Brain targeting of venlafaxine HCl as a hydrophilic agent prepared through green lipid nanotechnology was written by Saeedi, Majid;Morteza-Semnani, Katayoun;Akbari, Jafar;Siahposht-Khachaki, Ali;Firouzi, Marzie;Goodarzi, Amin;Abootorabi, Shidrokh;Babaei, Amirhossein;Hassan Hashemi, Seyyed Mohammad;Nokhodchi, Ali. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Recommanded Product: 31566-31-1 The following contents are mentioned in the article:
This study aimed to improve venlafaxine HCl brain delivery using solid lipid nanoparticles (SLNs) made by an ultrasonication method. The impact of the ratio of two surfactants (Tween:Span) on nanoparticle behaviors and their efficiency was examined to achieve optimal brain delivery for venlafaxine. To study the solid-state of venlafaxine in SLNs and detect any potential interactions between the drug and other formulation excipients, PCS, TEM, ATR-FTIR, and DSC were employed. By reducing the HLB (Hydrophilic-lipophilic balance) of the binary surfactants, the particle size of SLN increased. The optimized nanoparticles showed an average particle size of 311.33 ±9.29 nm when the HLB of the ratio of the surfactants (Tween:Span) was adjusted to 8. The zeta potential of SLNs decreased from -15.90 ± 0.70 to -6.95±0.42 mV when the HLB of the system was reduced from 14 to 8. According to the results, the highest entrapment efficiency of 76.05 ±1.42% was observed for the formulation with the largest particle size and the lowest HLB value (HLB 8). DSC anal. showed that venlafaxine was in an amorphous state in SLN. The findings of the ATR-FTIR also excluded any chem. interactions between excipients and the drug. Venlafaxine-SLN had a prolonged release pattern, according to the in vitro diffusion process. Venlafaxine oral absorption from SLN was also substantially higher than venlafaxine solution after single-dose oral administration of venlafaxine preparations This research demonstrated that the venlafaxine-SLN might be employed as a potential nano-vehicle for venlafaxine brain delivery and potentially opens up new avenues for depression treatment. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: 31566-31-1).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 31566-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics