Waring, Paul published the artcileThe dihydropteridine reductase (human brain) [substrate] activity of some lipophilic quinonoid dihydropterins, COA of Formula: C8H16O2, the publication is European Journal of Medicinal Chemistry (1987), 22(2), 83-90, database is CAplus.
I [R1 = Et, Pr, Me(CH2)5, PhCH2CH2, and neopentyl; R2 = H] and I (R1 = H, R2 = neopentyl) were prepared by reduction of the corresponding II with PtO2. Oxidation of I‘s gave the corresponding III which were good substrates for dihydropteridine reductase from human brain when compared with the natural cofactor quinonoid dihydrobiopterin III [R1 = 6R (1R,2′S)-1′,2′-dihydroisopropyl, R2 = H), III (R1 = Me, R2 = H), III (R1 = H, R2 = Me) and quinonoid dihydrofolic acid III (R1 = p-methylaminobenzoylglutamic acid, R2 = H). In contrast 5-(2-propylimino) and 5-(2-octylimino)-2,4-diaminopyrimidin-6(1H)-ones were devoid of substrate or inhibitor activities. The potential use of these lipophilic pterins in the therapy of diseases where there is a deficiency of tetrahydrobiopterin is discussed.
European Journal of Medicinal Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H14O2, COA of Formula: C8H16O2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics