(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate
Synthesis and preliminary evaluation of a 99mTc labelled deoxyglucose complex {[99mTc]DTPA-bis(DG)} as a potential SPECT based probe for tumor imaging was written by Singh, Shivani;Singh, Sweta;Sharma, Rakesh K.;Kaul, Ankur;Mathur, Rashi;Tomar, Sarika;Varshney, Raunak;Mishra, Anil K.. And the article was included in New Journal of Chemistry in 2020.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate The following contents are mentioned in the article:
Carbohydrate based radiotracers have been in routine use as a potential PET imaging agent for tumor targeting, worldwide. The aim of our study was to develop a cost effective and more accessible SPECT based tumor targeted mol. imaging probe. A 1-D-deoxyglucose conjugate was proposed and evaluated as a tumor imaging agent. DTPA-bis(DG) was synthesized by conjugating two mols. of glucose employing a click chem. approach. It involved a facile methodol., characterization and subsequent radiolabelling with 99mTc with high radiochem. purity and specific activity (187 ± 17 MBq μmol-1) followed by in vitro and in vivo evaluation to prove its potency as an imaging agent. In vitro cytotoxicity studies in the A549 and HEK cell lines showed no substantial toxicity. A cell uptake study revealed that the transportation of [99mTc]DTPA-bis(DG) was GLUT1 independent. In vivo blood kinetic studies in New Zealand rabbits showed fast clearance with a Td1/2 of 28.12 ± 0.63 min and Te1/2 = 101.25 ± 0.34. A significant tumor uptake of 3.88 ± 0.05% ID per g was observed in A549 tumor bearing mice at 4 h p.i. The tumor-to-muscle and tumor-to-blood ratios at 4 h p.i. were 20.46 ± 0.07 and 3.59 ± 0.03 resp. No significant persistence in any other organs was observed The tumor (A549) grafted in athymic mice was clearly distinguishable in the gamma-scintigraphy image. The results suggested that this [99mTc]glycoconjugate would be a promising candidate for cancer targeted imaging. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics