Phyto-emulsomes as a novel nano-carrier for morine hydrate to combat leukemia: In vitro and pharmacokinetic study was written by Kamel, Rabab;AbouSamra, Mona M.;Afifi, Sherif M.;Galal, Asmaa F.. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Computed Properties of C21H44O5 The following contents are mentioned in the article:
This study tackles the development of morin hydrate-loaded Phyto-Emulsomes (MH-EMs) using 尾-sitosterol as a 鈥瞙eart-friendly 鈥?alternative to cholesterol for curing leukemia. 尾-sitosterol was isolated from the aerial parts of C. pallescens Delile (Compositae). Phyto-Emulsomes were prepared using different ratios of glyceryl monostearate (GMS), phospholipon 80H (P80H) and ss-sitosterol (SS), then, their size, entrapment efficiency, and drug release were evaluated. Among the prepared formulas, MH-EM5 composed of GMS: P80H: SS (2:0.5:0.5) had the highest drug release efficiency (RE = 82.28 卤 1.96%) and the smallest particle size (271.7 卤 4.86 nm) with a uniform distribution. MH-EM5 was subjected to characterization including the micro-morphol. examination using TEM, thermal anal., in addition to biol. evaluation. The biostability of MH-EM5 in serum and bile salts was proved. The potential cytotoxicity of the free drug, MH-EM5 and its corresponding unmedicated formulation against normal oral epithelial cell and acute monocytic leukemia was studied. The results showed a negligible cytotoxicity in normal cells for all tested samples, while, cancer cells had a significant decrease in the cell viability in case of the selected formula (MH-EM5) compared to the corresponding unmedicated one as well as the free drug, at different concentrations up to 300 渭g/mL. Also, the oral bioavailability study proved the significant increase of all measured pharmacokinetic parameters, after a single oral administration of MH-EM5 compared to the free drug suspension. Regarding these findings, phyto-emulsomes can be considered as a safe and promising nanometric delivery system for the oral administration of morin hydrate due to the enhancement of its solubility, oral bioavailability and antitumor efficacy. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 纬-valerolactone.Computed Properties of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics