Enhancement of atazanavir solubility using β-cyclodextrin based nanosponges was written by Venkatesh, D. N.. And the article was included in Special Publication – Royal Society of Chemistry in 2020.Product Details of 102-09-0 The following contents are mentioned in the article:
Cyclodextrins are capable in forming inclusion complexation with various mols. resulting in increased solubility of drugs. Recently nanosponges have gained considerable attention, owing to their biocompatibility, nanoporous in nature, capable of forming supra mol. inclusion complexes with both hydrophilic and lipophilic drugs. Nanosponges are nanostructured carriers prepared by reacting cyclodextrin with suitable cross linkers such as carbonyl diimidazole, hexamethylene and di-Ph carbonate. In the present study, Atazanavir (ATZ) was selected as it is BCS Il drug having low solubility (0.11 mg/I) with a log P value of 5.6.4. It is used in the treatment of Human Immunodeficiency Virus (HIV) infection with better potency, but low oral bioavailability. Atazanavir-β-cyclodextrin based nanosponges were prepared with varying concentration of 1,1 carbonyl diimidazole (CDI) as cross linker. The prepared nanosponges were characterized for FTIR spectroscopy study, SEM and in vitro dissolution study. A remarkable increase in the solubility and dissolution rate was observed However, in vivo studies are required to establish the potential effect of this formulation is necessary. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Product Details of 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics