Abdi, Sayed Aliul Hasan; Ali, Amena; Sayed, Shabihul Fatma; Nagarajan, Sumathi; Abutahir; Alam, Prawez; Ali, Abuzer published an article in 2022, the title of the article was Sunscreen Ingredient Octocrylene′s Potency to Disrupt Vitamin D Synthesis.HPLC of Formula: 6197-30-4 And the article contains the following content:
Octocrylene is a widely used ingredient in sunscreen products, and it has been observed that the use of sunscreen has been increasing over the last few decades. In this paper, we investigated the way in which sunscreen′s ingredient octocrylene may disrupt normal vitamin D synthesis pathway, resulting in an imbalance in vitamin D levels in the body. The key techniques used for this insilico investigation were mol. docking, mol. dynamic (MD) simulation, and MMPBSA-based assessment. Vitamin D abnormalities have become very common in human health. Unknown exposure to chems. may be one of the important risk factors. In mol. docking anal., octocrylene exhibited a binding energy of -11.52 kcal/mol with vitamin D binding protein (1KXP) and -11.71 for the calcitriol native ligand. Octocrylene had a binding potency of -11.152 kcal/mol with the vitamin D receptor (1DB1), and calcitriol had a binding potency of -8.73 kcal/mol. In addition, octocrylene has shown binding energy of -8.96 kcal/mol with CYP2R1, and the calcitriol binding energy was -10.36 kcal/mol. Regarding stability, the root-mean-square deviation (RMSD), the root-mean-square fluctuation (RMSF), the radius of gyration, hydrogen bonding, and the solvent-accessible surface area (SASA) exhibited that octocrylene has a stable binding pattern similar to calcitriol. These findings revealed that incessant exposure to octocrylene may disrupt normal vitamin D synthesis. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).HPLC of Formula: 6197-30-4
The Article related to vitamin d synthesis octocrylene potency sunscreen ingredient, in silico study, octocrylene, sunscreen’s ingredient, vitamin d disruption, Placeholder for records without volume info and other aspects.HPLC of Formula: 6197-30-4
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