Solubility and dissolution rate enhancement of ibuprofen by cyclodextrin based carbonate nanosponges was written by Shoaib, Qurat-ul-ain;Latif, Sumera;Ijaz, Qazi Amir;Afzal, Hafsa;Siddique, Muhammad Irfan;Hussain, Amjad;Arshad, Muhammad Sohail;Bukhari, Nadeem Irfan;Abbas, Nasir. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2021.Recommanded Product: Diphenyl carbonate The following contents are mentioned in the article:
In the present study nanotechnol. approach, i.e., a cyclodextrin (CD) based carbonate nanosponge was used to improve the solubility and dissolution of ibuprofen. Solvent and ultrasound assisted methods were used to prepare nanosponges using two CDs (β-CD and 2-hydroxypropyl-β-CD (2HP-β-CD)) and a cross-linker (CL) di-Ph carbonate (DPC) in varying molar ratios. Nanosponges were investigated for their solubilizing efficiency and phase solubility studies. Structural anal. by Fourier transform IR (FTIR) and powder X-ray diffraction (PXRD), thermo-anal. characterization by differential scanning calorimetry (DCS), morphol. by SEM (SEM). In-vitro drug release followed by in-vivo analgesic and anti-inflammatory studies were performed. 2HP-β-CD based nanosponges (molar ratio 0.01:0.04) prepared by ultrasound assisted method showed the highest solubilizing efficiency (i.e., 4.28 folds). Stability constant values showed that all complexes were stable. Inclusion complexes of drug was confirmed by PXRD and DSC. SEM images showed porous structures confirming the formation of cross-linked network. Particle size was in the range of 296.8 ± 64 to 611.7 ± 32nm. In-vitro release studies showed enhanced dissolution profile from nanosponge formulation (~94% from I11) as compared to the pure drug (~45% Ibuprofen) in 120min. Significant (p<0.05) extent of pain inhibition and anti-inflammatory activity was observed for nanosponge formulation when compared with the pure drug. CD based carbonate nanosponges with better solubility, enhanced release profile, improved analgesic and anti-inflammatory activity were successfully formulated for ibuprofen. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Recommanded Product: Diphenyl carbonate).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Diphenyl carbonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics