Lakshmi, Dhana published the artcileElectrochemical Sensor for Catechol and Dopamine Based on a Catalytic Molecularly Imprinted Polymer-Conducting Polymer Hybrid Recognition Element, Recommanded Product: Benzyl diethylcarbamodithioate, the publication is Analytical Chemistry (Washington, DC, United States) (2009), 81(9), 3576-3584, database is CAplus and MEDLINE.
One of the difficulties with using molecularly imprinted polymers (MIPs) and other elec. insulating materials as the recognition element in electrochem. sensors is the lack of a direct path for the conduction of electrons from the active sites to the electrode. The authors have sought to address this problem through the preparation and characterization of novel hybrid materials combining a catalytic MIP, capable of oxidizing the template, catechol, with an elec. conducting polymer. In this way a network of “mol. wires” assists in the conduction of electrons from the active sites within the MIP to the electrode surface. This was made possible by the design of a new monomer that combines orthogonal polymerizable functionality; comprising an aniline group and a methacrylamide. Conducting films were prepared on the surface of electrodes (Au on glass) by electropolymerization of the aniline moiety. A layer of MIP was photochem. grafted over the polyaniline, via N,N’-diethyldithiocarbamic acid benzyl ester (iniferter) activation of the methacrylamide groups. Detection of catechol by the hybrid-MIP sensor was specific, and catechol oxidation was detected by cyclic voltammetry at the optimized operating conditions: potential range -0.6 V to +0.8 V (vs. Ag/AgCl), scan rate 50 mV/s, PBS pH 7.4. The calibration curve for catechol was linear to 144 μM, with a limit of detection of 228 nM. Catechol and dopamine were detected by the sensor, whereas analogs and potentially interfering compounds, including phenol, resorcinol, hydroquinone, serotonin, and ascorbic acid, had minimal effect (≤3%) on the detection of either analyte. Non-imprinted hybrid electrodes and bare gold electrodes failed to give any response to catechol at concentrations below 0.5 mM. Finally, the catalytic properties of the sensor were characterized by chronoamperometry and were consistent with Michaelis-Menten kinetics.
Analytical Chemistry (Washington, DC, United States) published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Recommanded Product: Benzyl diethylcarbamodithioate.
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