The author of 《Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor》 were Zhang, Cunyu; Creech, Katrina L.; Zuercher, William J.; Willson, Timothy M.. And the article was published in Scientific Reports in 2019. Recommanded Product: Ethyl oxalyl monochloride The author mentioned the following in the article:
Development of an efficient and scalable synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a naturally-occurring aryl hydrocarbon receptor (AhR) ligand, allowed its biol. and phys. properties to be studied. FICZ was shown to be the most potent among a series of 6-substituted indolo[3,2-b]carbazoles I (R = H, CHO, CH2OH, C(O)OEt, C(O)OH) for activation of AhR in cells. Photostability studies of FICZ revealed a non-enzymic mechanism for its conversion to a biol. active quinone. These results further support the hypothesis that FICZ is a light-dependent hormone that links sun exposure to regulation of biol. pathways in peripheral tissues. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride) was used in this study.
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: Ethyl oxalyl monochloride
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