Plasma metabolomics identifies the dysregulated metabolic profile of primary immune thrombocytopenia (ITP) based on GC-MS was written by Zhang, Ziyan;Wu, Xiaojin;Zhou, Meng;Qi, Jiaqian;Zhang, Rui;Li, Xueqian;Wang, Chang;Ruan, Changgeng;Han, Yue. And the article was included in Frontiers in Pharmacology in 2022.Category: esters-buliding-blocks The following contents are mentioned in the article:
ITP is a common autoimmune bleeding disorder with elusive pathogenesis. Author study was implemented to profile the plasma metabolic alterations of patients diagnosed with ITP, aiming at exploring the potential novel biomarkers and partial mechanism of ITP. The metabolomic anal. of plasma samples was conducted using GC-MS on 98 ITP patients and 30 healthy controls (HCs). Age and gender matched samples were selected to enter the training set or test set resp. OPLS-DA, t-test with FDR correction and ROC analyses were employed to screen out and evaluate the differential metabolites. Possible pathways were enriched based on metabolomics pathway anal. (MetPA). A total of 85 metabolites were investigated in author’s study and 17 differential metabolites with diagnostic potential were identified between ITP patients and HCs. MetPA showed that the metabolic disorders of ITP patients were mainly related to phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism and glyoxylate and dicarboxylate metabolism Addnl., author discriminated 6 differential metabolites and 5 enriched pathways in predicting the resistance to glucocorticoids in chronic ITP patients. The distinct metabolites discovered in author’s study could become novel biomarkers for the auxiliary diagnosis and prognosis prediction of ITP. Besides, the dysregulated pathways might contribute to the development of ITP. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Category: esters-buliding-blocks).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics