Month: November 2022

Ucar, Guenes published the artcileVolatile needle and wood extracts of oriental spruce Picea orientalis (L.) Link, COA of Formula: C12H14O2, the publication is Flavour and Fragrance Journal (2003), 18(5), 368-375, database is CAplus.

Volatile needle and wood extracts of oriental spruce obtained from trees grown naturally in eastern Black Sea regions and in an cultivated stand near Istanbul were analyzed by GC-MS. Despite considerable differences in both tree-to-tree and natural-to-cultivated aspects, the needle and wood extracts exhibit characteristic compounds, which might be of chemotaxonomic interest. The monoterpenes δ-3-carene, limonene and bornyl acetate dominate in the needles, whereas the appreciable amounts of labdadienol isomers and high content of diterpenoids characterize the wood extracts

Flavour and Fragrance Journal published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C10H15NO, COA of Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bally, Ioana published the artcileSynthesis of carbon-14-labeled isotope-isomeric alkanes. II. Preparation of 2,2,4-trimethylpentane-14C2 labeled at both methyl groups of the isopropyl moiety, Recommanded Product: Ethyltert-butylacetate, the publication is Revue Roumaine de Chimie (1975), 20(11-12), 1471-2, database is CAplus.

Me3CCH2CH(14CH3)2 was prepared in 5 steps from H2C:CCl2 via treatment with Me3COH, and H2O to give Me3CCH2CO2H, which was successively esterified and treated with 14CH3I to give Me3CCH2C(14CH3)2OH:14CH2 and Me3CCH:C(14CH3)2, which were hydrogenated.

Revue Roumaine de Chimie published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Recommanded Product: Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rabizadeh, E. published the artcileDoxorubicin and a butyric acid derivative effectively reduce levels of bcl-2 protein in the cells of chronic lymphocytic leukemia patient, Safety of (Pivaloyloxy)methyl butyrate, the publication is European Journal of Haematology (2001), 66(4), 263-271, database is CAplus and MEDLINE.

B-chronic lymphocytic leukemia (B-CLL) is a disease caused primarily by defects in the apoptosis mechanism. AN-9, a butyric acid (BA) derivative, is a potent differentiating and an anti-cancer drug that induces apoptosis in HL-60 cells. Herein the authors show the effect of AN-9, alone and in combination with doxorubicin, on cell cultures from B-CLL patients. Cells from 17 patients were cultured and tested for viability, apoptosis, bcl-2, and Bax protein expression. Exposure of B-CLL cell cultures to AN-9 was accompanied by apoptosis and a marked viability loss (up to 46%, p=0.0017). AN-9 reduced up to 51% (p=0.0017) the levels of bcl-2 in 57% of the cultures that express bcl-2. The combination of low concentrations of AN-9 and doxorubicin more than additively enhanced apoptosis and reduced bcl-2 levels in B-CLL cultures which were resistant to AN-9. AN-9 enhanced Bax expression up to 58% (p=0.008) in cultures from 53% of the patients but had no effect on Bax levels when combined with doxorubicin. In conclusion, AN-9 alone reduced bcl-2 and enhanced Bax expression in cultures from B-CLL patients, and the reduction of bcl-2 levels in combination with doxorubicin was greater than additive. These results may be beneficial in possible future combination therapy with AN-9 in B-CLL.

European Journal of Haematology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Safety of (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Murray, Stephen published the artcileDirect derivatization of sulfate esters for analysis by gas chromatography mass spectrometry, Synthetic Route of 6217-68-1, the publication is Biomedical Mass Spectrometry (1979), 6(2), 82-9, database is CAplus.

Gas chromatog.-mass spectrometry was used to study the reaction between 13 aromatic, steroidal and aliphatic sulfate esters and 3 perfluoroacylating reagents, viz. (CF₃CO)₂O, (C₂F₅CO)₂O and (CF₃CF₂CF₂CO)₂O. Aromatic sulfates reacted readily with 1:1 anhydride:AcOEt to give the perfluoro ester of the parent phenol quant. Nonaromatic sulfates gave a variety of products. A mechanism is proposed for the 1-step derivatization of aromatic sulfates, and the potential of the procedure for the anal. of sulfate conjugates by mass spectrometry is discussed.

Biomedical Mass Spectrometry published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Synthetic Route of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Humphries, Paul S. published the artcilePyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents, Synthetic Route of 5340-78-3, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(23), 6120-6123, database is CAplus and MEDLINE.

A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, I [R,R¹ = CH₂CH₂; R = R¹ = Me] were selected for further profiling.

Bioorganic & Medicinal Chemistry Letters published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Synthetic Route of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hua, Daoben published the artcileDithiocarbamate mediated controlled/living free radical polymerization of methyl acrylate under ⁶⁰Co γ-ray irradiation: Conjugation effect of N-group, Synthetic Route of 3052-61-7, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2004), 42(22), 5670-5677, database is CAplus.

The free radical polymerizations of Me acrylate have been studied under γ-ray irradiation in the presence of the dithiocarbamates with different N-groups. The results indicate that the conjugation structure of the N-group of dithiocarbamate plays an important role in living free radical polymerization The polymerizations reveal good living characteristics in the presence of dithiocarbamates (benzyl 1H-imidazole-1-carbodithioate, benzyl 1H-pyrrole-1-carbodithioate, benzyl 1H-indole-1-carbodithioate, and benzyl 9H-carbazole-9-carbodithioate) with N-aryl group. In contrast, the polymerization with benzyl N,N-diethyldithiocarbamate cannot be controlled, and the obtained polymer has a broad mol. weight distribution or even crosslink occurs. Moreover, polymerization rate is influenced by the conjugation structure of the N-group of dithiocarbamate, and the aromatic polycyclic structure of the N-group leads to slow polymerization

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Synthetic Route of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bosch, Joan published the artcileStereoselective Syntheses of the Antihistaminic Drug Olopatadine and Its E-Isomer, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Journal of Organic Chemistry (2012), 77(14), 6340-6344, database is CAplus and MEDLINE.

Practical stereoselective synthetic routes to the antihistaminic drug olopatadine (I) and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.

Journal of Organic Chemistry published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Noji, Masahiro published the artcileProton-accelerated Lewis acid catalysis for stereo- and regioselective isomerization of epoxides to allylic alcohols, Recommanded Product: 3-Methylbut-2-en-1-yl benzoate, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(58), 7104-7107, database is CAplus and MEDLINE.

The isomerization of epoxides to allylic alcs. was developed via proton-accelerated Lewis acid catalysis. The addition of tBuOH as a proton source was the key to the efficient catalytic cycle. Trisubstituted epoxides, including enantioenriched derivatives, were selectively converted to secondary-allylic alcs. without loss of enantiopurity.

Chemical Communications (Cambridge, United Kingdom) published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Recommanded Product: 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vekey, Karoly published the artcileIdentification of Z and E isomers by chemical ionization, Safety of (Z)-Dodec-9-en-1-yl acetate, the publication is Biomedical & Environmental Mass Spectrometry (1988), 16(1-12), 267-8, database is CAplus.

A method is described for differentiation between the Z and E isomers of long-chain monounsaturated acetates without the need for chem. derivatization and special instrumentation. Chem.-ionization spectra were recorded on a VG MM-12 single-focusing mass spectrometer using a combined electron-impact/chem.-ionization source. Samples were introduced via a gas chromatograph using a glass column packed with SE-30 stationary phase. The model compounds were (Z)-Me(CH₂)_nCH:CH(CH₂)_mOAc (n = 1 or 3, m = 4, 8, or 10) and its E isomer.

Biomedical & Environmental Mass Spectrometry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C9H12O, Safety of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bampidis, Vasileios published the artcileSafety and efficacy of a feed additive consisting of an essential oil from the flowers of Cananga odorata (Lam.) Hook.f. & Thomson (ylang ylang oil) for use in all animal species (FEFANA asbl), Quality Control of 5205-11-8, the publication is EFSA Journal (2022), 20(2), e07159, database is CAplus and MEDLINE.

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of an essential oil from the flowers of Cananga odorata (Lam.) Hook.f. & Thomson (ylang ylang oil), when used as a sensory additive in feed and water for drinking for all animal species. The FEEDAP Panel concluded that the essential oil under assessment is safe up to the maximum proposed use levels in complete feed of 1 mg/kg for chickens for fattening, 1.5 mg/kg for laying hens, turkeys for fattening and rabbits, 2 mg/kg for piglets, 2.5 mg/kg for pigs for fattening, 3 mg/kg for sows, 4.5 mg/kg for cattle for fattening, sheep, goats and horses, 5 mg/kg for veal calves (milk replacer), fish, dogs and ornamental fish. For cats, the calculated safe concentration in complete feed is 1 mg/kg feed. The FEEDAP Panel considered that the use in water for drinking is safe provided that the total daily intake of the additive does not exceed the daily amount that is considered safe when consumed via feed. No concerns for consumer safety were identified following the use of the additive up to the maximum proposed use level in feed. The essential oil under assessment should be considered as irritant to skin and eyes, and as a skin and respiratory sensitizer. The use of the additive in animal feed under the proposed conditions of use was not expected to pose a risk for the environment. Ylang ylang oil is recognized to flavor food. Since its function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary.

EFSA Journal published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Quality Control of 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics