《A facile synthesis of ligands for the von Hippel-Lindau E3 ligase》 was written by Steinebach, Christian; Voell, Sabine Anna; Vu, Lan Phuong; Bricelj, Alesa; Sosic, Izidor; Schnakenburg, Gregor; Guetschow, Michael. SDS of cas: 4248-19-5 And the article was included in Synthesis in 2020. The article conveys some information:
The proteolysis-targeting chimeras (PROTACs) have become an integral part of different stages of drug discovery. This growing field, therefore, benefits from advancements in all segments of the design of these compounds Herein, an efficient and optimized synthetic protocol to various von Hippel-Lindau (VHL) ligands is presented, which enables easy access to multigram quantities of these essential PROTAC building blocks. Moreover, the elaborated synthesis represents a straightforward approach to further explore the chem. space of VHL ligands. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5SDS of cas: 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.SDS of cas: 4248-19-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics