Methylene blue loaded solid lipid nanoparticles: Preparation, optimization, and in-vivo burn healing assessment was written by Farmoudeh, Ali;enayatifard, Reza;Saeedi, Majid;Talavaki, Fatemeh;Ghasemi, Maryam;Akbari, Jafar;Nokhodchi, Ali. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Product Details of 31566-31-1 The following contents are mentioned in the article:
Previous studies have shown that topical antioxidants are effective in controlling skin inflammation and accelerating tissue repair. Methylene blue with significant antioxidant effects was incorporated in solid lipid nanoparticles (MB-SLNs) and their impact on accelerating burn wound healing in a Wistar rat animal model was investigated. To this end, nanoparticles were prepared by ultra-sonication technique. The Box-Benken design (BBD) optimized the formulation variables, including lipid concentration, emulsifier/lipid, and sonication time. An in-vitro drug release test was performed using the dialysis tube technique, and the release kinetics was determined Partial-thickness burn wounds were induced in the skin of Wistar rats. Wound size reduction and histopathol. changes were assessed over 21 days. The optimum colloidal particles were spherical with an average size of 183.5 nm and entrapment efficiency of 75.24%. The difference between exptl. data and BBD prediction was less than 1%. The MB-SLNs release data followed the Korsmeyer-Peppas and Weibull models. Histol. results revealed that skin tissue recovery occurred significantly faster in the MB-SLNs treated group than simple methylene blue gel and neg. control. In conclusion, in-vivo studies proved that methylene blue nanoparticles with a high entrapment efficiency significantly accelerated the burn healing process. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Product Details of 31566-31-1).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 31566-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics