Synthesis, characterization and investigation of the antioxidant activity of some 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthiourea moieties was written by Harrouche, Kamel;Lahouel, Asma;Belghobsi, Mebrouk;Pirotte, Bernard;Khelili, Smail. And the article was included in Canadian Journal of Chemistry in 2019.Computed Properties of C4H7NS The following contents are mentioned in the article:
A series of 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthiourea moiety I [R1 = H, Me, Ph, Bn, 4-MeOC6H4; R2 = Me, i-Pr, cyclohexyl, Ph] were synthesized, characterized and screened for their antioxidant activity, using six antioxidant anal. assays comparatively to reference compounds, ascorbic acid and quercetin. The results indicated that several compounds I demonstrated strong antioxidant activity in DPPH, ABTS, H2O2 and lipid peroxidation assays where some of them were either as active as or more active than reference compounds However, all compounds I were largely less active than references compounds in the reducing power assay. The thiourea moiety probably played a crucial role in antioxidant activity of target compounds I, as a thiolate ion. The most favorable R1 groups were hydrogen and Me, followed by Ph and benzyl, whereas most favorable R2 group was iPr, followed by Ph and Me. The combination of benzothiadiazine ring with sulfonylthiourea moieties led to valuable new antioxidants, which could be used in treatment or prevention of certain diseases or in field of cosmetics, which needed further investigations in future. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics