Evaluation of EDTA Dianhydride Versus Diphenyl Carbonate Nanosponges for Curcumin was written by Mashaqbeh, Hadeia;Obaidat, Rana;Al-shar’i, Nizar A.. And the article was included in AAPS PharmSciTech in 2022.SDS of cas: 102-09-0 The following contents are mentioned in the article:
Cyclodextrin-based nanosponges are widely investigated for several applications and are considered potential drug carriers. The method of nanosponges preparation involves the use of chem. crosslinking agents where the properties of Nanosponges can be affected. This study compared the resulting differences in the final nanosponges’ properties using carbonate and dianhydride crosslinkers. Di-Ph carbonate and EDTA dianhydride were used for the synthesis of nanosponges. Both types of nanosponges were loaded with curcumin as a model drug. Physicochem. characterizations, including PXRD, DSC, FTIR, SEM, AFM, particle size, zeta potential, and surface area anal., were carried out for the prepared nanosponges. Curcumin release and drug content were also evaluated. Nanosponges prepared by Di-Ph carbonate crosslinker resulted in an amorphous form compared to crystalline EDTA-nanosponges. This study reported the successful inclusion and complexation of curcumin inside carbonate cross-linked cyclodextrin-based nanosponges and suggested the phys. entrapment of crystalline curcumin in EDTA dianhydride. These findings were further investigated and supported by computational modeling. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0SDS of cas: 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics