Worayuthakarn, Rattana; Suddee, Nattanit; Nealmongkol, Prattya; Ruchirawat, Somsak; Thasana, Nopporn published an article in 2022. The article was titled 《Copper-Mediated C-O/C-N Bond Formation: A Facile Synthesis of 3-Amidocoumarin, 3-Amidoazacoumarin, and N -Aroylindole Derivatives》, and you may find the article in Synlett.Safety of tert-Butyl carbamate The information in the text is summarized as follows:
Three different heterocyclic systems such as 3-amidocoumarins, 3-amidoazacoumarins I [R1 = H, OMe; R2 = H, OMe; R1 = R2 = H, OMe; X = CH, N; Y = CH, N; Ar = Ph, furan-3-yl, thiophene-2-yl, etc.; Z = N, O] and N-benzoylindol-2-carboxamides II [R = H, 6-OMe, 5-OMe, etc.] were synthesized via of copper-mediated C-O/C-N bond formation from azlactones under various heating conditions. The stereochem. of the double bond dictated the nature of the products. Microwave irradiation played an important role in the isomerization of the trisubstituted olefin leading to the formation of 3-amidocoumarins and 3-amidoazacoumarins. Three products showed promising-to-good cytotoxic activities against a panel of cancer cell lines, including HepG2 (hepatoblastoma) and MOLT-3 (T-lymphoblast acute lymphoblastic leukemia). In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Safety of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Safety of tert-Butyl carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics