Phelan-Dickinson, Sarah J.; Palmer, Brian C.; Chen, Yue; DeLouise, Lisa A. published an article in 2020, the title of the article was The UVR filter octinoxate modulates aryl hydrocarbon receptor signaling in keratinocytes via inhibition of CYP1A1 and CYP1B1.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate And the article contains the following content:
UV radiation (UVR) is a consistent part of the environment that has both beneficial and harmful effects on human health. UVR filters in the form of com. sunscreens have been widely used to reduce the neg. health effects of UVR exposure. Despite their benefit, literature suggests that some filters can penetrate skin and have off-target biol. effects. We noted that many organic filters are hydrophobic and contain aromatic rings, making them potential modulators of Aryl hydrocarbon Receptor (AhR) signaling. We hypothesized that some filters may be able to act as agonists or antagonists on the AhR. Using a luciferase reporter cell line, we observed that the UVR filter octinoxate potentiated the ability of the known AhR ligand, 6-formylindolo[3,2-b]carbazole (FICZ), to activate the AhR. Cotreatments of keratinocytes with octinoxate and FICZ lead to increased levels of cytochrome P 4501A1 (CYP1A1) and P 4501B1 (CYP1B1) mRNA transcripts, in an AhR-dependent fashion. Mechanistic studies revealed that octinoxate is an inhibitor of CYP1A1 and CYP1B1, with IC50 values at approx. 1 μM and 586 nM, resp. In vivo topical application of octinoxate and FICZ also elevated CYP1A1 and CYP1B1 mRNA levels in mouse skin. Our results show that octinoxate is able to indirectly modulate AhR signaling by inhibiting CYP1A1 and CYP1B1 enzyme function, which may have important downstream consequences for the metabolism of various compounds and skin integrity. It is important to continue studying the off-target effects of octinoxate and other UVR filters, because they are used on skin on a daily basis world-wide. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate
The Article related to octinoxate aryl hydrocarbon receptor cyp1a1 cyp1b1 keratinocyte, cyp1a1, cyp1b1, aryl hydrocarbon receptor, octinoxate, sunscreens, Placeholder for records without volume info and other aspects.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics