Wettability and availability of drugs was written by Lagas, M.. And the article was included in Pharmaceutisch Weekblad in 1982.HPLC of Formula: 5003-48-5 The following contents are mentioned in the article:
Water did not penetrate pellets prepared from powd. phenytoin [57-41-0] or hexobarbital (I) [56-29-1], whereas aqueous solutions of the surfactant, polysorbate 80 [9005-65-6], penetrated at a rate which depended on the polysorbate concentration (0.1-1.0%). If the drugs were rendered hydrophilic by prior mixing of the powder with a 3% Me cellulose [9004-67-5] solution and drying before compression, penetration of water, surfactant solutions, or gastric juice was practically instantaneous. The disintegration time of hard gelatin capsules containing I was 2 h in water, 15 min in 1% polysorbate 80, and 3 min (corresponding to the gelatin dissolution time) for hydrophilic I independent of the polysorbate concentration Similarly, the dissolution rate of the I capsules was increased by polysorbate and was greatest for hydrophilic I. In human subjects, 100% disintegration of capsules of hydrophilic benorilate [5003-48-5] occurred in the stomach within 60 min, as detected by release of a 99mTc label; disintegration of nonhydrophilic benorilate capsules was very slow. Absorption of I, phenytoin, and benorilate in humans was more rapid and resulted in higher plasma concentrations when the drugs were administered in capsules in the hydrophilic than in the nonhydrophilic forms. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5HPLC of Formula: 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics