In 2022,Grams, Estevao Silveira; Silva Ramos, Alessandro; Neves Muniz, Mauro; Rambo, Raoni S.; Alberton Perello, Marcia; Sperotto, Nathalia; Calle Gonzalez, Laura; Duarte, Lovaine Silva; Galina, Luiza; Silva Dadda, Adilio; Arrache Goncalves, Guilherme; Valim Bizarro, Cristiano; Basso, Luiz Augusto; Machado, Pablo published an article in Molecules. The title of the article was ãSynthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolinesã?SDS of cas: 4949-44-4 The author mentioned the following in the article:
A series of 27 N-(4-(benzyloxy)benzyl)-4-aminoquinolines were synthesized and evaluated for their ability to inhibit the M. tuberculosis H37Rv strain. Two of these compounds exhibited minimal inhibitory concentrations (MICs) similar to the first-line drug isoniazid. In addition, these hit compounds were selective for the bacillus with no significant change in viability of Vero and HepG2 cells. Finally, chem. stability, permeability and metabolic stability were also evaluated. The obtained data showed that the mol. hits can be optimized aiming at the development of drug candidates for tuberculosis treatment. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4SDS of cas: 4949-44-4)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.SDS of cas: 4949-44-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics