On September 9, 2019, Qin, Zezhao; Yu, Xiaofeng; Wu, Haiyang; Li, Jinge; Lv, Hongying; Yang, Xiaoniu published an article.SDS of cas: 517-23-7 The title of the article was Nonswellable and Tough Supramolecular Hydrogel Based on Strong Micelle Cross-Linkings. And the article contained the following:
Because of the difference in osmotic pressure, most tough hydrogels swell under physiol. conditions, which seriously weakens their mech. properties, limiting their applications in biomedicine. Herein, a novel strategy based on strong and high-d. micelle cross-linkings is proposed to prepare nonswellable and tough hydrogel. To realize a strong micelle cross-linker, the synergetic effect of hydrophobic and quadruple hydrogen-bonding interactions is employed by introducing an alkyl chain-protected ureido pyrimidinone moiety into a segmented copolymer backbone. The length of the alkyl is the key factor in determining the strength of the hydrophobic interaction, which was carefully tailored to gain micelles with high strength and suitable solubility A supramol. hydrogel was formed in situ by simply linking micelle cross-linkers with poly(ethylene glycol) chains. The strong and high-d. micelle cross-linkings restrain multiple effective chains outside the micelle from stretching during swelling, and the deformability of micelle cross-linkings disperses the local stress to maintain the network with high crosslinking d. upon loading. Therefore, the hydrogel exhibited an outstanding nonswelling behavior under physiol. conditions and excellent mech. properties with a compressive strength of 4 MPa. The rapid in situ gelation also facilitated injection and cell encapsulation. Meanwhile, it also showed good tissue adhesion, cytocompatibility, and suitable degradability. This novel and facile strategy can offer new insights into the exploitation of cross-linkings to prepare nonswellable hydrogels for biomedical applications. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).SDS of cas: 517-23-7
The Article related to hydrogel micelle crosslinking peg, Pharmaceuticals: Other and other aspects.SDS of cas: 517-23-7
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