In 2019,Nature Catalysis included an article by Ju, Minsoo; Huang, Minxue; Vine, Logan E.; Dehghany, Mahzad; Roberts, Jessica M.; Schomaker, Jennifer M.. Safety of tert-Butyl carbamate. The article was titled 《Tunable catalyst-controlled syntheses of β- and γ-amino alcohols enabled by silver-catalysed nitrene transfer》. The information in the text is summarized as follows:
Herein, two complementary silver catalysts was reported that were capable of selecting between β- or γ-C-H bonds that reside in similar steric/electronic environments, overriding a reaction at a weaker C-H bond in favor of a stronger one and activating primary C-H bonds. The mild conditions, low cost of silver, good yields and easy purification made this approach ideal for late-stage functionalizations to furnish valuable 1,2- and 1,3-aminoalcs. from easily prepared carbamate esters. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Safety of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of tert-Butyl carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics