Construction of sterically congested oxindole derivatives via visible-light-induced radical-coupling was written by Shen, Yanling;Lei, Ning;Lu, Cong;Xi, Dailin;Geng, Xinxin;Tao, Pan;Su, Zhishan;Zheng, Ke. And the article was included in Chemical Science in 2021.HPLC of Formula: 604-69-3 The following contents are mentioned in the article:
A visible-light-induced modular methodol. for the synthesis of complex 3,3′-disubstituted oxindole derivatives, e.g. I, is reported. A library of valuable fluoroalkyl-containing highly sterically congested oxindole derivatives can be synthesized by a catalytic three-component radical coupling reaction under mild conditions (metal and photocatalyst free, >80 examples). This strategy shows high functional group tolerance and broad substrate compatibility. Substrates include a wide variety of terminal or non-terminal alkenes, conjugated dienes (e.g. prop-1-en-2-ylbenzene), and enynes RC(:CH2)CCR1 (R = Me, Ph, R1 = H, Ph, cyclopropyl, 3-chloropropyl), and a broad array of polyfluoroalkyl iodide and oxindoles II (R2 = 7-Cl, 5-Br, 4,6-F2, etc., R3 = Ph, 5-methylthiophen-2-yl, 6-methoxynaphthalen-1-yl, etc.), which enables modular modification of complex drug-like compounds in one chem. step. The success of solar-driven transformation, large-scale synthesis, and the late-stage functionalization of bioactive mols., as well as promising tumor-suppressing biol. activities, highlights the potential for practical applications of this strategy. Mechanistic investigations, including a series of control experiments, UV-vis spectroscopy and DFT calculations, suggest that the reaction underwent a sequential two-step radical-coupling process and the photosensitive perfluoroalkyl benzyl iodides are key intermediates in the transformation. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3HPLC of Formula: 604-69-3).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 604-69-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics