LC-MS/MS determination of 23 nonsteroidal anti-inflammatory drugs in traditional Chinese medicine preparation was written by Pan, Wei;Gu, Xinrong;Liu, Zhizhang;Hu, Xia. And the article was included in Yaowu Fenxi Zazhi in 2012.Related Products of 5003-48-5 The following contents are mentioned in the article:
A highly selective LC-MS/MS method using a tandem quadrupole mass spectrometer detector for rapidly screening, qual. identifying and accurate quantifying of 23 nonsteroidal anti-inflammatory (NSAIDs) added in the traditional Chinese medicine preparations was developed. Acetaminophen, aspirin, metamizole, antipyrine, loxoprofen, antondine, piroxicam, naproxen, sulindac, meloxicam, chlorzoxazone, fenbufen, ibuprofen, diclofenac, indometacin, benorilate, nimesulide, aceclofenac, oxaprozin, nabumetone, mefenamic acid, ketoprofen, celecoxib added in the blank ground samples were extracted with 80% methanol and were separated from a ACQUITY UPLC BEH C18 column within 12 min with a gradient of methanol-ammonium acetate, a tandem quadrupole mass spectrometer equipped with electrospray ionization source (ESI) was used in pos.-neg. ion mode, multiple reaction monitoring (MRM) was performed to quantify these compounds The 23 linear calibration curves were obtained with r2≥0.9901. The precision of the method were showed as RSD (n=6) ranged from 2.1% to 7.7%. The recoveries were tested at two concentrations (0.05, 1.0 mg·g-1) and ranged from 94.2% to 110% for the higher concentration The lowest limit of quantification (LLOQ) is defined as the lowest concentration giving the signal-to-noise ≥10:1, the data were 0.0013-0.05 μg·g-1. The results indicate that the method can be used in quantificational measure of nonsteroidal anti-inflammatory agents on traditional Chinese medicine preparations This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics