On July 31, 2021, Meng, Qi; Yeung, Karen; Chan, King Ming published an article.Category: esters-buliding-blocks The title of the article was Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL). And the article contained the following:
Octocrylene (OC) is a broad-spectrum UV-absorbing chem. used in sunscreen and other personal care products. Its health effects are a concern because it has been detected in water, fish, humans, and food chains. In vivo and in vitro investigations were performed in zebrafish (Danio rerio) larvae and a zebrafish liver cell line (ZFL), resp., to understand the potential risks and mol. mechanisms of OC toxicity. The 96-h median lethal concentration (LC50) of OC was determined to be 251.8 μM in larvae and 5.5 μM in ZFL cells. Quant. real-time PCR (qRT-PCR) showed that OC induced the expression of genes for CYPs (CYP1A, CYP3A65), estrogen receptors (ERα, ERβ1, GPER), vitellogenin (VTG1), and sex determination (BRCA2, CYP19A, DMRT1, SOX9A), both in vitro and in vivo. A whole-transcriptome sequencing method was used to evaluate the gene expression profile of larvae exposed to OC. OC was found to mediate the biosynthesis of estrogens (such as estriol) and affect the antioxidant pathway (glutathione transferases and peroxisome). These findings clarify the toxic effects and mol. mechanisms of OC and support banning its use in cosmetics. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Category: esters-buliding-blocks
The Article related to octocrylene toxic effect zebrafish larvae liver cell line, endocrine disruption, gene transcription, rna-seq, sexual differentiation, sunscreen chemicals, Placeholder for records without volume info and other aspects.Category: esters-buliding-blocks
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