Recommanded Product: tert-Butyl (5-aminopentyl)carbamateIn 2019 ,《Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: Fluorescent ligands as an example》 appeared in MedChemComm. The author of the article were Federico, Stephanie; Margiotta, Enrico; Paoletta, Silvia; Kachler, Sonja; Klotz, Karl-Norbert; Jacobson, Kenneth A.; Pastorin, Giorgia; Moro, Stefano; Spalluto, Giampiero. The article conveys some information:
A series of adenosine receptor antagonists bearing a reactive linker was developed. Functionalization of these derivatives is useful to easily obtain multi-target ligands, receptor probes, drug delivery systems, and diagnostic or theranostic systems. The pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines scaffold was chosen as a pharmacophore for the adenosine receptors. It was substituted at the 5-position with reactive linkers of different lengths. Then, these compounds, e.g., I, were used to synthesize probes for the adenosine receptors by functionalization with a fluorescent moiety. Both series of compounds were evaluated for their binding at the four adenosine receptor subtypes. Different affinity and selectivity profiles were observed towards hA1, hA2A and hA3 adenosine receptors. In particular, fluorescent compounds II [R = -(CH2)3-, -(CH2)5-, -(CH2)2O(CH2)2O(CH2)2-, etc.] behave as dual hA2A/hA3 ligands. Computational studies suggested different binding modes for developed compounds at the three receptors. Both mol. docking and supervised mol. dynamics (SuMD) simulations confirmed that the preferred binding mode at the single receptor was driven by the substitution present at the 5-position. The obtained results rationalized the compounds’ binding profile at the adenosine receptors and pave the way for the development of more potent conjugable and conjugated ligands targeting these membrane receptors. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Recommanded Product: tert-Butyl (5-aminopentyl)carbamate)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Recommanded Product: tert-Butyl (5-aminopentyl)carbamate
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