Formulation and evaluation of nanosponge gel containing ketoconazole was written by Jadhao, Umesh T.;Sayali, Rathod P.;Gunesh, Dhembre N.;Shital, Sable D.;Sneha, Lokhande S.. And the article was included in Innovations in Pharmaceuticals and Pharmacotherapy in 2021.Related Products of 102-09-0 The following contents are mentioned in the article:
The aim of present work is to successfully formulate, evaluate and optimize nanosponges of ketoconazole drug for its efficient delivery through gel base. Nanosponge formulations were prepared using β-CD:cross-linker ratios of 1:15-1:3. The prepared nanosponges were evaluated for percentage yield, incorporation efficiency, particle size, drug polymer compatibility, SEM (SEM), and in vitro drug release. SEM studies confirmed their porous structure with number of nanochannels. The Fourier transform IR spectra showed stable character of ketoconazole in mixture of polymers. Differential Scanning Calorimetry study revealed that drug was involved in complexation with nanosponges. The average particle size of nanoparticles was found to be 78.81 ± 0.20 nm-336.02 ± 0.124 nm. The drug release from nanosponges was found to extend up to 8 h 82-92%. The nanosponges were formulated into gel using Carbopol 940 Batches G1 to G4 and were prepared by incorporating nanosponges equivalent to 6% weight/weight of ketoconazole in different polymer concentrations, resp., and evaluated for percent drug content, viscosity study, spreadability study, and in vitro diffusion studies. Drug diffusion from the nanosponge loaded gel formulations was show sustained rate. A sustained release topical drug delivery of ketoconazole developed as a nanosponge loaded gel offers solubilizing matrix for the drug, served as a local depot for sustained drug release, and provided a rate limiting matrix barrier for modulation of drug release. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Related Products of 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics