The author of ãTotal Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cellsã?were Abe, Takumi; Itoh, Tomoki; Terasaki, Masaru. And the article was published in Helvetica Chimica Acta in 2019. Computed Properties of C4H5ClO3 The author mentioned the following in the article:
A concise synthesis of pyrano[3,2-e]indole alkaloid fontanesine B (I) by a Fischer indolization is described. This key Fischer indolization starts with the pyran-ring and alkene intact, facilitating potential synthetic applications. Furthermore, fontanesine B and its isomer were evaluated for in vitro antiproliferative activity against human colorectal cancer cells. The isomer of fontanesine B (II) showed higher antiproliferative activity than the natural product, fontanesine B (2). The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Computed Properties of C4H5ClO3)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C4H5ClO3
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