Glycoconjugation of betulin derivatives using copper-catalyzed 1,3-dipolar azido-alkyne cycloaddition reaction and a preliminary assay of cytotoxicity of the obtained compounds was written by Grymel, Miroslawa;Pastuch-Gawolek, Gabriela;Lalik, Anna;Zawojak, Mateusz;Boczek, Seweryn;Krawczyk, Monika;Erfurt, Karol. And the article was included in Molecules in 2020.Recommanded Product: 604-69-3 The following contents are mentioned in the article:
Pentacyclic lupane-type triterpenoids, such as betulin and its synthetic derivatives, e.g., I display a broad spectrum of biol. activity. However, one of the major drawbacks of these compounds as potential therapeutic agents is their high hydrophobicity and low bioavailability. On the other hand, the presence of easily transformable functional groups in the parent structure makes betulin to have a high synthetic potential and the ability to form different derivatives In this context, research on the synthesis of new betulin derivatives as conjugates of naturally occurring triterpenoid with a monosaccharide via a linker containing a heteroaromatic 1,2,3-triazole ring was presented. It has been shown that copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction (CuAAC) provides an easy and effective way to synthesize new mol. hybrids based on natural products. The chem. structures of the obtained betulin glycoconjugates were confirmed by spectroscopic anal. Cytotoxicity of the obtained compounds was evaluated on a human breast adenocarcinoma cell line (MCF-7) and colorectal carcinoma cell line (HCT 116). The obtained results show that despite the fact that the obtained betulin glycoconjugates do not show interesting antitumor activity, the idea of adding a sugar unit to the betulin backbone may, after some modifications, turn out to be correct and allow for the targeted transport of betulin glycoconjugates into the tumor cells. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Recommanded Product: 604-69-3).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 604-69-3
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Ester – an overview | ScienceDirect Topics