Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation was written by Mashaqbeh, Hadeia;Obaidat, Rana;Al-Shar’i, Nizar. And the article was included in Polymers (Basel, Switzerland) in 2021.Quality Control of Diphenyl carbonate The following contents are mentioned in the article:
Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s complexation stability and solubilization with β-cyclodextrin and β-cyclodextrin-based nanosponge. Nanosponges were prepared through the crosslinking of β-cyclodextrin with different molar ratios of di-Ph carbonate. Phase solubility experiments were conducted to evaluate the formed complexes and evaluate the potential of using β-cyclodextrin and nanosponge in pharmaceutical formulations. Furthermore, physicochem. characterizations of the prepared complexes included PXRD, FTIR, NMR, and DSC. In addition, in vitro release studies were performed for the prepared formulations. The formation of β-cyclodextrin complexes enhanced curcumin solubility up to 2.34-fold compared to the inherent solubility, compared to a 2.95-fold increment in curcumin solubility when loaded in β-cyclodextrin-based nanosponges. Interestingly, the stability constant for curcumin nanosponges was (4972.90 M-1), which was ten times higher than that for the β-cyclodextrin complex, where the value was 487.34 M-1. The study results indicated a decrease in the complexation efficiency and solubilization effect with the increased crosslinker amount This study’s findings showed the potential of using cyclodextrin-based nanosponge and the importance of studying the effect of crosslinking d. for the preparation of β-cyclodextrin-based nanosponges to be used for pharmaceutical formulations. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Quality Control of Diphenyl carbonate).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Diphenyl carbonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics