On March 16, 2022, Zhang, Liang; Liu, Shuhua; Lin, Yunliang; Wang, Yuliang published an article.Formula: C6H8O3 The title of the article was Hydroxymethylation of active methenyl compounds: DMSO as methylene source and H2O as oxygen source. And the article contained the following:
A mild and efficient method for hydroxymethylation of active methenyl compounds was described. In this transformation, the widely available solvents DMSO and water served as methylene and oxygen sources, resp. Under promotion of activator and base, the reaction could be used for the construction of a series of α-hydroxymethylated carbonyl compounds R1COC(CH2OH)R2R3 [R1 = Me, Ph, Bn, 2-furyl, 2-thienyl; R2 = CN, MeCO, MeO2C, EtO2C, t-BuO2C, PhNHCO; R3 = Me, Et, Bn, etc.; R1R3 = (CH2)3, H2COCH2, (CH2)4, etc.] with all-carbon quaternary carbon center in good to excellent yield. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Formula: C6H8O3
The Article related to alpha hydroxymethylated carbonyl compound enantioselective preparation, dicarbonyl compound hydroxymethylation, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C6H8O3
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