/100 g), isobensofuran (0.67 g/100 g), alc.-2-methyl-2-propanol (0.059 g/100 g), and malonic ester (0.055 g/100 g). Among all analyzed liqueurs, the one made from the fruits non-saturated with sucrose and frozen was characterized by the smallest diversity of volatiles, which were present in the lowest concentrations in that liqueur. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).HPLC of Formula: 123-25-1

The Article related to crataegus fruit preservation method extractability aroma compound liqueur production, pca, hawthorn, liqueur, volatile compounds, Placeholder for records without volume info and other aspects.HPLC of Formula: 123-25-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Satoka; Abe, Arisa; Ishikawa, Naoto; Rafique, Abdur; Ito, Yuji published an article in 2021, the title of the article was A novel site-specific chemical conjugation of IgG antibodies by affinity peptide for immunoassays.HPLC of Formula: 79642-50-5 And the article contains the following content:

Recently, there has been an increasing interest in site-specific modifications of antibodies used in immunoassays for disease diagnosis and as antibody therapeutics, such as antibody-drug conjugates. Previously, we established a site-specific chem. conjugation system using an IgG-Fc binding chem. conjugation affinity peptide (CCAP). CCAP could be used only for the modification of human IgG owing to the lack of affinity of CCAP to rodent IgG mols. In this study, novel CCAP reagents are proposed, which can be used for both human and mouse IgG, based on the Staphylococcus aureus protein A domain-derived affinity peptides Z34C and Z33. Compared with the activity of a conventional randomly modified antibody, mouse IgG modified using this method had favorable features in two immunoassays, demonstrating the advantages of the proposed CCAP method in preserving antibody functionality during conjugation. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).HPLC of Formula: 79642-50-5

The Article related to staphylococcus aureus igg monoclonal antibodies peptide immunoassay, rpla, antibody, conjugation, immunoassay, peptide, protein a, Placeholder for records without volume info and other aspects.HPLC of Formula: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2021, Beiras, Ricardo published an article.Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Towards standard methods for the classification of aquatic toxicity for biologically active household chemicals (BAHC) present in plastics, pharmaceuticals, and cosmetic products. And the article contained the following:

A standard method to test the aquatic toxicity of biol. active household chems. (BAHC), including those with very low water solubility, is proposed. The method uses the common marine models Paracentrotus lividus embryos and Acartia clausi larvae, in order to advance towards derivation of water quality criteria for these emerging pollutants that currently lack environmental standards Depending on the water solubility and octanol-water partition coefficient (Kow) of the substance, the protocol consists of testing the toxicity of the substances by serial dilutions of water stocks, dimethyl-sulfoxide stocks, or 100 mg/L lixiviates in seawater. When this method is applied to eleven model BAHC, the pharmaceutical fluoxetine, the antioxidant butylated hydroxytoluene, and the UV filters broadly present in cosmetics octocrylene and 4-methylbenzylidene camphor, are classified as very toxic to aquatic life, since their EC50 values are < 1 mg/L. In general, both biol. models, P. lividus and A. clausi, yield the same classification of the substances tested, but variations in the classification of aquatic toxicity depending on methodol. aspects are discussed. The use of A. clausi nauplii provides more protecting value to the toxicity parameters obtained by using this protocol. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to aquatic toxicity bahc plastic pharmaceutical cosmetic product, copepods, echinoderms, larvae, toxicity, uv filters, water quality, Placeholder for records without volume info and other aspects.Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phelan-Dickinson, Sarah J.; Palmer, Brian C.; Chen, Yue; DeLouise, Lisa A. published an article in 2020, the title of the article was The UVR filter octinoxate modulates aryl hydrocarbon receptor signaling in keratinocytes via inhibition of CYP1A1 and CYP1B1.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate And the article contains the following content:

UV radiation (UVR) is a consistent part of the environment that has both beneficial and harmful effects on human health. UVR filters in the form of com. sunscreens have been widely used to reduce the neg. health effects of UVR exposure. Despite their benefit, literature suggests that some filters can penetrate skin and have off-target biol. effects. We noted that many organic filters are hydrophobic and contain aromatic rings, making them potential modulators of Aryl hydrocarbon Receptor (AhR) signaling. We hypothesized that some filters may be able to act as agonists or antagonists on the AhR. Using a luciferase reporter cell line, we observed that the UVR filter octinoxate potentiated the ability of the known AhR ligand, 6-formylindolo[3,2-b]carbazole (FICZ), to activate the AhR. Cotreatments of keratinocytes with octinoxate and FICZ lead to increased levels of cytochrome P 4501A1 (CYP1A1) and P 4501B1 (CYP1B1) mRNA transcripts, in an AhR-dependent fashion. Mechanistic studies revealed that octinoxate is an inhibitor of CYP1A1 and CYP1B1, with IC50 values at approx. 1 μM and 586 nM, resp. In vivo topical application of octinoxate and FICZ also elevated CYP1A1 and CYP1B1 mRNA levels in mouse skin. Our results show that octinoxate is able to indirectly modulate AhR signaling by inhibiting CYP1A1 and CYP1B1 enzyme function, which may have important downstream consequences for the metabolism of various compounds and skin integrity. It is important to continue studying the off-target effects of octinoxate and other UVR filters, because they are used on skin on a daily basis world-wide. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to octinoxate aryl hydrocarbon receptor cyp1a1 cyp1b1 keratinocyte, cyp1a1, cyp1b1, aryl hydrocarbon receptor, octinoxate, sunscreens, Placeholder for records without volume info and other aspects.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sheikh, Ishfaq A.; Yasir, Muhammad; Abu-Elmagd, Muhammad; Dar, Tanveer A.; Abuzenadah, Adel M.; Damanhouri, Ghazi A.; Al-Qahtani, Mohammed; Beg, Mohd. A. published an article in 2016, the title of the article was Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study.Computed Properties of 3319-31-1 And the article contains the following content:

Current information regarding the safety and potential adverse effects of alternate plasticizers is limited and recent studies have found alternate plasticizers to display similar characteristics to those observed in phthalate plasticizers. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly used alternate plasticizers: di(2-ethylhexyl)terephthalate (DEHT), tris(2-ethylhexyl) trimellitate (TOTM), and diisononyl hexahydrophthalate (DINCH) against human sex hormone-binding globulin (SHBG) using in silico approaches. Materials and methods: The crystal structure of human SHBG (Id: 1D2S) was retrieved from Protein Data Bank. Results: Induced Fit Docking of three alternate plasticizer compounds indicated that each of the three compounds fitted well into the steroid binding pocket of SHBG. Docking displays showed interactions of alternate plasticizers with 25-30 amino-acid residues of SHBG; 18-20 amino residues overlapped between the natural ligand, DHT, and the three compounds (commonality of 82-91 %). The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates. Conclusion: Our results suggested that the three alternate plasticizers have potential to engage the important interacting residues of SHBG and thus interfere in its steroid homeostatic function. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Computed Properties of 3319-31-1

The Article related to sex hormone binding globulin mol docking plasticizer, deht, dinch, docking, endocrine disruption, sex hormone-binding globulin, totm, Placeholder for records without volume info and other aspects.Computed Properties of 3319-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics