《Highly Chemo- and Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids》 was written by Liu, Xian; Wen, Jialin; Yao, Lin; Nie, Huifang; Jiang, Ru; Chen, Weiping; Zhang, Xumu. Computed Properties of C8H7FO2 And the article was included in Organic Letters in 2020. The article conveys some information:
The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodol. was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Computed Properties of C8H7FO2)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Computed Properties of C8H7FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics