Month: November 2022

Cardoso, Ruthinea Faria de Moraes published the artcilePhysicochemical characterization, water sorption and solubility of adhesive systems incorporated with titanium tetrafluoride, and its influence on dentin permeability, Formula: C11H15NO2, the publication is Journal of the Mechanical Behavior of Biomedical Materials (2021), 104453, database is CAplus and MEDLINE.

Titanium tetrafluoride (TiF4) in an aqueous solution can decrease dentin permeability, but some effects of its incorporation into adhesive systems are not yet known. Therefore, the aim of this study was to characterize the physicochem., water sorption (WS) and solubility (SL) properties of two adhesive systems (Clearfil SE Bond/C and Scotchbond Universal/S) incorporated with 0.0% (T0), 2.5% (T2) and 4.0% (T4) titanium tetrafluoride (TiF4), and determine dentin permeability (L) after application of these adhesive systems both immediately afterwards (baseline) and after 6 mo of storage. The physicochem. analyses of the incorporated solutions were performed based on evaluating particle size (PS), polydispersity index (PDI) by dynamic light scattering, and zeta potential (ZP) by electrophoresis. WS and SL tests followed ISO 4049 standards, and used a 7-day water storage period. The L test was performed by analyzing human dentin disks before and after adhesive system application, and after storage. PS and PDI were higher for CT0 and ST4 (p < 0.0001; ANOVA, Tukey). ZP was lower for CT4, ST2 and ST4 (p < 0.0001; ANOVA, Tukey). A 4.0% TiF4 incorporation showed higher WS (p < 0.05; Mann Whitney, Kruskal Wallis, Dunn). Higher SL was observed for CT0 and ST4 (p < 0.05; Mann Whitney, Kruskal Wallis, Dunn). The L value at baseline was lower for ST4, but was not different from the CT4 groups after storage (p < 0.05; Mann Whitney, Kruskal Wallis, Dunn). It can be concluded that TiF4 affected the colloidal stability of Scotchbond, but did not alter the other properties. The 2.5% TiF4 did not affect the PDI, WS or L of the Clearfil, and can be considered an alternative for reducing hybrid layer degradation

Journal of the Mechanical Behavior of Biomedical Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Formula: C11H15NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shaw, Charles J. published the artcileA direct HPLC method for the resolution of glycidyl tosylate and glycidyl 3-nitrobenzenesulfonate enantiomers, Quality Control of 115314-17-5, the publication is Journal of Pharmaceutical and Biomedical Analysis (1991), 9(10-12), 793-6, database is CAplus and MEDLINE.

The enantiomeric composition of glycidyl tosylate and glycidyl 3-nitrobenzenesulfonate is obtained using an enantiomeric HPLC column. The chiral oxiranes were resolved on a cellulose carbamate column using a mobile phase of hexane/2-propanol. The method is simple, sensitive, and does not require derivatization.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C7H8INO, Quality Control of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fusini, Graziano published the artcileIdentification and synthesis of new sex-specific components of olive fruit fly (Bactrocera oleae) female rectal gland, through original Negishi reactions on supported catalysts, Formula: C20H40O2, the publication is Tetrahedron (2018), 74(33), 4381-4389, database is CAplus.

In the present study, eleven new sex-specific components extracted from female rectal gland of olive fruit flies were synthesized and identified. The quant. determination of those components by GC and GC/EI-MS, at different moments of the insect life span, highlighted the growing trend of their secretion. While for the synthesis of saturated esters, conventional transesterification methods could be adopted, for the synthesis of unsaturated components, a Negishi cross-coupling between organozinc halides and (Z)-1-bromo-1-alkenes was developed. To the extent of our knowledge, this reaction represents the first example of supported-catalyst promoted Negishi coupling, between an alkylzinc reagent and an alkenyl halide.

Tetrahedron published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Formula: C20H40O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Garcia Ruano, Jose L. published the artcileHighly Stereoselective Aldol Reactions of Lithium Ester Enolates with (R_S)-2-(p-Tolylsulfinyl)cyclohexanones, Application In Synthesis of 5340-78-3, the publication is Journal of Organic Chemistry (1996), 61(26), 9462-9470, database is CAplus.

Aldol reactions of lithium alkyl acetates (LiCRR”CO₂R’) with (R_S)-2-(p-tolylsulfinyl)cyclohexanone (1) (as an epimeric mixture at C-2) take place with very efficient control of the configuration at the tertiary hydroxylic carbon (C-1). Stereoselectivity becomes complete if R and/or R” are not hydrogen. Only carbinols derived from the (S₂,R_S)-1 epimer were obtained, the major ones being those exhibiting the S configuration (opposite to that of the sulfur) at the hydroxylic carbon. When LiCHRCO₂R’ is used, mixtures of the two epimers at the new stereogenic center C-1′ are obtained (∼10-82% de), their proportion being dependent on the size of R. The use of lactone enolates avoids the formation of epimeric mixtures, affording only one diastereoisomer with an (R_3′,S₁,S₂,R_S) configuration at the four adjacent chiral centers. Tricoordinated lithium species, which involve the enolate and the sulfinyl and carbonyl oxygens of the substrates, are invoked to explain the stereoselectivity observed in these aldol reactions with sulfinyl ketones as electrophiles.

Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Loudet, J. C. published the artcileColloidal Structures from Bulk Demixing in Liquid Crystals, COA of Formula: C15H14O3, the publication is Langmuir (2004), 20(26), 11336-11347, database is CAplus and MEDLINE.

This exptl. paper deals with phase separations of binary mixtures composed of a continuous liquid crystal phase and an isotropic dispersed phase. In contrast to isotropic binary mixtures, the studied mixtures do not lead to a full phase separation but to a self-ordering of colloidal particles, as reported earlier (Loudet, J. C. et al., Nature 2000, 407, 611). The authors present here further aspects of such phase separations which include the kinetics of the phase separation, the origin of the formation of dislocation-like patterns, the influence of surfactants, chiral additives, and temperature on the formed colloidal structures. (i) The dislocations in chain arrays can be seen as kinetically frozen defects, (ii) temperature can be used to control the size of the domains formed upon demixing, (iii) a slight change in surface chem., via the addition of surfactants, profoundly alters the formed colloidal structures, and (iv) chiral additives gave unique helical pearl chains which reflect the symmetry of the liquid crystal phase they are embedded in.

Langmuir published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, COA of Formula: C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Winter-Holt, Jon J. published the artcileDiscovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2022), 65(4), 3306-3331, database is CAplus and MEDLINE.

ATAD2 is an epigenetic bromodomain-containing target which is overexpressed in many cancers and has been suggested as a potential oncol. target. While several small mol. inhibitors have been described in the literature, their cellular activity has proved to be underwhelming. In this work, we describe the identification of a novel series of ATAD2 inhibitors by high throughput screening, confirmation of the bromodomain region as the site of action, and the optimization campaign undertaken to improve the potency, selectivity, and permeability of the initial hit. The result is compound 5 (AZ13824374)(I), a highly potent and selective ATAD2 inhibitor which shows cellular target engagement and antiproliferative activity in a range of breast cancer models.

Journal of Medicinal Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C8H5F3O2S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Alexeev, K. S. published the artcileCorrelation of fire hazard characteristics with chemical structure. V. Carboxylic acids, Related Products of esters-buliding-blocks, the publication is Pozharovzryvobezopasnost (2012), 21(7), 35-46, database is CAplus.

There are found the empirical formulas for prediction of chem., phys. and fire hazard characteristics for aliphatic carboxylic acids. There are shown application of the hydrocarbon chain rule and the effect of the functional group for forecast of fire hazard characteristics on an example of aliphatic carboxylic acids.

Pozharovzryvobezopasnost published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Platts, Michelle Y. published the artcileA concise synthesis of HIV integrase inhibitors bearing the dipyridone acid motif, Formula: C7H13NO2, the publication is Tetrahedron Letters (2011), 52(4), 512-514, database is CAplus.

An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ deprotection to afford the title compounds

Tetrahedron Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Faya, V. published the artcileS_C^* and S_C̃^_* phases in chiral non-symmetric dimesogens, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Liquid Crystals (1996), 21(4), 485-503, database is CAplus.

The authors synthesized two sep. homologous series of chiral nonsym. dimesogens: these have a two Ph ring moiety bearing a terminal alkoxy chain linked via a methylenic spacer to a chiral three Ph ring mesogen which itself displays antiferroelec. properties. Depending on the parity of the number of carbons constituting the spacer, two kinds of mesomorphic behavior were found. When the spacer is even, various S_C^* phases (S_C^*A,S_C^*FI,S_C^*,S_C^*α) were identified without doubt, whereas when the spacer is odd, a tilted modulated phase (S_C̃^*) was observed and characterized. In each case, the authors study the effect of the length of the alkoxy chain at the end of the shorter moiety. The alternation of the mesomorphic behavior with the spacer parity was interpreted in terms of mol. shape, but the authors have also discussed the influence of some chem. parameters on the stability of the S_C^*A phase.

Liquid Crystals published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tomasic, Tihomir published the artcileDesign, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors, Application of 3-(Methoxycarbonyl)benzoic acid, the publication is Archiv der Pharmazie (Weinheim, Germany) (2018), 351(1), n/a, database is CAplus and MEDLINE.

Discovery of novel DNA gyrase B inhibitors remains an attractive field in the search for new antibacterial drugs to overcome the known bacterial resistance mechanisms. In the present study, we designed and synthesized novel ethylurea derivatives of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine, 2-(2-aminothiazol-4-yl)acetic acid, and benzo[1,2-d]thiazole-2,6-diamine and evaluated their Escherichia coli DNA gyrase inhibition. The most potent DNA gyrase inhibitors in the prepared library of compounds were benzo[1,2-d]thiazoles with IC₅₀ values in the low micromolar range. The most promising inhibitors identified were evaluated against selected Gram-pos. and Gram-neg. bacterial strains. Compound I showed a MIC of 50 μM against an E. coli efflux pump-defective strain, which suggests that efflux decreases the on-target concentrations of these compounds

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H13NO2, Application of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics