Takeuchi, Yuta; Kawasaki, Shun; Akagawa, Kengo; Kudo, Kazuaki published an article in 2022, the title of the article was Iterative synthesis of nitrogen-containing polyketide via oxime intermediates.Recommanded Product: 3976-69-0 And the article contains the following content:
An iterative synthesis of nitrogen-containing polyketide was reported. Chain elongation of carboxylic acid via decarboxylative Claisen condensation with malonic acid half thioester was iteratively performed to construct carbon frameworks. β-Keto groups formed by the chain elongation were appropriately converted to O-Me oximes for incorporation of nitrogen atoms. Cyclization of the resulting oxime intermediates followed by reductive N-O cleavage afforded structurally diversed nitrogen-containing polyketides such as 2-pyridone, 4-aminopyrone, and 4-aminosalicylate. This method was finally applied to the synthesis of (R)-6-aminomellein, which was a nitrogen-substituted derivative of bioactive compound, (R)-6-methoxymellein. The versatility of the present method would enable the synthesis of diverse polyketides with nitrogen functional groups, which could be potentially utilized for the development of novel bioactive compounds The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Recommanded Product: 3976-69-0
The Article related to malonic thioester carboxylic acid decarboxylative claisen condensation, nitrogen polyketide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 3976-69-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics