On May 31, 2020, Shevalev, Robert M.; Zhmurov, Petr A.; Dar’in, Dmitry V.; Krasavin, Mikhail published an article.Synthetic Route of 517-23-7 The title of the article was Taking diazo transfer to water: α-diazo carbonyl compounds from in situ generated mesyl azide. And the article contained the following:
Mesyl azide generated in situ in aqueous medium converted a range of active methylene substrates RCH2R1 [R = prop-1-en-2-yl, tosyl, 3-pyridylcarbonyl, etc.; R1 = cyano, ethoxycarbonyl, methoxycarbonyl, acetyl; RR1 = -C(O)OC(CH3)2OC(O)-, -C(O)CH2C(CH3)2CH2C(O)-, -C(O)N(CH3)C(O)N(CH3)C(O)-] into the corresponding diazo compounds RC(=N2)R1 in good yields and high purity with no need for chromatog. purification The products RC(=N2)R1 [R = R1 = acetyl; R = acetyl, R1 = benzoyl] thus obtained are suitable for the subsequent RhII-catalyzed O-H insertions with no need for chromatog. in the interim. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Synthetic Route of 517-23-7
The Article related to diazo carbonyl compound preparation green chem, active methylene compound mesyl azide diazo transfer reaction, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 517-23-7
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