Bellmann-Sickert, Kathrin published the artcilePalmitoylated SDF1α Shows Increased Resistance against Proteolytic Degradation in Liver Homogenates, SDS of cas: 19788-49-9, the publication is ChemMedChem (2011), 6(1), 193-200, database is CAplus and MEDLINE.
The chemokine stromal cell-derived factor-1 α (SDF1 α) is strongly involved in organogenesis, as well as inflammation and tissue repair, and acts by attracting different kinds of stem and progenitor cells. Therefore, it constitutes an interesting compound for drug development in regenerative medicine. However, it is prone to inactivation by proteolytic cleavage in human serum. Accordingly, it has to be stabilized against enzymic degradation for any therapeutic application. We synthesized a palmitoylated SDF1α analog by native chem. ligation. Both the N-terminal thioester and the C-terminal palmitoylated fragment were prepared by solid-phase peptide synthesis. The activity of the refolded and pure compound was determined by an inositol phosphate turnover assay and revealed no loss in receptor activation. Addnl., resistance to proteolytic degradation was investigated in porcine liver homogenates and showed a near sevenfold increased half time. This study is a proof of principle approach for the lipidation of SDF1α and provides a basis for further engineering of the chemokine in order to increase its therapeutic value.
ChemMedChem published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, SDS of cas: 19788-49-9.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics