Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats was written by Mesnage, Robin;Teixeira, Maxime;Mandrioli, Daniele;Falcioni, Laura;Ibragim, Mariam;Ducarmon, Quinten Raymond;Zwittink, Romy Danielle;Amiel, Caroline;Panoff, Jean-Michel;Bourne, Emma;Savage, Emanuel;Mein, Charles A.;Belpoggi, Fiorella;Antoniou, Michael N.. And the article was included in Communications Biology in 2021.Electric Literature of C39H76NO8P The following contents are mentioned in the article:
Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathol. and serum biochem. measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foodstuffs (azoxystrobin, boscalid, chlorpyrifos, glyphosate, imidacloprid and thiabendazole) in Sprague-Dawley rats. Anal. of water and feed consumption, body weight, histopathol. and serum biochem. showed little effect. Contrastingly, serum and caecum metabolomics revealed that nicotinamide and tryptophan metabolism were affected, which suggested activation of an oxidative stress response. This was not reflected by gut microbial community composition changes evaluated by shotgun metagenomics. Transcriptomics of the liver showed that 257 genes had their expression changed. Gene functions affected included the regulation of response to steroid hormones and the activation of stress response pathways. Genome-wide DNA methylation anal. of the same liver samples showed that 4,255 CpG sites were differentially methylated. Overall, we demonstrated that in-depth mol. profiling in laboratory animals exposed to low concentrations of pesticides allows the detection of metabolic perturbations that would remain undetected by standard regulatory biochem. measures and which could thus improve the predictability of health risks from exposure to chem. pollutants. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Electric Literature of C39H76NO8P).
(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C39H76NO8P
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics