Yang, Hao; Zhu, Xiao-Qing; Wang, Wenjie; Chen, Yu; Hu, Zhu; Zhang, Yu; Hu, De-Xuan; Yu, Le-Mao; Agama, Keli; Pommier, Yves; An, Lin-Kun published an article in 2021. The article was titled 《The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors》, and you may find the article in Bioorganic Chemistry.Synthetic Route of C7H12O3 The information in the text is summarized as follows:
In this work, the development of the furoquinolinedione I [W = X = Y = Z = CH, N; R = absent, H, Me, Cl, etc.; R1 = H, Me, (Me)2N, etc.; R2 = H, Et, EtO(O)C, 2-nitrophenyl; R3 = OHC, HOH2C, morpholin-4-ylmethyl, etc.] and isoxazoloquinolinedione II [W = X = Y = Z = CH, N; R4 = ethoxycarbonyl, 2-chlorophenoxymethyl, 3,4-dimethoxyphenyl, etc.] TDP2 inhibitors, further structure-activity relationship (SAR) was studied. A series of furoquinolinedione derivatives I and isoxazoloquinolinedione derivatives II were synthesized and tested for enzyme inhibitions. Enzyme-based assays indicated that isoxazoloquinolinedione derivatives II selectively showed high TDP2 inhibitory activity at sub-micromolar range, as well as furoquinolinedione derivatives I at low micromolar range. The most potent II [W = N, X = H, Y = H, Z = H, R4 = 3,4-dimethoxyphenyl] showed TDP2 inhibitory activity with IC50 of 0.46 ± 0.15μM. This work will facilitate future efforts for the discovery of isoxazoloquinolinediones II TDP2 selective inhibitors. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics