Peptide discs as precursors of biologically relevant supported lipid bilayers was written by Luchini, Alessandra;Sebastiani, Federica;Tidemand, Frederik Groenbaek;Batchu, Krishna Chaithanya;Campana, Mario;Fragneto, Giovanna;Cardenas, Marite;Arleth, Lise. And the article was included in Journal of Colloid and Interface Science in 2021.Product Details of 26662-94-2 The following contents are mentioned in the article:
Supported lipid bilayers (SLBs) are commonly used to investigate the structure and dynamics of biol. membranes. Vesicle fusion is a widely exploited method to produce SLBs. However, this process becomes less favored when the vesicles contain complex lipid mixtures, e.g. natural lipid extracts In these cases, it is often necessary to change exptl. parameters, such as temperature, to unphysiol. values to trigger the SLB formation. This may induce lipid degradation and is also not compatible with including membrane proteins or other biomols. into the bilayers. Here, we show that the peptide disks, ∼10 nm discoidal lipid bilayers stabilized in solution by a self-assembled 18A peptide belt, can be used as precursors for SLBs. The characterizations by means of neutron reflectometry and attenuated total reflectance-FTIR spectroscopy show that SLBs were successfully formed both from synthetic lipid mixtures (surface coverage 90-95%) and from natural lipid mixtures (surface coverage ∼85%). Traces of 18A peptide (below 0.02 M ratio) left at the support surface after the bilayer formation do not affect the SLB structure. Altogether, we demonstrate that peptide disk formation of SLBs is much faster than the SLB formation by vesicle fusion and without the need of altering any exptl. variable from physiol. relevant values. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Product Details of 26662-94-2).
(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 26662-94-2
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Ester – an overview | ScienceDirect Topics